Head-to-Head Comparison of Bi- and Nonavalent Human Papillomavirus Vaccine-Induced Antibody Responses

Laila Sara Arroyo Mühr; Carina Eklund; Camilla Lagheden; Tiina Eriksson; Ville N. Pimenoff; Penelope Gray; Matti Lehtinen; Joakim Dillner

doi:10.1093/infdis/jiac190

Head-to-Head Comparison of Bi- and Nonavalent Human Papillomavirus Vaccine-Induced Antibody Responses

Laila Sara Arroyo Mühr, Carina Eklund, Camilla Lagheden, Tiina Eriksson, Ville N. Pimenoff, Penelope Gray, Matti Lehtinen, Joakim Dillner

Health Sciences

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

13 Downloads (Pure)

Abstract

For head-to-head comparison of human papillomavirus (HPV) antibody levels induced by different vaccines, 25-year-old vaccine-naive women were given either the bivalent (n = 188) or the nonavalent HPV vaccine (n = 184). Six months after vaccination antibodies against pseudovirions from 17 different HPV types (HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68/73) were measured. Antibodies against HPV16/18 were higher after bivalent HPV vaccination (mean international units [IU] 1140.1 and 170.5 for HPV16 and 18, respectively) than after nonavalent vaccination (265.1 and 22.3 IUs, respectively). The bivalent vaccine commonly induced antibodies against the nonvaccine HPV types 31/33/35/45 or 58. The nonavalent vaccine induced higher antibodies against HPV6/11/31/33/45/52/58 and 35.

Original language	English
Pages (from-to)	1195-1199
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	226
Issue number	7
DOIs	https://doi.org/10.1093/infdis/jiac190
Publication status	Published - 2022
Publication type	A1 Journal article-refereed

Keywords

antibody
bivalent
human papillomavirus
international units
nonavalent
vaccine

Publication forum classification

Publication forum level 2

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/infdis/jiac190Licence: CC BY-NC-ND

jiac190-1Final published version, 250 KBLicence: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-202211028100Licence: CC BY-NC-ND

Cite this

@article{b6ad1f0f976d47df90c9b4b043b9dc58,

title = "Head-to-Head Comparison of Bi- and Nonavalent Human Papillomavirus Vaccine-Induced Antibody Responses",

abstract = "For head-to-head comparison of human papillomavirus (HPV) antibody levels induced by different vaccines, 25-year-old vaccine-naive women were given either the bivalent (n = 188) or the nonavalent HPV vaccine (n = 184). Six months after vaccination antibodies against pseudovirions from 17 different HPV types (HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68/73) were measured. Antibodies against HPV16/18 were higher after bivalent HPV vaccination (mean international units [IU] 1140.1 and 170.5 for HPV16 and 18, respectively) than after nonavalent vaccination (265.1 and 22.3 IUs, respectively). The bivalent vaccine commonly induced antibodies against the nonvaccine HPV types 31/33/35/45 or 58. The nonavalent vaccine induced higher antibodies against HPV6/11/31/33/45/52/58 and 35.",

keywords = "antibody, bivalent, human papillomavirus, international units, nonavalent, vaccine",

author = "{Arroyo M{\"u}hr}, {Laila Sara} and Carina Eklund and Camilla Lagheden and Tiina Eriksson and Pimenoff, {Ville N.} and Penelope Gray and Matti Lehtinen and Joakim Dillner",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2022",

doi = "10.1093/infdis/jiac190",

language = "English",

volume = "226",

pages = "1195--1199",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Head-to-Head Comparison of Bi- and Nonavalent Human Papillomavirus Vaccine-Induced Antibody Responses

AU - Arroyo Mühr, Laila Sara

AU - Eklund, Carina

AU - Lagheden, Camilla

AU - Eriksson, Tiina

AU - Pimenoff, Ville N.

AU - Gray, Penelope

AU - Lehtinen, Matti

AU - Dillner, Joakim

PY - 2022

Y1 - 2022

N2 - For head-to-head comparison of human papillomavirus (HPV) antibody levels induced by different vaccines, 25-year-old vaccine-naive women were given either the bivalent (n = 188) or the nonavalent HPV vaccine (n = 184). Six months after vaccination antibodies against pseudovirions from 17 different HPV types (HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68/73) were measured. Antibodies against HPV16/18 were higher after bivalent HPV vaccination (mean international units [IU] 1140.1 and 170.5 for HPV16 and 18, respectively) than after nonavalent vaccination (265.1 and 22.3 IUs, respectively). The bivalent vaccine commonly induced antibodies against the nonvaccine HPV types 31/33/35/45 or 58. The nonavalent vaccine induced higher antibodies against HPV6/11/31/33/45/52/58 and 35.

AB - For head-to-head comparison of human papillomavirus (HPV) antibody levels induced by different vaccines, 25-year-old vaccine-naive women were given either the bivalent (n = 188) or the nonavalent HPV vaccine (n = 184). Six months after vaccination antibodies against pseudovirions from 17 different HPV types (HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68/73) were measured. Antibodies against HPV16/18 were higher after bivalent HPV vaccination (mean international units [IU] 1140.1 and 170.5 for HPV16 and 18, respectively) than after nonavalent vaccination (265.1 and 22.3 IUs, respectively). The bivalent vaccine commonly induced antibodies against the nonvaccine HPV types 31/33/35/45 or 58. The nonavalent vaccine induced higher antibodies against HPV6/11/31/33/45/52/58 and 35.

KW - antibody

KW - bivalent

KW - human papillomavirus

KW - international units

KW - nonavalent

KW - vaccine

U2 - 10.1093/infdis/jiac190

DO - 10.1093/infdis/jiac190

M3 - Article

C2 - 35535025

AN - SCOPUS:85139376145

SN - 0022-1899

VL - 226

SP - 1195

EP - 1199

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 7

ER -

Head-to-Head Comparison of Bi- and Nonavalent Human Papillomavirus Vaccine-Induced Antibody Responses

Abstract

Keywords

Publication forum classification

ASJC Scopus subject areas

UN SDGs

Access to Document

Fingerprint

Cite this