Head-to-Head Comparison of Bi- and Nonavalent Human Papillomavirus Vaccine-Induced Antibody Responses

Laila Sara Arroyo Mühr, Carina Eklund, Camilla Lagheden, Tiina Eriksson, Ville N. Pimenoff, Penelope Gray, Matti Lehtinen, Joakim Dillner

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For head-to-head comparison of human papillomavirus (HPV) antibody levels induced by different vaccines, 25-year-old vaccine-naive women were given either the bivalent (n = 188) or the nonavalent HPV vaccine (n = 184). Six months after vaccination antibodies against pseudovirions from 17 different HPV types (HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68/73) were measured. Antibodies against HPV16/18 were higher after bivalent HPV vaccination (mean international units [IU] 1140.1 and 170.5 for HPV16 and 18, respectively) than after nonavalent vaccination (265.1 and 22.3 IUs, respectively). The bivalent vaccine commonly induced antibodies against the nonvaccine HPV types 31/33/35/45 or 58. The nonavalent vaccine induced higher antibodies against HPV6/11/31/33/45/52/58 and 35.

Original languageEnglish
Pages (from-to)1195-1199
Number of pages5
Issue number7
Publication statusPublished - 2022
Publication typeA1 Journal article-refereed


  • antibody
  • bivalent
  • human papillomavirus
  • international units
  • nonavalent
  • vaccine

Publication forum classification

  • Publication forum level 2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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