Healthcare-associated blood stream infections in hematological patients in Finland during the years 2006-2016

Emilia Åttman, Jaana Syrjänen, Outi Lyytikäinen, Jukka Ollgren, Marjatta Sinisalo, Risto Vuento, Erja Mattila, Reetta Huttunen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Objectives: The aim was to identify the clinical characteristics, outcome, and antimicrobial susceptibility of healthcare-associated bloodstream infections (BSIs) in hematological patients. Methods: This retrospectively collected laboratory-based surveillance data include 3404 healthcare-associated BSIs in 2296 patients with a hematological malignancy in hospitals participating in the Finnish Hospital Infection Program from January 1, 2006, to December 31, 2016. Results: The most common underlying diseases were acute myelogenous leukemia (35%) and non-Hodgkin lymphoma (22%). Gram-positive organisms accounted for 60%-46% and gram-negative organisms for 24%-36% of BSIs in 2006-2016. The most common causative organism was coagulase-negative staphylococci (CoNS) (n = 731). The 7- and 28-day case fatality rates were 5.2% and 11.4%, respectively, and was highest in BSIs caused by Candida species (10.8% and 30.8%). The median age of patients increased from 59 years in 2006-2008 to 62 years in 2015-2016 (P <.01). Five percent of S aureus isolates were resistant to methicillin and five percent of Pseudomonas aeruginosa isolates were multidrug-resistant. Four percent of Klebsiella and seven percent of E coli isolates were resistant to ceftazidime. Conclusions: The proportion of gram-positive bacteria decreased and gram-negative bacteria increased over time. The case fatality rate was low and the median age of patients increased during the study.

Original languageEnglish
JournalEUROPEAN JOURNAL OF HAEMATOLOGY
Volume107
Issue number3
DOIs
Publication statusPublished - 2021
Publication typeA1 Journal article-refereed

Keywords

  • bacteremia
  • healthcare-associated
  • hematological
  • incidence density
  • resistance rate

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Hematology

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