Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children

DIABIMMUNE Study Group; Linnea Reinert-Hartwall; Heli Siljander; Taina Härkönen; Tommi Vatanen; Jorma Ilonen; Onni Niemelä; Kristiina Luopajärvi; Natalya Dorshakova; Sergei Mokurov; Aleksandr Peet; Vallo Tillmann; Raivo Uibo; Mikael Knip; Outi Vaarala; Jarno Honkanen

doi:10.1111/pai.13613

Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children

DIABIMMUNE Study Group, Linnea Reinert-Hartwall, Heli Siljander, Taina Härkönen, Tommi Vatanen, Jorma Ilonen, Onni Niemelä, Kristiina Luopajärvi, Natalya Dorshakova, Sergei Mokurov, Aleksandr Peet, Vallo Tillmann, Raivo Uibo, Mikael Knip, Outi Vaarala, Jarno Honkanen

Clinical Medicine

Research output: Contribution to journal › Article › Scientific › peer-review

3 Downloads (Pure)

Abstract

BACKGROUND: Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune-mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load.

METHODS: We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the participants in the DIABIMMUNE study from Russian Karelia (n = 60), Estonia (n = 83) and Finland (n = 89), three neighboring countries with remarkable differences in the incidences of allergies, asthma and autoimmune diseases.

RESULTS: We observed an upregulation of T helper cell signature cytokines during the first 12 months of life, reflecting natural development of adaptive immune responses. During the first years of life, circulating concentrations of epidermal growth factor (EGF) were significantly higher, especially in Russian children compared with Finnish children. The children who developed IgE sensitization showed lower levels of EGF than those without such responses.

CONCLUSION: Our results suggest that low circulating EGF levels associate with the risk of allergies possibly via the effects on the epithelial integrity and mucosal homeostasis.

Original language	English
Journal	Pediatric Allergy & Immunology
Volume	33
Issue number	1
Early online date	11 Aug 2021
DOIs	https://doi.org/10.1111/pai.13613
Publication status	Published - 2022
Publication type	A1 Journal article-refereed

Publication forum classification

Publication forum level 2

Access to Document

10.1111/pai.13613Licence: CC BY-NC-ND

pai.13613
CC BY-NC-ND
Final published version, 831 KBLicence: CC BY-NC-ND

http://urn.fi/URN:NBN:fi:tuni-202108316884Licence: CC BY-NC-ND

Cite this

DIABIMMUNE Study Group, Reinert-Hartwall, L., Siljander, H., Härkönen, T., Vatanen, T., Ilonen, J., Niemelä, O., Luopajärvi, K., Dorshakova, N., Mokurov, S., Peet, A., Tillmann, V., Uibo, R., Knip, M., Vaarala, O., & Honkanen, J. (2022). Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children. Pediatric Allergy & Immunology, 33(1). https://doi.org/10.1111/pai.13613

@article{84f5a42e3f624ed685ff841ad149f60c,

title = "Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children",

abstract = "BACKGROUND: Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune-mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load.METHODS: We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the participants in the DIABIMMUNE study from Russian Karelia (n = 60), Estonia (n = 83) and Finland (n = 89), three neighboring countries with remarkable differences in the incidences of allergies, asthma and autoimmune diseases.RESULTS: We observed an upregulation of T helper cell signature cytokines during the first 12 months of life, reflecting natural development of adaptive immune responses. During the first years of life, circulating concentrations of epidermal growth factor (EGF) were significantly higher, especially in Russian children compared with Finnish children. The children who developed IgE sensitization showed lower levels of EGF than those without such responses.CONCLUSION: Our results suggest that low circulating EGF levels associate with the risk of allergies possibly via the effects on the epithelial integrity and mucosal homeostasis.",

author = "{DIABIMMUNE Study Group} and Linnea Reinert-Hartwall and Heli Siljander and Taina H{\"a}rk{\"o}nen and Tommi Vatanen and Jorma Ilonen and Onni Niemel{\"a} and Kristiina Luopaj{\"a}rvi and Natalya Dorshakova and Sergei Mokurov and Aleksandr Peet and Vallo Tillmann and Raivo Uibo and Mikael Knip and Outi Vaarala and Jarno Honkanen",

note = "{\textcopyright} 2021 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.",

year = "2022",

doi = "10.1111/pai.13613",

language = "English",

volume = "33",

number = "1",

}

DIABIMMUNE Study Group, Reinert-Hartwall, L, Siljander, H, Härkönen, T, Vatanen, T, Ilonen, J, Niemelä, O, Luopajärvi, K, Dorshakova, N, Mokurov, S, Peet, A, Tillmann, V, Uibo, R, Knip, M, Vaarala, O & Honkanen, J 2022, 'Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children', Pediatric Allergy & Immunology, vol. 33, no. 1. https://doi.org/10.1111/pai.13613

TY - JOUR

T1 - Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children

AU - DIABIMMUNE Study Group

AU - Reinert-Hartwall, Linnea

AU - Siljander, Heli

AU - Härkönen, Taina

AU - Vatanen, Tommi

AU - Ilonen, Jorma

AU - Niemelä, Onni

AU - Luopajärvi, Kristiina

AU - Dorshakova, Natalya

AU - Mokurov, Sergei

AU - Peet, Aleksandr

AU - Tillmann, Vallo

AU - Uibo, Raivo

AU - Knip, Mikael

AU - Vaarala, Outi

AU - Honkanen, Jarno

PY - 2022

Y1 - 2022

N2 - BACKGROUND: Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune-mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load.METHODS: We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the participants in the DIABIMMUNE study from Russian Karelia (n = 60), Estonia (n = 83) and Finland (n = 89), three neighboring countries with remarkable differences in the incidences of allergies, asthma and autoimmune diseases.RESULTS: We observed an upregulation of T helper cell signature cytokines during the first 12 months of life, reflecting natural development of adaptive immune responses. During the first years of life, circulating concentrations of epidermal growth factor (EGF) were significantly higher, especially in Russian children compared with Finnish children. The children who developed IgE sensitization showed lower levels of EGF than those without such responses.CONCLUSION: Our results suggest that low circulating EGF levels associate with the risk of allergies possibly via the effects on the epithelial integrity and mucosal homeostasis.

AB - BACKGROUND: Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune-mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load.METHODS: We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the participants in the DIABIMMUNE study from Russian Karelia (n = 60), Estonia (n = 83) and Finland (n = 89), three neighboring countries with remarkable differences in the incidences of allergies, asthma and autoimmune diseases.RESULTS: We observed an upregulation of T helper cell signature cytokines during the first 12 months of life, reflecting natural development of adaptive immune responses. During the first years of life, circulating concentrations of epidermal growth factor (EGF) were significantly higher, especially in Russian children compared with Finnish children. The children who developed IgE sensitization showed lower levels of EGF than those without such responses.CONCLUSION: Our results suggest that low circulating EGF levels associate with the risk of allergies possibly via the effects on the epithelial integrity and mucosal homeostasis.

U2 - 10.1111/pai.13613

DO - 10.1111/pai.13613

M3 - Article

C2 - 34379817

SN - 1399-3038

VL - 33

JO - Pediatric Allergy & Immunology

JF - Pediatric Allergy & Immunology

IS - 1

ER -

Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children

Abstract

Publication forum classification

Access to Document

Fingerprint

Cite this