HLA-G and vertical mother-to-child transmission of human papillomavirus infection

Karolina Louvanto, Michel Roger, Marie-Claude Faucher, Kari Syrjänen, Seija Grenman, Stina Syrjänen

Research output: Contribution to journalArticleScientificpeer-review

6 Citations (Scopus)


Role of host factors in transmission of human papillomavirus (HPV)-infection from mother to her offspring is not known. Our aim was to study whether human leukocyte antigen (HLA)-G allele concordance among the mother-child pairs could facilitate vertical transmission of HPV, because HLA-G may contribute to immune tolerance in pregnancy. Altogether, 310 mother-child pairs were included from the Finnish Family HPV study. Overall, nine different HLA-G alleles were identified. The HLA-G genotype concordance of G∗01:01:01/01:04:01 increased the risk of high risk (HR)-HPV genotype positivity in cord blood and infant's oral mucosa. The mother-child concordance of G∗01:01:02/01:01:02 increased the risk of oral HPV positivity with HR-HPV genotypes both in the mother and offspring; OR 2.45 (95%CI 1.24-4.85). Discordant HLA-G allele for G∗01:04:01 and for G∗01:06 was significantly associated with infant's oral low risk (LR)-HPV at birth, OR 3.07 (95%CI 1.01-9.36) and OR 5.19 (95%CI 1.22-22.03), respectively. HLA-G had no association with HPV genotype-specific concordance between the mother and child at birth nor influence on perinatal HPV status of the child. Taken together, our results show that HLA-G molecules have a role in predicting the newborn's likelihood for oral HPV infection at birth.

Original languageEnglish
Pages (from-to)471-476
Number of pages6
Issue number6
Publication statusPublished - Jun 2018
Externally publishedYes
Publication typeA1 Journal article-refereed


  • Alleles
  • Female
  • Finland
  • Genetic Predisposition to Disease
  • Genotype
  • HLA-G Antigens/genetics
  • Histocompatibility
  • Humans
  • Immune Tolerance
  • Infant
  • Infant, Newborn
  • Infant, Newborn, Diseases/immunology
  • Infectious Disease Transmission, Vertical
  • Mouth Mucosa/physiology
  • Papillomaviridae/immunology
  • Papillomavirus Infections/immunology
  • Polymorphism, Genetic
  • Pregnancy

Fingerprint Dive into the research topics of 'HLA-G and vertical mother-to-child transmission of human papillomavirus infection'. Together they form a unique fingerprint.

Cite this