Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution

L. Zeng; D. Sirbu; P. G. Waddell; N. V. Tkachenko; M. R. Probert; A. C. Benniston

doi:10.1039/d0dt02339f

Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)₂(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution

L. Zeng, D. Sirbu, P. G. Waddell, N. V. Tkachenko, M. R. Probert, A. C. Benniston

Materials Science and Environmental Engineering

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

A new class of light-activated ruthenium(ii) complex was designed as a potential blocker of biological functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)₂(1-hydroxyanthra-9,10 quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behaviour through a series of stability tests, electrochemistry, UV-Visible kinetics and femtosecond transient absorption spectroscopy experiments. Under white light in the presence of H₂O₂two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(iii) or Ru(v) species is produced. The complexRU1shows potential to consume H₂O₂from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.

Original language	English
Pages (from-to)	13243-13252
Number of pages	10
Journal	DALTON TRANSACTIONS
Volume	49
Issue number	38
DOIs	https://doi.org/10.1039/d0dt02339f
Publication status	Published - 2020
Publication type	A1 Journal article-refereed

Funding

We thank the Royal Society of Chemistry Researcher Mobility Grant for financial support. We also thank the National Mass Spectrometry Facility at Swansea University for collecting mass spectra of the compounds and Dr Helen Waller from FMS at Newcastle University for help with the CD spectra. We would also like to thank Diamond Light Source for access to beam-line I19.

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Inorganic Chemistry

Access to Document

10.1039/d0dt02339fLicence: CC BY

Hydrogen peroxide assisted photorelease 2020
CC BY
Final published version, 1.26 MBLicence: CC BY

http://urn.fi/URN:NBN:fi:tuni-202011308305Licence: CC BY

CCDC 2013315: Experimental Crystal Structure Determination
Zeng, L. (Contributor), Sirbu, D. (Contributor), Waddell, P. G. (Contributor), Tkachenko, N. V. (Creator), Probert, M. R. (Contributor) & Benniston, A. C. (Contributor), Cambridge Crystallographic Data Centre, 1 Jul 2020
DOI: 10.5517/ccdc.csd.cc25l0ng
Dataset

Cite this

@article{ecf1462e86b34025b3b70c1b810fb8b1,

title = "Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution",

abstract = "A new class of light-activated ruthenium(ii) complex was designed as a potential blocker of biological functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)2(1-hydroxyanthra-9,10 quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behaviour through a series of stability tests, electrochemistry, UV-Visible kinetics and femtosecond transient absorption spectroscopy experiments. Under white light in the presence of H2O2two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(iii) or Ru(v) species is produced. The complexRU1shows potential to consume H2O2from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.",

author = "L. Zeng and D. Sirbu and Waddell, {P. G.} and Tkachenko, {N. V.} and Probert, {M. R.} and Benniston, {A. C.}",

note = "Funding Information: We thank the Royal Society of Chemistry Researcher Mobility Grant for financial support. We also thank the National Mass Spectrometry Facility at Swansea University for collecting mass spectra of the compounds and Dr Helen Waller from FMS at Newcastle University for help with the CD spectra. We would also like to thank Diamond Light Source for access to beam-line I19. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

doi = "10.1039/d0dt02339f",

language = "English",

volume = "49",

pages = "13243--13252",

journal = "DALTON TRANSACTIONS",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

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T1 - Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2′-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution

AU - Zeng, L.

AU - Sirbu, D.

AU - Waddell, P. G.

AU - Tkachenko, N. V.

AU - Probert, M. R.

AU - Benniston, A. C.

N1 - Funding Information: We thank the Royal Society of Chemistry Researcher Mobility Grant for financial support. We also thank the National Mass Spectrometry Facility at Swansea University for collecting mass spectra of the compounds and Dr Helen Waller from FMS at Newcastle University for help with the CD spectra. We would also like to thank Diamond Light Source for access to beam-line I19. Publisher Copyright: © The Royal Society of Chemistry 2020. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - A new class of light-activated ruthenium(ii) complex was designed as a potential blocker of biological functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)2(1-hydroxyanthra-9,10 quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behaviour through a series of stability tests, electrochemistry, UV-Visible kinetics and femtosecond transient absorption spectroscopy experiments. Under white light in the presence of H2O2two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(iii) or Ru(v) species is produced. The complexRU1shows potential to consume H2O2from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.

AB - A new class of light-activated ruthenium(ii) complex was designed as a potential blocker of biological functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)2(1-hydroxyanthra-9,10 quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behaviour through a series of stability tests, electrochemistry, UV-Visible kinetics and femtosecond transient absorption spectroscopy experiments. Under white light in the presence of H2O2two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(iii) or Ru(v) species is produced. The complexRU1shows potential to consume H2O2from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.

U2 - 10.1039/d0dt02339f

DO - 10.1039/d0dt02339f

M3 - Article

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VL - 49

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