Hyperuricemia Is Not an Independent Predictor of Erectile Dysfunction

Antti T. Tuokko; Teemu Murtola; Päivi Korhonen; Antti Kaipia

doi:10.1016/j.esxm.2020.100319

Hyperuricemia Is Not an Independent Predictor of Erectile Dysfunction

Antti T. Tuokko, Teemu Murtola, Päivi Korhonen, Antti Kaipia

Research output: Contribution to journal › Article › Scientific › peer-review

9 Citations (Scopus)

5 Downloads (Pure)

Abstract

Introduction: Erectile dysfunction (ED) is strongly associated with physiological and metabolic disturbances, and hyperuricemia has been proposed to predict the onset of ED. Aim: To investigate if hyperuricemia is an independent predictor for ED when all relevant confounding factors are taken into account. Methods: This is a cross-sectional study of men aged between 45 and 70 years. The population was well characterized for established cardiovascular risk factors, metabolic syndrome, as well as kidney function, depression, and socioeconomic factors. Analysis was limited to 254 men with complete data and also serum uric acid (SUA) measurements were available. This included 150 men with and 104 without ED. The presence and severity of ED was evaluated using International Index of Erectile Function-5 questionnaire. Risk of ED by SUA level was calculated using univariate and multivariable-adjusted logistic regression. Effect modification by participant characteristics were evaluated in subgroup analyses. Main Outcome measures: The main outcome measures of this study are prevalence and severity of erectile dysfunction. Results: Patients with ED (59% of the study population) were older than men without ED (59 vs 54 years) and had lower serum testosterone (14.3, 95% CI 11.3–17.3 vs 15.1 nmol/l, 95% CI 12.1–18.8, respectively). Regarding all other variables, the groups were comparable. No significant difference was found for SUA by ED. SUA was not associated with ED risk in univariate or multivariable analysis (multivariable-adjusted OR 1.14, 95% CI 0.59–2.19, P = .7) for SUA level higher than median compared with median or lesser (OR 1.00, 95% CI 0.997–1.006, P = .7 for continuous variable). No subgroup analysis modified the association. After multivariable adjustment age, education level and depression were statistically significant predictors of ED. Conclusions: Elevated SUA was not found to be an independent risk factor for ED. Metabolic syndrome, glomerular filtration rate, or cardiovascular risk factors did not modify this result. ED cannot be predicted based on the level of SUA. A Tuokko, T Murtola, P Korhonen, et al. Hyperuricemia Is Not an Independent Predictor of Erectile Dysfunction. Sex Med 2021;XX:XXX–XXX.

Original language	English
Article number	100319
Journal	Sexual Medicine
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.esxm.2020.100319
Publication status	Published - 2021
Publication type	A1 Journal article-refereed

Funding

Funding: No funding was received for conducting this research. The Harmonica Project and collection of the original data was supported by Central Satakunta Heath Federation of Municipalities and State Provincial Office of Western Finland . The sponsors had no role in data collection, data interpretation or writing of the manuscript.

Keywords

Cross-Sectional Study
Erectile Dysfunction
Predictive Marker
Risk Factors
Serum Uric Acid

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Reproductive Medicine
Dermatology
Urology
Behavioral Neuroscience

Access to Document

10.1016/j.esxm.2020.100319Licence: CC BY

1-s2.0-S2050116120302075-mainFinal published version, 227 KBLicence: CC BY

http://urn.fi/URN:NBN:fi:tuni-202105215266Licence: CC BY

Cite this

@article{c73dea30c1b14e0ab223937ba5d0b96e,

title = "Hyperuricemia Is Not an Independent Predictor of Erectile Dysfunction",

abstract = "Introduction: Erectile dysfunction (ED) is strongly associated with physiological and metabolic disturbances, and hyperuricemia has been proposed to predict the onset of ED. Aim: To investigate if hyperuricemia is an independent predictor for ED when all relevant confounding factors are taken into account. Methods: This is a cross-sectional study of men aged between 45 and 70 years. The population was well characterized for established cardiovascular risk factors, metabolic syndrome, as well as kidney function, depression, and socioeconomic factors. Analysis was limited to 254 men with complete data and also serum uric acid (SUA) measurements were available. This included 150 men with and 104 without ED. The presence and severity of ED was evaluated using International Index of Erectile Function-5 questionnaire. Risk of ED by SUA level was calculated using univariate and multivariable-adjusted logistic regression. Effect modification by participant characteristics were evaluated in subgroup analyses. Main Outcome measures: The main outcome measures of this study are prevalence and severity of erectile dysfunction. Results: Patients with ED (59% of the study population) were older than men without ED (59 vs 54 years) and had lower serum testosterone (14.3, 95% CI 11.3–17.3 vs 15.1 nmol/l, 95% CI 12.1–18.8, respectively). Regarding all other variables, the groups were comparable. No significant difference was found for SUA by ED. SUA was not associated with ED risk in univariate or multivariable analysis (multivariable-adjusted OR 1.14, 95% CI 0.59–2.19, P = .7) for SUA level higher than median compared with median or lesser (OR 1.00, 95% CI 0.997–1.006, P = .7 for continuous variable). No subgroup analysis modified the association. After multivariable adjustment age, education level and depression were statistically significant predictors of ED. Conclusions: Elevated SUA was not found to be an independent risk factor for ED. Metabolic syndrome, glomerular filtration rate, or cardiovascular risk factors did not modify this result. ED cannot be predicted based on the level of SUA. A Tuokko, T Murtola, P Korhonen, et al. Hyperuricemia Is Not an Independent Predictor of Erectile Dysfunction. Sex Med 2021;XX:XXX–XXX.",

keywords = "Cross-Sectional Study, Erectile Dysfunction, Predictive Marker, Risk Factors, Serum Uric Acid",

author = "Tuokko, {Antti T.} and Teemu Murtola and P{\"a}ivi Korhonen and Antti Kaipia",

note = "Funding Information: Funding: No funding was received for conducting this research. The Harmonica Project and collection of the original data was supported by Central Satakunta Heath Federation of Municipalities and State Provincial Office of Western Finland . The sponsors had no role in data collection, data interpretation or writing of the manuscript. Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

doi = "10.1016/j.esxm.2020.100319",

language = "English",

volume = "9",

number = "2",

}

TY - JOUR

T1 - Hyperuricemia Is Not an Independent Predictor of Erectile Dysfunction

AU - Tuokko, Antti T.

AU - Murtola, Teemu

AU - Korhonen, Päivi

AU - Kaipia, Antti

N1 - Funding Information: Funding: No funding was received for conducting this research. The Harmonica Project and collection of the original data was supported by Central Satakunta Heath Federation of Municipalities and State Provincial Office of Western Finland . The sponsors had no role in data collection, data interpretation or writing of the manuscript. Publisher Copyright: © 2021 The Authors

PY - 2021

Y1 - 2021

N2 - Introduction: Erectile dysfunction (ED) is strongly associated with physiological and metabolic disturbances, and hyperuricemia has been proposed to predict the onset of ED. Aim: To investigate if hyperuricemia is an independent predictor for ED when all relevant confounding factors are taken into account. Methods: This is a cross-sectional study of men aged between 45 and 70 years. The population was well characterized for established cardiovascular risk factors, metabolic syndrome, as well as kidney function, depression, and socioeconomic factors. Analysis was limited to 254 men with complete data and also serum uric acid (SUA) measurements were available. This included 150 men with and 104 without ED. The presence and severity of ED was evaluated using International Index of Erectile Function-5 questionnaire. Risk of ED by SUA level was calculated using univariate and multivariable-adjusted logistic regression. Effect modification by participant characteristics were evaluated in subgroup analyses. Main Outcome measures: The main outcome measures of this study are prevalence and severity of erectile dysfunction. Results: Patients with ED (59% of the study population) were older than men without ED (59 vs 54 years) and had lower serum testosterone (14.3, 95% CI 11.3–17.3 vs 15.1 nmol/l, 95% CI 12.1–18.8, respectively). Regarding all other variables, the groups were comparable. No significant difference was found for SUA by ED. SUA was not associated with ED risk in univariate or multivariable analysis (multivariable-adjusted OR 1.14, 95% CI 0.59–2.19, P = .7) for SUA level higher than median compared with median or lesser (OR 1.00, 95% CI 0.997–1.006, P = .7 for continuous variable). No subgroup analysis modified the association. After multivariable adjustment age, education level and depression were statistically significant predictors of ED. Conclusions: Elevated SUA was not found to be an independent risk factor for ED. Metabolic syndrome, glomerular filtration rate, or cardiovascular risk factors did not modify this result. ED cannot be predicted based on the level of SUA. A Tuokko, T Murtola, P Korhonen, et al. Hyperuricemia Is Not an Independent Predictor of Erectile Dysfunction. Sex Med 2021;XX:XXX–XXX.

AB - Introduction: Erectile dysfunction (ED) is strongly associated with physiological and metabolic disturbances, and hyperuricemia has been proposed to predict the onset of ED. Aim: To investigate if hyperuricemia is an independent predictor for ED when all relevant confounding factors are taken into account. Methods: This is a cross-sectional study of men aged between 45 and 70 years. The population was well characterized for established cardiovascular risk factors, metabolic syndrome, as well as kidney function, depression, and socioeconomic factors. Analysis was limited to 254 men with complete data and also serum uric acid (SUA) measurements were available. This included 150 men with and 104 without ED. The presence and severity of ED was evaluated using International Index of Erectile Function-5 questionnaire. Risk of ED by SUA level was calculated using univariate and multivariable-adjusted logistic regression. Effect modification by participant characteristics were evaluated in subgroup analyses. Main Outcome measures: The main outcome measures of this study are prevalence and severity of erectile dysfunction. Results: Patients with ED (59% of the study population) were older than men without ED (59 vs 54 years) and had lower serum testosterone (14.3, 95% CI 11.3–17.3 vs 15.1 nmol/l, 95% CI 12.1–18.8, respectively). Regarding all other variables, the groups were comparable. No significant difference was found for SUA by ED. SUA was not associated with ED risk in univariate or multivariable analysis (multivariable-adjusted OR 1.14, 95% CI 0.59–2.19, P = .7) for SUA level higher than median compared with median or lesser (OR 1.00, 95% CI 0.997–1.006, P = .7 for continuous variable). No subgroup analysis modified the association. After multivariable adjustment age, education level and depression were statistically significant predictors of ED. Conclusions: Elevated SUA was not found to be an independent risk factor for ED. Metabolic syndrome, glomerular filtration rate, or cardiovascular risk factors did not modify this result. ED cannot be predicted based on the level of SUA. A Tuokko, T Murtola, P Korhonen, et al. Hyperuricemia Is Not an Independent Predictor of Erectile Dysfunction. Sex Med 2021;XX:XXX–XXX.

KW - Cross-Sectional Study

KW - Erectile Dysfunction

KW - Predictive Marker

KW - Risk Factors

KW - Serum Uric Acid

U2 - 10.1016/j.esxm.2020.100319

DO - 10.1016/j.esxm.2020.100319

M3 - Article

AN - SCOPUS:85101109233

SN - 2050-1161

VL - 9

JO - Sexual Medicine

JF - Sexual Medicine

IS - 2

M1 - 100319

ER -

Hyperuricemia Is Not an Independent Predictor of Erectile Dysfunction

Abstract

Funding

Keywords

Publication forum classification

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this