Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Anniina T. Virtanen, Teemu Haikarainen, Parthasarathy Sampathkumar, Maaria Palmroth, Sanna Liukkonen, Jianping Liu, Natalia Nekhotiaeva, Stevan R. Hubbard, Olli Silvennoinen

Department of Clinical Microbiology

Research output: Contribution to journal › Article › Scientific › peer-review

12 Citations (Scopus)

31 Downloads (Pure)

13 results
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Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with Reversine
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8EX1/pdb
Dataset
Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with CDK2-IV
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8EX0/pdb
Dataset
Crystal structure of JAK2 JH2-V617F in complex with HTS-A3
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8B8U/pdb
Dataset
Crystal structure of JAK2 JH2-V617F in complex with Z902-A1
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8BA2/pdb
Dataset
Crystal structure of JAK2 JH2 in complex with Bemcentinib
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Contributor), Hubbard, S. R. (Contributor) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8BA3/pdb
Dataset
Crystal structure of JAK2 JH2-V617F in complex with Bemcentinib
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8BA4/pdb
Dataset
Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with HTSA3
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Contributor), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8EX2/pdb
Dataset
Crystal structure of JAK2 JH2-V617F in complex with Cdk2 inhibitor IV
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8B8N/pdb
Dataset
Crystal structure of JAK2 JH2 in complex with Z902-A3
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8B9H/pdb
Dataset
Crystal structure of JAK2 JH2-V617F in complex with JNJ-7706621
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8B99/pdb
Dataset
Crystal structure of JAK2 JH2-V617F in complex with Reversine
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8BAK/pdb
Dataset
Crystal structure of JAK2 JH2-V617F in complex with Z902-A3
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8B9E/pdb
Dataset
Crystal structure of JAK2 JH2-V617F in complex with CB76
Virtanen, A. T. (Creator), Haikarainen, T. (Creator), Sampathkumar, P. (Creator), Palmroth, M. (Creator), Liukkonen, S. (Creator), Liu, J. (Creator), Nekhotiaeva, N. (Creator), Hubbard, S. R. (Creator) & Silvennoinen, O. (Creator), Protein Data Bank (PDB), 1 Feb 2023
DOI: 10.2210/pdb8BAB/pdb
Dataset

Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Datasets

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