Idiopathic acute pancreatitis (IAP)-a review of the literature and algorithm proposed for the diagnostic work-up of IAP

Anu Aronen; Lucía Guilabert; Amer Hadi; Vytautas Kiudelis; Afrodita Panaitescu; Barbara Wlodarczyk; Johanna Laukkarinen; Sara Regner; Enrique de-Madaria

doi:10.21037/tgh-23-125

Idiopathic acute pancreatitis (IAP)-a review of the literature and algorithm proposed for the diagnostic work-up of IAP

Anu Aronen
, Lucía Guilabert
, Amer Hadi
, Vytautas Kiudelis
, Afrodita Panaitescu
, Barbara Wlodarczyk
, Johanna Laukkarinen
, Sara Regner
, Enrique de-Madaria^*

^*Corresponding author for this work

Research output: Contribution to journal › Review Article › peer-review

9 Citations (Scopus)

15 Downloads (Pure)

Abstract

Background and Objective: This narrative review addresses idiopathic acute pancreatitis (IAP) and its epidemiology, diagnosis, clinical course and treatment during the last decade. As there is no previously validated protocol for finding the aetiology of acute pancreatitis (AP), the primary aim of this study is to find, describe and unify evidence about the diagnostic work-up of AP to diagnose the true IAP. By finding the aetiology with the highest possible yield it may be possible to reduce recurrent AP (RAP) episodes and related morbidity and thereby decrease health care costs and possibly improve patients' quality of life. Methods: This narrative review includes articles retrieved from PubMed search with publications from 2013-2023. Cross references were used when found relevant. Key Content and Findings: The rates of aetiologies of AP and the diagnostics performed behind these numbers vary widely between different studies, time periods and different geographical regions, as there is no unified algorithm in diagnostic work-up of IAP. In this study, we describe an up-to-date summary of epidemiology, diagnostic course and treatment of IAP, and propose an algorithm of IAP diagnostics in light of recent scientific studies and their outcomes and address possible treatments of IAP. Conclusions: Although aetiology is key for AP management, there is still no validated protocol for aetiological diagnosis. IAP is relevant due to its recurrence rate and possible evolution to chronic pancreatitis. We still need more studies addressing this topic and evaluating new diagnostic protocols with advanced tests and treatment strategies in true IAP.

Original language	English
Article number	71
Number of pages	18
Journal	Translational Gastroenterology and Hepatology
Volume	9
DOIs	https://doi.org/10.21037/tgh-23-125
Publication status	Published - 30 Oct 2024
Publication type	A2 Review article in a scientific journal

Funding

Peer Review File: Available at https://tgh.amegroups.com/ article/view/10.21037/tgh-23-125/prf Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tgh.amegroups. com/article/view/10.21037/tgh-23-125/coif). L.G. received a grant from the Spanish Gastroenterology Association, not related to this paper. S.R. received a Swedish Government Grant for Clinical Research (ALF), Region Sk\u00E5ne Regional Research Grants, and support from the Einar and Inga Nilsson Foundation. She has royalties/licenses with Studentlitteratur, Lund, Sweden, and has received honoraria as a speaker from Viatris. Enrique de-Madaria has received two grants from Abbott and Viatris. Janssen, Abbott, and Viatris have paid him honoraria as a speaker, and Janssen has supported his attendance at meetings and travel expenses. He has also served on an advisory board with Medpace. The

Funders
Region Skåne Regional Research Grants
Einar and Inga Nilsson Foundation

Keywords

acute pancreatitis (AP)
aetiology
Idiopathic acute pancreatitis (IAP)
management

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Hepatology
Gastroenterology

Access to Document

10.21037/tgh-23-125Licence: CC BY-NC-ND

tgh-09-71Final published version, 230 KBLicence: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-2024112110385Licence: CC BY-NC-ND

Cite this

@article{76ca126e36904bd8a96f02f7a9dc2830,

title = "Idiopathic acute pancreatitis (IAP)-a review of the literature and algorithm proposed for the diagnostic work-up of IAP",

abstract = "Background and Objective: This narrative review addresses idiopathic acute pancreatitis (IAP) and its epidemiology, diagnosis, clinical course and treatment during the last decade. As there is no previously validated protocol for finding the aetiology of acute pancreatitis (AP), the primary aim of this study is to find, describe and unify evidence about the diagnostic work-up of AP to diagnose the true IAP. By finding the aetiology with the highest possible yield it may be possible to reduce recurrent AP (RAP) episodes and related morbidity and thereby decrease health care costs and possibly improve patients' quality of life. Methods: This narrative review includes articles retrieved from PubMed search with publications from 2013-2023. Cross references were used when found relevant. Key Content and Findings: The rates of aetiologies of AP and the diagnostics performed behind these numbers vary widely between different studies, time periods and different geographical regions, as there is no unified algorithm in diagnostic work-up of IAP. In this study, we describe an up-to-date summary of epidemiology, diagnostic course and treatment of IAP, and propose an algorithm of IAP diagnostics in light of recent scientific studies and their outcomes and address possible treatments of IAP. Conclusions: Although aetiology is key for AP management, there is still no validated protocol for aetiological diagnosis. IAP is relevant due to its recurrence rate and possible evolution to chronic pancreatitis. We still need more studies addressing this topic and evaluating new diagnostic protocols with advanced tests and treatment strategies in true IAP.",

keywords = "acute pancreatitis (AP), aetiology, Idiopathic acute pancreatitis (IAP), management",

author = "Anu Aronen and Luc{\'i}a Guilabert and Amer Hadi and Vytautas Kiudelis and Afrodita Panaitescu and Barbara Wlodarczyk and Johanna Laukkarinen and Sara Regner and Enrique de-Madaria",

year = "2024",

month = oct,

day = "30",

doi = "10.21037/tgh-23-125",

language = "English",

volume = "9",

journal = "Translational Gastroenterology and Hepatology",

issn = "2415-1289",

publisher = "AME Publishing Company",

}

TY - JOUR

T1 - Idiopathic acute pancreatitis (IAP)-a review of the literature and algorithm proposed for the diagnostic work-up of IAP

AU - Aronen, Anu

AU - Guilabert, Lucía

AU - Hadi, Amer

AU - Kiudelis, Vytautas

AU - Panaitescu, Afrodita

AU - Wlodarczyk, Barbara

AU - Laukkarinen, Johanna

AU - Regner, Sara

AU - de-Madaria, Enrique

PY - 2024/10/30

Y1 - 2024/10/30

N2 - Background and Objective: This narrative review addresses idiopathic acute pancreatitis (IAP) and its epidemiology, diagnosis, clinical course and treatment during the last decade. As there is no previously validated protocol for finding the aetiology of acute pancreatitis (AP), the primary aim of this study is to find, describe and unify evidence about the diagnostic work-up of AP to diagnose the true IAP. By finding the aetiology with the highest possible yield it may be possible to reduce recurrent AP (RAP) episodes and related morbidity and thereby decrease health care costs and possibly improve patients' quality of life. Methods: This narrative review includes articles retrieved from PubMed search with publications from 2013-2023. Cross references were used when found relevant. Key Content and Findings: The rates of aetiologies of AP and the diagnostics performed behind these numbers vary widely between different studies, time periods and different geographical regions, as there is no unified algorithm in diagnostic work-up of IAP. In this study, we describe an up-to-date summary of epidemiology, diagnostic course and treatment of IAP, and propose an algorithm of IAP diagnostics in light of recent scientific studies and their outcomes and address possible treatments of IAP. Conclusions: Although aetiology is key for AP management, there is still no validated protocol for aetiological diagnosis. IAP is relevant due to its recurrence rate and possible evolution to chronic pancreatitis. We still need more studies addressing this topic and evaluating new diagnostic protocols with advanced tests and treatment strategies in true IAP.

AB - Background and Objective: This narrative review addresses idiopathic acute pancreatitis (IAP) and its epidemiology, diagnosis, clinical course and treatment during the last decade. As there is no previously validated protocol for finding the aetiology of acute pancreatitis (AP), the primary aim of this study is to find, describe and unify evidence about the diagnostic work-up of AP to diagnose the true IAP. By finding the aetiology with the highest possible yield it may be possible to reduce recurrent AP (RAP) episodes and related morbidity and thereby decrease health care costs and possibly improve patients' quality of life. Methods: This narrative review includes articles retrieved from PubMed search with publications from 2013-2023. Cross references were used when found relevant. Key Content and Findings: The rates of aetiologies of AP and the diagnostics performed behind these numbers vary widely between different studies, time periods and different geographical regions, as there is no unified algorithm in diagnostic work-up of IAP. In this study, we describe an up-to-date summary of epidemiology, diagnostic course and treatment of IAP, and propose an algorithm of IAP diagnostics in light of recent scientific studies and their outcomes and address possible treatments of IAP. Conclusions: Although aetiology is key for AP management, there is still no validated protocol for aetiological diagnosis. IAP is relevant due to its recurrence rate and possible evolution to chronic pancreatitis. We still need more studies addressing this topic and evaluating new diagnostic protocols with advanced tests and treatment strategies in true IAP.

KW - acute pancreatitis (AP)

KW - aetiology

KW - Idiopathic acute pancreatitis (IAP)

KW - management

U2 - 10.21037/tgh-23-125

DO - 10.21037/tgh-23-125

M3 - Review Article

AN - SCOPUS:85207695858

SN - 2415-1289

VL - 9

JO - Translational Gastroenterology and Hepatology

JF - Translational Gastroenterology and Hepatology

M1 - 71

ER -

Idiopathic acute pancreatitis (IAP)-a review of the literature and algorithm proposed for the diagnostic work-up of IAP

Abstract

Funding

Keywords

Publication forum classification

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this