Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering

Anne-Marie Haaparanta, Peter Uppstu, Markus Hannula, Ville Ellä, Ari Rosling, Minna Kellomäki

    Research output: Contribution to journalArticleScientificpeer-review

    26 Citations (Scopus)

    Abstract

    Abstract Bone tissue engineering requires highly porous three-dimensional (3D) scaffolds with preferable osteoconductive properties, controlled degradation, and good dimensional stability. In this study, highly porous 3D poly(d,l-lactide-co-glycolide) (PLGA) - bioactive glass (BG) composites (PLGA/BG) were manufactured by combining highly porous 3D fibrous BG mesh skeleton with porous PLGA in a freeze-drying process. The 3D structure of the scaffolds was investigated as well as in vitro hydrolytic degradation for 10 weeks. The effect of BG on the dimensional stability, scaffold composition, pore structure, and degradation behaviour of the scaffolds was evaluated. The composites showed superior pore structure as the BG fibres inhibited shrinkage of the scaffolds. The BG was also shown to buffer the acidic degradation products of PLGA. These results demonstrate the potential of these PLGA/BG composites for bone tissue engineering, but the ability of this kind of PLGA/BG composites to promote bone regeneration will be studied in forthcoming in vivo studies.

    Original languageEnglish
    Article number5584
    Pages (from-to)457-466
    Number of pages10
    JournalMaterials Science and Engineering C: Materials for Biological Applications
    Volume56
    DOIs
    Publication statusPublished - 20 Jul 2015
    Publication typeA1 Journal article-refereed

    Keywords

    • Bioactive glass
    • Bone
    • Composite
    • Freeze-drying
    • Poly(d,l-lactide-co-glycolide)
    • Tissue engineering

    Publication forum classification

    • Publication forum level 1

    ASJC Scopus subject areas

    • General Materials Science
    • Condensed Matter Physics
    • Mechanical Engineering
    • Mechanics of Materials

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