Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering

Anne-Marie Haaparanta; Peter Uppstu; Markus Hannula; Ville Ellä; Ari Rosling; Minna Kellomäki

doi:10.1016/j.msec.2015.07.013

Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering

Anne-Marie Haaparanta, Peter Uppstu, Markus Hannula, Ville Ellä, Ari Rosling, Minna Kellomäki

Research output: Contribution to journal › Article › Scientific › peer-review

16 Citations (Scopus)

Abstract

Abstract Bone tissue engineering requires highly porous three-dimensional (3D) scaffolds with preferable osteoconductive properties, controlled degradation, and good dimensional stability. In this study, highly porous 3D poly(d,l-lactide-co-glycolide) (PLGA) - bioactive glass (BG) composites (PLGA/BG) were manufactured by combining highly porous 3D fibrous BG mesh skeleton with porous PLGA in a freeze-drying process. The 3D structure of the scaffolds was investigated as well as in vitro hydrolytic degradation for 10 weeks. The effect of BG on the dimensional stability, scaffold composition, pore structure, and degradation behaviour of the scaffolds was evaluated. The composites showed superior pore structure as the BG fibres inhibited shrinkage of the scaffolds. The BG was also shown to buffer the acidic degradation products of PLGA. These results demonstrate the potential of these PLGA/BG composites for bone tissue engineering, but the ability of this kind of PLGA/BG composites to promote bone regeneration will be studied in forthcoming in vivo studies.

Original language	English
Article number	5584
Pages (from-to)	457-466
Number of pages	10
Journal	Materials Science and Engineering C: Materials for Biological Applications
Volume	56
DOIs	https://doi.org/10.1016/j.msec.2015.07.013
Publication status	Published - 20 Jul 2015
Publication type	A1 Journal article-refereed

Keywords

Bioactive glass
Bone
Composite
Freeze-drying
Poly(d,l-lactide-co-glycolide)
Tissue engineering

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanical Engineering
Mechanics of Materials

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10.1016/j.msec.2015.07.013

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title = "Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering",

abstract = "Abstract Bone tissue engineering requires highly porous three-dimensional (3D) scaffolds with preferable osteoconductive properties, controlled degradation, and good dimensional stability. In this study, highly porous 3D poly(d,l-lactide-co-glycolide) (PLGA) - bioactive glass (BG) composites (PLGA/BG) were manufactured by combining highly porous 3D fibrous BG mesh skeleton with porous PLGA in a freeze-drying process. The 3D structure of the scaffolds was investigated as well as in vitro hydrolytic degradation for 10 weeks. The effect of BG on the dimensional stability, scaffold composition, pore structure, and degradation behaviour of the scaffolds was evaluated. The composites showed superior pore structure as the BG fibres inhibited shrinkage of the scaffolds. The BG was also shown to buffer the acidic degradation products of PLGA. These results demonstrate the potential of these PLGA/BG composites for bone tissue engineering, but the ability of this kind of PLGA/BG composites to promote bone regeneration will be studied in forthcoming in vivo studies.",

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author = "Anne-Marie Haaparanta and Peter Uppstu and Markus Hannula and Ville Ell{\"a} and Ari Rosling and Minna Kellom{\"a}ki",

year = "2015",

month = jul,

day = "20",

doi = "10.1016/j.msec.2015.07.013",

language = "English",

volume = "56",

pages = "457--466",

journal = "Materials Science and Engineering C: Materials for Biological Applications",

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Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering. / Haaparanta, Anne-Marie; Uppstu, Peter; Hannula, Markus et al.
In: Materials Science and Engineering C: Materials for Biological Applications, Vol. 56, 5584, 20.07.2015, p. 457-466.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering

AU - Haaparanta, Anne-Marie

AU - Uppstu, Peter

AU - Hannula, Markus

AU - Ellä, Ville

AU - Rosling, Ari

AU - Kellomäki, Minna

PY - 2015/7/20

Y1 - 2015/7/20

N2 - Abstract Bone tissue engineering requires highly porous three-dimensional (3D) scaffolds with preferable osteoconductive properties, controlled degradation, and good dimensional stability. In this study, highly porous 3D poly(d,l-lactide-co-glycolide) (PLGA) - bioactive glass (BG) composites (PLGA/BG) were manufactured by combining highly porous 3D fibrous BG mesh skeleton with porous PLGA in a freeze-drying process. The 3D structure of the scaffolds was investigated as well as in vitro hydrolytic degradation for 10 weeks. The effect of BG on the dimensional stability, scaffold composition, pore structure, and degradation behaviour of the scaffolds was evaluated. The composites showed superior pore structure as the BG fibres inhibited shrinkage of the scaffolds. The BG was also shown to buffer the acidic degradation products of PLGA. These results demonstrate the potential of these PLGA/BG composites for bone tissue engineering, but the ability of this kind of PLGA/BG composites to promote bone regeneration will be studied in forthcoming in vivo studies.

AB - Abstract Bone tissue engineering requires highly porous three-dimensional (3D) scaffolds with preferable osteoconductive properties, controlled degradation, and good dimensional stability. In this study, highly porous 3D poly(d,l-lactide-co-glycolide) (PLGA) - bioactive glass (BG) composites (PLGA/BG) were manufactured by combining highly porous 3D fibrous BG mesh skeleton with porous PLGA in a freeze-drying process. The 3D structure of the scaffolds was investigated as well as in vitro hydrolytic degradation for 10 weeks. The effect of BG on the dimensional stability, scaffold composition, pore structure, and degradation behaviour of the scaffolds was evaluated. The composites showed superior pore structure as the BG fibres inhibited shrinkage of the scaffolds. The BG was also shown to buffer the acidic degradation products of PLGA. These results demonstrate the potential of these PLGA/BG composites for bone tissue engineering, but the ability of this kind of PLGA/BG composites to promote bone regeneration will be studied in forthcoming in vivo studies.

KW - Bioactive glass

KW - Bone

KW - Composite

KW - Freeze-drying

KW - Poly(d,l-lactide-co-glycolide)

KW - Tissue engineering

U2 - 10.1016/j.msec.2015.07.013

DO - 10.1016/j.msec.2015.07.013

M3 - Article

AN - SCOPUS:84937212744

SN - 0928-4931

VL - 56

SP - 457

EP - 466

JO - Materials Science and Engineering C: Materials for Biological Applications

JF - Materials Science and Engineering C: Materials for Biological Applications

M1 - 5584

ER -

Improved dimensional stability with bioactive glass fibre skeleton in poly(lactide-co-glycolide) porous scaffolds for tissue engineering

Abstract

Keywords

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