In Vivo Evaluation of 3D-Printed Silica-Based Bioactive Glass Scaffolds for Bone Regeneration

Dilshat U. Tulyaganov, Elisa Fiume, Avzal Akbarov, Nigora Ziyadullaeva, Saidazim Murtazaev, Abbas Rahdar, Jonathan Massera, Enrica Verné, Francesco Baino

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    Bioactive glasses are often designed as porous implantable templates in which newly-formed bone can grow in three dimensions (3D). This research work aims to investigate the bone regenerative capability of silicate bioactive glass scaffolds produced by robocasting in comparison with powder and granule-like materials (oxide system: 47.5SiO2-10Na2O-10K2O-10MgO-20CaO-2.5P2O5, mol.%). Morphological and compositional analyses performed by scanning electron microscopy (SEM), combined with energy dispersive spectroscopy (EDS) after the bioactivity studies in a simulated body fluid (SBF) confirmed the apatite-forming ability of the scaffolds, which is key to allowing bone-bonding in vivo. The scaffolds exhibited a clear osteogenic effect upon implantation in rabbit femur and underwent gradual resorption followed by ossification. Full resorption in favor of new bone growth was achieved within 6 months. Osseous defect healing was accompanied by the formation of mature bone with abundant osteocytes and bone marrow cells. These in vivo results support the scaffold’s suitability for application in bone tissue engineering and show promise for potential translation to clinical assessment.

    Original languageEnglish
    Article number74
    Number of pages14
    Issue number2
    Publication statusPublished - Jun 2022
    Publication typeA1 Journal article-refereed


    • 3D printing
    • Bioactive glass
    • Bone tissue engineering
    • In vivo
    • Osteogenesis
    • Scaffold

    Publication forum classification

    • Publication forum level 1

    ASJC Scopus subject areas

    • Biomaterials
    • Biomedical Engineering


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