TY - JOUR
T1 - Infant growth after preterm birth and neurocognitive abilities in young adulthood
AU - Sammallahti, Sara
AU - Pyhälä, Riikka
AU - Lahti, Marius
AU - Lahti, Jari
AU - Pesonen, Anu Katriina
AU - Heinonen, Kati
AU - Hovi, Petteri
AU - Eriksson, Johan G.
AU - Strang-Karlsson, Sonja
AU - Andersson, Sture
AU - Järvenpää, Anna Liisa
AU - Kajantie, Eero
AU - Räikkönen, Katri
N1 - Funding Information:
This study was part of the Helsinki Study of Very Low Birth Weight Adults, which was funded by the Suomen Akatemia , University of Helsinki , the Finnish Medical Society Duodecim , Finska Läkaresällskapet , the Foundation for Pediatric Research in Finland , the Finnish Special Governmental Subsidy for Health Sciences , the Jalmari and Rauha Ahokas Foundation , the Juho Vainio Foundation , the Emil Aaltonen Foundation , the Novo Nordisk Foundation , the Päivikki and Sakari Sohlberg Foundation , the Signe and Ane Gyllenberg Foundation , the Yrjö Jahnsson Foundation , the Orion-Pharma Foundation , the Sigrid Jusélius Foundation , the Finnish National Graduate School of Clinical Investigation , the Wilhelm and Else Stockmann Foundation , and the Pediatric Graduate School , University of Helsinki. The authors declare no conflicts of interest.
Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Objectives To examine whether faster growth from birth to term (40 postmenstrual weeks) and during the first year thereafter was associated with better neurocognitive abilities in adults born preterm with very low birth weight (VLBW; <1500 g). Study design Weight, length, and head circumference data of 103 VLBW participants of the Helsinki Study of Very Low Birth Weight Adults were collected from records. Measures at term and at 12 months of corrected age were interpolated. The participants underwent tests of general neurocognitive ability, executive functioning, attention, and visual memory at mean age of 25.0 years. Results Faster growth from birth to term was associated with better general neurocognitive abilities, executive functioning, and visual memory in young adulthood. Effect sizes in SD units ranged from 0.23-0.43 per each SD faster growth in weight, length, or head circumference (95% CI 0.003-0.64; P values <.05). After controlling for neonatal complications, faster growth in head circumference remained more clearly associated with neurocognitive abilities than weight or length did. Growth during the first year after term was not consistently associated with neurocognitive abilities. Conclusions Within a VLBW group with high variability in early growth, faster growth from birth to term is associated with better neurocognitive abilities in young adulthood. Neurocognitive outcomes were predicted, in particular, by early postnatal head growth.
AB - Objectives To examine whether faster growth from birth to term (40 postmenstrual weeks) and during the first year thereafter was associated with better neurocognitive abilities in adults born preterm with very low birth weight (VLBW; <1500 g). Study design Weight, length, and head circumference data of 103 VLBW participants of the Helsinki Study of Very Low Birth Weight Adults were collected from records. Measures at term and at 12 months of corrected age were interpolated. The participants underwent tests of general neurocognitive ability, executive functioning, attention, and visual memory at mean age of 25.0 years. Results Faster growth from birth to term was associated with better general neurocognitive abilities, executive functioning, and visual memory in young adulthood. Effect sizes in SD units ranged from 0.23-0.43 per each SD faster growth in weight, length, or head circumference (95% CI 0.003-0.64; P values <.05). After controlling for neonatal complications, faster growth in head circumference remained more clearly associated with neurocognitive abilities than weight or length did. Growth during the first year after term was not consistently associated with neurocognitive abilities. Conclusions Within a VLBW group with high variability in early growth, faster growth from birth to term is associated with better neurocognitive abilities in young adulthood. Neurocognitive outcomes were predicted, in particular, by early postnatal head growth.
U2 - 10.1016/j.jpeds.2014.08.028
DO - 10.1016/j.jpeds.2014.08.028
M3 - Article
C2 - 25262301
AN - SCOPUS:84912062035
SN - 0022-3476
VL - 165
SP - 1109-1115.e3
JO - JOURNAL OF PEDIATRICS
JF - JOURNAL OF PEDIATRICS
IS - 6
ER -