Abstract
The function of inflammasome in the cell is to sense intracellular danger signals and--perhaps as the last cry of distress of a cell invaded by a microorganism--at an emergency situation to release interleukins (IL) outside of the cell, causing an inflammatory reaction and fever and also leads to an elevation of CRP. In a hopeless situation inflammasome-regulated pyroptosis is started. Disturbed action of inflammasomes has been linked to the pathogenesis of various disorders such as gout, atherosclerosis, asbestosis and type 2 diabetes. As the pathogenetic mechanisms of such diseases become clear, improved treatments for them may also become available.
| Original language | Finnish |
|---|---|
| Pages (from-to) | 705-711 |
| Number of pages | 7 |
| Journal | Lääketieteellinen Aikakauskirja Duodecim |
| Volume | 129 |
| Issue number | 7 |
| Publication status | Published - 2013 |
| Publication type | A2 Review article in a scientific journal |
Keywords
- auto-inflammatoriset taudit
- auto-inflammatory diseases,
- inflammasome
- inflammasomi
- inflammation
- tulehdusreaktio
Publication forum classification
- Publication forum level 1
ASJC Scopus subject areas
- General Medicine
