Inner ear barriers to nanomedicine-augmented drug delivery and imaging

Jing Zou, Ilmari Pyykkö, Jari Hyttinen

    Research output: Contribution to journalArticleScientificpeer-review

    23 Citations (Scopus)

    Abstract

    Abstract There are several challenges to inner ear drug delivery and imaging due to the existence of tight biological barriers to the target structure and the dense bone surrounding it. Advances in imaging and nanomedicine may provide knowledge for overcoming the existing limitations to both the diagnosis and treatment of inner ear diseases. Novel techniques have improved the efficacy of drug delivery and targeting to the inner ear, as well as the quality and accuracy of imaging this structure. In this review, we will describe the pathways and biological barriers of the inner ear regarding drug delivery, the beneficial applications and limitations of the imaging techniques available for inner ear research, the behavior of engineered nanomaterials in inner ear applications, and future perspectives for nanomedicine-based inner ear imaging.
    Original languageEnglish
    Pages (from-to)165-177
    JournalJournal of Otology
    Volume11
    Issue number4
    Early online date25 Nov 2016
    DOIs
    Publication statusPublished - 2016
    Publication typeA1 Journal article-refereed

    Keywords

    • Inner ear
    • medicine
    • nanotechnology
    • imaging
    • targeting
    • gene delivery
    • contrast agents

    Publication forum classification

    • No publication forum level

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