TY - JOUR
T1 - INSIGHT
T2 - An integrated framework for safe and sustainable chemical and material assessment
AU - Serra, Angela
AU - Zouraris, Dimitrios
AU - Schaffert, Alexandra
AU - Torres Maia, Marcella
AU - Tsiros, Periklis
AU - Virmani, Ishita
AU - Di Lieto, Emanuele
AU - Saarimäki, Laura Aliisa
AU - Morikka, Jack
AU - Riudavets-Puig, Rafael
AU - Varsou, Dimitra Danai
AU - Papavasileiou, Konstantinos D.
AU - Kolokathis, Panagiotis D.
AU - Mintis, Dimitris G.
AU - Tzoupis, Haralampos
AU - Tsoumanis, Andreas
AU - Melagraki, Georgia
AU - Arvanitidis, Alex
AU - Doganis, Philip
AU - Minadakis, Vasileios
AU - Savvas, Giannis
AU - Perello-y-bestard, Adrien
AU - Cucurachi, Stefano
AU - Buljan, Marija
AU - Nikiforou, Fotini
AU - Karakoltzidis, Achilleas
AU - Karakitsios, Spyros
AU - Sarigiannis, Dimosthenis A.
AU - Friedrichs, Steffi
AU - Seitz, Christian
AU - Gutierrez, Tomas Navarrete
AU - Isigonis, Panagiotis
AU - Cambier, Sébastien
AU - Marvuglia, Antonino
AU - Lindner, Gottlieb Georg
AU - Sergent, Jacques Aurélien
AU - Gheorghe, L. Cristiana
AU - Bradford, Laura Jayne A.
AU - Park, Seung Geun
AU - Ha, Seung Min
AU - Gerelkhuu, Zayakhuu
AU - Yoon, Tae Hyun
AU - Petry, Romana
AU - Martinez, Diego Stéfani Teodoro
AU - Winkler, David A.
AU - Wick, Peter
AU - Exner, Thomas E.
AU - Dondero, Francesco
AU - Serchi, Tommaso
AU - Peijnenburg, Willie
AU - Sarimveis, Haralambos
AU - Paparella, Martin
AU - Lynch, Iseult
AU - Afantitis, Antreas
AU - Greco, Dario
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025
Y1 - 2025
N2 - The assessment of chemicals and materials has traditionally been fragmented, with health, environmental, social, and economic impacts evaluated independently. This disjointed approach limits the ability to capture trade-offs and synergies necessary for comprehensive decision-making under the Safe and Sustainable by Design (SSbD) framework. The EU INSIGHT project addresses this challenge by developing a novel computational framework for integrated impact assessment, based on the Impact Outcome Pathway (IOP) approach. Extending the Adverse Outcome Pathway (AOP) concept, IOPs establish mechanistic links between chemical and material properties and their environmental, health, and socio-economic consequences. The project integrates multi-source datasets (including omics, life cycle inventories, and exposure models) into a structured knowledge graph (KG), ensuring FAIR (Findable, Accessible, Interoperable, Reusable) data principles are met. INSIGHT is being developed and validated through four case studies targeting per- and polyfluoroalkyl substances (PFAS), graphene oxide (GO), bio-based synthetic amorphous silica (SAS), and antimicrobial coatings. These studies demonstrate how multi-model simulations, decision-support tools, and artificial intelligence-driven knowledge extraction can enhance the predictability and interpretability of chemical and material impacts. Additionally, INSIGHT incorporates interactive, web-based decision maps to provide stakeholders with accessible, regulatory-compliant risk and sustainability assessments. By bridging mechanistic toxicology, exposure modeling, life cycle assessment, and socio-economic analysis, INSIGHT advances a scalable, transparent, and data-driven approach to SSbD. This project aligns with the European Green Deal and global sustainability goals, promoting safer, more sustainable innovation in chemicals and materials through an integrated, mechanistic, and computationally advanced framework.
AB - The assessment of chemicals and materials has traditionally been fragmented, with health, environmental, social, and economic impacts evaluated independently. This disjointed approach limits the ability to capture trade-offs and synergies necessary for comprehensive decision-making under the Safe and Sustainable by Design (SSbD) framework. The EU INSIGHT project addresses this challenge by developing a novel computational framework for integrated impact assessment, based on the Impact Outcome Pathway (IOP) approach. Extending the Adverse Outcome Pathway (AOP) concept, IOPs establish mechanistic links between chemical and material properties and their environmental, health, and socio-economic consequences. The project integrates multi-source datasets (including omics, life cycle inventories, and exposure models) into a structured knowledge graph (KG), ensuring FAIR (Findable, Accessible, Interoperable, Reusable) data principles are met. INSIGHT is being developed and validated through four case studies targeting per- and polyfluoroalkyl substances (PFAS), graphene oxide (GO), bio-based synthetic amorphous silica (SAS), and antimicrobial coatings. These studies demonstrate how multi-model simulations, decision-support tools, and artificial intelligence-driven knowledge extraction can enhance the predictability and interpretability of chemical and material impacts. Additionally, INSIGHT incorporates interactive, web-based decision maps to provide stakeholders with accessible, regulatory-compliant risk and sustainability assessments. By bridging mechanistic toxicology, exposure modeling, life cycle assessment, and socio-economic analysis, INSIGHT advances a scalable, transparent, and data-driven approach to SSbD. This project aligns with the European Green Deal and global sustainability goals, promoting safer, more sustainable innovation in chemicals and materials through an integrated, mechanistic, and computationally advanced framework.
KW - Chemical and material risk assessment
KW - FAIR principles
KW - Impact outcome pathway (IOP)
KW - Non-animal or new approach methods (NAMs)
KW - Safe and sustainable by design (SSbD)
U2 - 10.1016/j.csbj.2025.03.042
DO - 10.1016/j.csbj.2025.03.042
M3 - Article
AN - SCOPUS:105001847005
SN - 2001-0370
VL - 29
SP - 125
EP - 137
JO - Computational and structural biotechnology journal
JF - Computational and structural biotechnology journal
ER -
