Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

Qing-Bai She; Hugo M. Horlings; Marc J. van de Vijver; Jorma Isola; Hanina Hibshoosh; Neal Rosen; Ramon Parsons; Lao H. Saal; Sofia K. Gruvberger-Saal; Matthew Maurer; Yilun Chen; Mervi Jumppanen; Tao Su; Meaghan Dendy; Ying-Ka Ingar Lau; Lorenzo Memeo

doi:10.1186/s12885-016-2609-2

Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

Qing-Bai She
, Hugo M. Horlings
, Marc J. van de Vijver
, Jorma Isola
, Hanina Hibshoosh
, Neal Rosen
, Ramon Parsons
, Lao H. Saal
, Sofia K. Gruvberger-Saal
, Matthew Maurer
, Yilun Chen
, Mervi Jumppanen
, Tao Su
, Meaghan Dendy
, Ying-Ka Ingar Lau
, Lorenzo Memeo

Research output: Contribution to journal › Article › Scientific › peer-review

26 Citations (Scopus)

Original language	English
Article number	587
Journal	BMC Cancer
Volume	16
DOIs	https://doi.org/10.1186/s12885-016-2609-2
Publication status	Published - 2016
Publication type	A1 Journal article-refereed

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Basal-like
Breast cancer
Combination therapy
EGFR
PTEN

Publication forum classification

Publication forum level 1

Access to Document

10.1186/s12885-016-2609-2

http://urn.fi/URN:NBN:fi:uta-201608082142

Cite this

She, Q.-B., Horlings, H. M., van de Vijver, M. J., Isola, J., Hibshoosh, H., Rosen, N., Parsons, R., Saal, L. H., Gruvberger-Saal, S. K., Maurer, M., Chen, Y., Jumppanen, M., Su, T., Dendy, M., Lau, Y.-K. I., & Memeo, L. (2016). Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer. BMC Cancer, 16, Article 587. https://doi.org/10.1186/s12885-016-2609-2

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title = "Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer",

keywords = "Basal-like, Breast cancer, Combination therapy, EGFR, PTEN, Basal-like, Breast cancer, Combination therapy, EGFR, PTEN",

author = "Qing-Bai She and Horlings, \{Hugo M.\} and \{van de Vijver\}, \{Marc J.\} and Jorma Isola and Hanina Hibshoosh and Neal Rosen and Ramon Parsons and Saal, \{Lao H.\} and Gruvberger-Saal, \{Sofia K.\} and Matthew Maurer and Yilun Chen and Mervi Jumppanen and Tao Su and Meaghan Dendy and Lau, \{Ying-Ka Ingar\} and Lorenzo Memeo",

year = "2016",

doi = "10.1186/s12885-016-2609-2",

language = "English",

volume = "16",

journal = "BMC Cancer",

issn = "1471-2407",

publisher = "Springer-Verlag",

}

She, Q-B, Horlings, HM, van de Vijver, MJ, Isola, J, Hibshoosh, H, Rosen, N, Parsons, R, Saal, LH, Gruvberger-Saal, SK, Maurer, M, Chen, Y, Jumppanen, M, Su, T, Dendy, M, Lau, Y-KI & Memeo, L 2016, 'Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer', BMC Cancer, vol. 16, 587. https://doi.org/10.1186/s12885-016-2609-2

TY - JOUR

T1 - Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

AU - She, Qing-Bai

AU - Horlings, Hugo M.

AU - van de Vijver, Marc J.

AU - Isola, Jorma

AU - Hibshoosh, Hanina

AU - Rosen, Neal

AU - Parsons, Ramon

AU - Saal, Lao H.

AU - Gruvberger-Saal, Sofia K.

AU - Maurer, Matthew

AU - Chen, Yilun

AU - Jumppanen, Mervi

AU - Su, Tao

AU - Dendy, Meaghan

AU - Lau, Ying-Ka Ingar

AU - Memeo, Lorenzo

PY - 2016

Y1 - 2016

KW - Basal-like

KW - Breast cancer

KW - Combination therapy

KW - EGFR

KW - PTEN

KW - Basal-like

KW - Breast cancer

KW - Combination therapy

KW - EGFR

KW - PTEN

U2 - 10.1186/s12885-016-2609-2

DO - 10.1186/s12885-016-2609-2

M3 - Article

SN - 1471-2407

VL - 16

JO - BMC Cancer

JF - BMC Cancer

M1 - 587

ER -