Interactions of magainin-2 amide with membrane lipids

K Murzyn, T Rog, M Pasenkiewicz-Gierula

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

8 Citations (Scopus)

Abstract

Magainin-2 is a natural peptide that kills bacteria at concentrations that are harmless to animal cells. Molecular modelling methods were applied to investigate basic mechanisms of magainin-2 amide (M2a) membrane selectivity. Three computer models of a lipid matrix of either animal or bacterial membrane containing M2a were constructed and simulated. Specific interactions between membrane lipids and M2a peptides, responsible for M2a selectivity are elucidated.

Original languageEnglish
Title of host publicationComputational Science - ICCS 2004, Pt 2, Proceedings
EditorsM Bubak, GD VanAlbada, PMA Sloot, JJ Dongarra
Place of PublicationBERLIN
PublisherSpringer-Verlag Berlin Heidelberg
Pages325-331
Number of pages7
ISBN (Print)3-540-22115-8
Publication statusPublished - 2004
Externally publishedYes
Publication typeA4 Article in conference proceedings
Event4th International Conference on Computational Science (ICCS 2004) - Krakow, Poland
Duration: 6 Jun 20049 Jun 2004

Publication series

NameLECTURE NOTES IN COMPUTER SCIENCE
PublisherSPRINGER-VERLAG BERLIN
Volume3037
ISSN (Print)0302-9743

Conference

Conference4th International Conference on Computational Science (ICCS 2004)
Country/TerritoryPoland
Period6/06/049/06/04

Keywords

  • MOLECULAR-DYNAMICS
  • CONSTRUCTION
  • SIMULATION
  • PEPTIDE
  • MODEL
  • PORE

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