Interleukin 17F gene variations showed no association with BCG osteitis risk after newborn vaccination

Matti Korppi; Johanna Teräsjärvi; Milla Liehu-Martiskainen; Alex-Mikael Barkoff; Eero Lauhkonen; Heini Huhtala; Laura Pöyhönen; Kirsi Nuolivirta; Qiushui He

doi:10.1111/apa.15574

Interleukin 17F gene variations showed no association with BCG osteitis risk after newborn vaccination

Matti Korppi, Johanna Teräsjärvi, Milla Liehu-Martiskainen, Alex-Mikael Barkoff, Eero Lauhkonen, Heini Huhtala, Laura Pöyhönen, Kirsi Nuolivirta, Qiushui He

Health Sciences

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

AIM: Interleukin-17 (IL-17) family cytokines promote the host defence against mycobacterial infections. We have previously shown an association between IL17A variations and Bacillus Calmette-Guérin (BCG) osteitis. This paper evaluates the association of three IL17F polymorphisms with BCG osteitis after newborn vaccination.

METHODS: IL17F rs763780, rs11465553 and rs7741835 single nucleotide polymorphisms (SNPs) were studied in 132 adults, who presented with BCG osteitis in infancy. The genotypes and minor allele frequencies (MAFs) were compared between cases and Finnish population-based controls (N = 99) from the 1000 Genomes Project, and MAFs were compared between cases and allele data of Finnish subjects from the large Genome Aggregation Database.

RESULTS: There were no significant differences between former BCG osteitis patients and population-based controls in the IL17F rs763780 (wild 84.4% vs 84.8%), rs11465553 (86.4% vs 91.9%) or rs7741835 (65.7% vs 67.7%) genotypes. Homozygous variant genotypes were only present in 1.5%, 0.8% and 3.8% of cases, respectively. Likewise, MAFs of the three IL17F SNPs did not substantially differ from those of 11 252, 11 939 and 1371 Finnish subjects, respectively, from the available Genome Aggregation Database.

CONCLUSION: IL17F rs763780, rs11465553 and rs7741835 variations showed no association with the risk of BCG osteitis after newborn vaccination.

Original language	English
Pages (from-to)	618-623
Journal	Acta Paediatrica
Volume	110
Issue number	2
Early online date	18 Sept 2020
DOIs	https://doi.org/10.1111/apa.15574
Publication status	Published - Feb 2021
Publication type	A1 Journal article-refereed

Publication forum classification

Publication forum level 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/apa.15574

Cite this

@article{90055713d4df496ba51a62c5a899f4a8,

title = "Interleukin 17F gene variations showed no association with BCG osteitis risk after newborn vaccination",

abstract = "AIM: Interleukin-17 (IL-17) family cytokines promote the host defence against mycobacterial infections. We have previously shown an association between IL17A variations and Bacillus Calmette-Gu{\'e}rin (BCG) osteitis. This paper evaluates the association of three IL17F polymorphisms with BCG osteitis after newborn vaccination.METHODS: IL17F rs763780, rs11465553 and rs7741835 single nucleotide polymorphisms (SNPs) were studied in 132 adults, who presented with BCG osteitis in infancy. The genotypes and minor allele frequencies (MAFs) were compared between cases and Finnish population-based controls (N = 99) from the 1000 Genomes Project, and MAFs were compared between cases and allele data of Finnish subjects from the large Genome Aggregation Database.RESULTS: There were no significant differences between former BCG osteitis patients and population-based controls in the IL17F rs763780 (wild 84.4% vs 84.8%), rs11465553 (86.4% vs 91.9%) or rs7741835 (65.7% vs 67.7%) genotypes. Homozygous variant genotypes were only present in 1.5%, 0.8% and 3.8% of cases, respectively. Likewise, MAFs of the three IL17F SNPs did not substantially differ from those of 11 252, 11 939 and 1371 Finnish subjects, respectively, from the available Genome Aggregation Database.CONCLUSION: IL17F rs763780, rs11465553 and rs7741835 variations showed no association with the risk of BCG osteitis after newborn vaccination.",

author = "Matti Korppi and Johanna Ter{\"a}sj{\"a}rvi and Milla Liehu-Martiskainen and Alex-Mikael Barkoff and Eero Lauhkonen and Heini Huhtala and Laura P{\"o}yh{\"o}nen and Kirsi Nuolivirta and Qiushui He",

note = "{\textcopyright}2020 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.",

year = "2021",

month = feb,

doi = "10.1111/apa.15574",

language = "English",

volume = "110",

pages = "618--623",

number = "2",

}

TY - JOUR

T1 - Interleukin 17F gene variations showed no association with BCG osteitis risk after newborn vaccination

AU - Korppi, Matti

AU - Teräsjärvi, Johanna

AU - Liehu-Martiskainen, Milla

AU - Barkoff, Alex-Mikael

AU - Lauhkonen, Eero

AU - Huhtala, Heini

AU - Pöyhönen, Laura

AU - Nuolivirta, Kirsi

AU - He, Qiushui

PY - 2021/2

Y1 - 2021/2

N2 - AIM: Interleukin-17 (IL-17) family cytokines promote the host defence against mycobacterial infections. We have previously shown an association between IL17A variations and Bacillus Calmette-Guérin (BCG) osteitis. This paper evaluates the association of three IL17F polymorphisms with BCG osteitis after newborn vaccination.METHODS: IL17F rs763780, rs11465553 and rs7741835 single nucleotide polymorphisms (SNPs) were studied in 132 adults, who presented with BCG osteitis in infancy. The genotypes and minor allele frequencies (MAFs) were compared between cases and Finnish population-based controls (N = 99) from the 1000 Genomes Project, and MAFs were compared between cases and allele data of Finnish subjects from the large Genome Aggregation Database.RESULTS: There were no significant differences between former BCG osteitis patients and population-based controls in the IL17F rs763780 (wild 84.4% vs 84.8%), rs11465553 (86.4% vs 91.9%) or rs7741835 (65.7% vs 67.7%) genotypes. Homozygous variant genotypes were only present in 1.5%, 0.8% and 3.8% of cases, respectively. Likewise, MAFs of the three IL17F SNPs did not substantially differ from those of 11 252, 11 939 and 1371 Finnish subjects, respectively, from the available Genome Aggregation Database.CONCLUSION: IL17F rs763780, rs11465553 and rs7741835 variations showed no association with the risk of BCG osteitis after newborn vaccination.

AB - AIM: Interleukin-17 (IL-17) family cytokines promote the host defence against mycobacterial infections. We have previously shown an association between IL17A variations and Bacillus Calmette-Guérin (BCG) osteitis. This paper evaluates the association of three IL17F polymorphisms with BCG osteitis after newborn vaccination.METHODS: IL17F rs763780, rs11465553 and rs7741835 single nucleotide polymorphisms (SNPs) were studied in 132 adults, who presented with BCG osteitis in infancy. The genotypes and minor allele frequencies (MAFs) were compared between cases and Finnish population-based controls (N = 99) from the 1000 Genomes Project, and MAFs were compared between cases and allele data of Finnish subjects from the large Genome Aggregation Database.RESULTS: There were no significant differences between former BCG osteitis patients and population-based controls in the IL17F rs763780 (wild 84.4% vs 84.8%), rs11465553 (86.4% vs 91.9%) or rs7741835 (65.7% vs 67.7%) genotypes. Homozygous variant genotypes were only present in 1.5%, 0.8% and 3.8% of cases, respectively. Likewise, MAFs of the three IL17F SNPs did not substantially differ from those of 11 252, 11 939 and 1371 Finnish subjects, respectively, from the available Genome Aggregation Database.CONCLUSION: IL17F rs763780, rs11465553 and rs7741835 variations showed no association with the risk of BCG osteitis after newborn vaccination.

U2 - 10.1111/apa.15574

DO - 10.1111/apa.15574

M3 - Article

C2 - 32946631

SN - 1651-2227

VL - 110

SP - 618

EP - 623

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 2

ER -

Interleukin 17F gene variations showed no association with BCG osteitis risk after newborn vaccination

Abstract

Publication forum classification

UN SDGs

Access to Document

Fingerprint

Cite this