Intraluminal deposits: A rare cause of glaucoma drainage implant total obstruction

Juha Välimäki, Praveena Nukareddy, Hannu Uusitalo, Ulla Aapola

    Research output: Contribution to journalArticleScientificpeer-review


    Purpose: To report the unforeseen complication of total obstruction of a glaucoma drainage implant (GDI) tube lumen by white deposit material and to present a preliminary report identifying the composition of this material. Methods: Two subjects with a high IOP due to total obstruction of a GDI tube were reviewed. Both patients had a long history with brinzolamide and timolol maleate eye drops. The GDI tube was swept with a 5-0 polypropylene suture stent in order to open the tube. The intraluminal solid sample was successfully collected from the implant tube in one patient. High-performance liquid chromatography-mass spectrometry (HPLC-MS) was used to determine the origin of the intraluminal sample. Results: Intraluminal deposits containing components of antiglaucoma drugs e.g., timolol and brinzolamide are a rare cause of total obstruction of GDI tubes. Conclusions: Our study describes a new cause of total obstruction GDI tubes. The long-term use of timolol maleate and brinzolamide and their presence in the intraluminal solid sample collected from the blocked GDI tube suggest that the glaucoma medication may have a role in the pathogenesis. However, the exact mechanism is unknown and requires further studies.

    Original languageEnglish
    Pages (from-to) 307–311
    Number of pages5
    Issue number1
    Early online dateMay 2022
    Publication statusPublished - 2023
    Publication typeA1 Journal article-refereed


    • brinzolamide
    • Glaucoma tube shunt
    • high-performance liquid chromatography-mass spectrometry
    • intraluminal deposit material
    • timolol maleate

    Publication forum classification

    • Publication forum level 1

    ASJC Scopus subject areas

    • Ophthalmology


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