Light-activated drug release using an automated well plate illuminator

Laura Vesala; Robert Perttilä; Elias Kokko; Lasse Orsila; Petteri Uusimaa

doi:10.1117/12.2608745

Light-activated drug release using an automated well plate illuminator

Laura Vesala, Robert Perttilä, Elias Kokko, Lasse Orsila, Petteri Uusimaa

Department of Prehospital Emergency Care, Pain Management and Anaesthesiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

Abstract

Efficient site-specific delivery of systemic therapeutic drugs is crucial especially in oncology but has proved to be challenging. Drugs can be encapsulated into liposomes that offer improved therapeutic index and distribution of the drug. The release of the drug can be efficiently achieved by integrating light-sensitive component into liposomes and applying near-infrared light in a time- and site-specific manner. Modulight has designed a cloud-connected ML8500 automated biomedical illumination system to specifically study in vitro drug release. The design is flexible, allowing up to eight Modulight semiconductor lasers of different wavelengths to be installed in one system, as well as the capability to be configured for different well plates, depending on the application requirements. The system includes an enhanced environmental control unit to ensure that the samples are investigated in physiologically relevant conditions. This enables also mimicking pathological conditions since drug release by light can have very different efficacy in these special conditions. Here we present an important case study regarding the utilization of the ML8500 system to investigate light-activated indocyanine green based liposomes which have been previously demonstrated to have great potential as advanced drug delivery systems.

Original language	English
Title of host publication	Optical Methods for Tumor Treatment and Detection
Subtitle of host publication	Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX
Editors	David H. Kessel, Tayyaba Hasan
Publisher	SPIE
Number of pages	8
ISBN (Electronic)	9781510647510
DOIs	https://doi.org/10.1117/12.2608745
Publication status	Published - 2022
Publication type	A4 Article in conference proceedings
Event	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy - Virtual, Online Duration: 20 Feb 2022 → 24 Feb 2022 Conference number: XXX

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11940
ISSN (Print)	1605-7422

Conference

Conference	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy
City	Virtual, Online
Period	20/02/22 → 24/02/22

Keywords

advanced drug delivery
indocyanine green
lasers
liposomes
ML8500

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2608745

Cite this

Vesala, L., Perttilä, R., Kokko, E., Orsila, L., & Uusimaa, P. (2022). Light-activated drug release using an automated well plate illuminator. In D. H. Kessel, & T. Hasan (Eds.), Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX [1194003] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11940). SPIE. https://doi.org/10.1117/12.2608745

Vesala, Laura ; Perttilä, Robert ; Kokko, Elias et al. / Light-activated drug release using an automated well plate illuminator. Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX. editor / David H. Kessel ; Tayyaba Hasan. SPIE, 2022. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "Light-activated drug release using an automated well plate illuminator",

abstract = "Efficient site-specific delivery of systemic therapeutic drugs is crucial especially in oncology but has proved to be challenging. Drugs can be encapsulated into liposomes that offer improved therapeutic index and distribution of the drug. The release of the drug can be efficiently achieved by integrating light-sensitive component into liposomes and applying near-infrared light in a time- and site-specific manner. Modulight has designed a cloud-connected ML8500 automated biomedical illumination system to specifically study in vitro drug release. The design is flexible, allowing up to eight Modulight semiconductor lasers of different wavelengths to be installed in one system, as well as the capability to be configured for different well plates, depending on the application requirements. The system includes an enhanced environmental control unit to ensure that the samples are investigated in physiologically relevant conditions. This enables also mimicking pathological conditions since drug release by light can have very different efficacy in these special conditions. Here we present an important case study regarding the utilization of the ML8500 system to investigate light-activated indocyanine green based liposomes which have been previously demonstrated to have great potential as advanced drug delivery systems. ",

keywords = "advanced drug delivery, indocyanine green, lasers, liposomes, ML8500",

author = "Laura Vesala and Robert Perttil{\"a} and Elias Kokko and Lasse Orsila and Petteri Uusimaa",

note = "JUFOID=65546 Publisher Copyright: Copyright {\textcopyright} 2022 SPIE.; Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy ; Conference date: 20-02-2022 Through 24-02-2022",

year = "2022",

doi = "10.1117/12.2608745",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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Vesala, L, Perttilä, R, Kokko, E, Orsila, L & Uusimaa, P 2022, Light-activated drug release using an automated well plate illuminator. in DH Kessel & T Hasan (eds), Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX., 1194003, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11940, SPIE, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy, Virtual, Online, 20/02/22. https://doi.org/10.1117/12.2608745

Light-activated drug release using an automated well plate illuminator. / Vesala, Laura; Perttilä, Robert; Kokko, Elias et al.
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX. ed. / David H. Kessel; Tayyaba Hasan. SPIE, 2022. 1194003 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11940).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

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T1 - Light-activated drug release using an automated well plate illuminator

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AU - Perttilä, Robert

AU - Kokko, Elias

AU - Orsila, Lasse

AU - Uusimaa, Petteri

N1 - Conference code: XXX

PY - 2022

Y1 - 2022

N2 - Efficient site-specific delivery of systemic therapeutic drugs is crucial especially in oncology but has proved to be challenging. Drugs can be encapsulated into liposomes that offer improved therapeutic index and distribution of the drug. The release of the drug can be efficiently achieved by integrating light-sensitive component into liposomes and applying near-infrared light in a time- and site-specific manner. Modulight has designed a cloud-connected ML8500 automated biomedical illumination system to specifically study in vitro drug release. The design is flexible, allowing up to eight Modulight semiconductor lasers of different wavelengths to be installed in one system, as well as the capability to be configured for different well plates, depending on the application requirements. The system includes an enhanced environmental control unit to ensure that the samples are investigated in physiologically relevant conditions. This enables also mimicking pathological conditions since drug release by light can have very different efficacy in these special conditions. Here we present an important case study regarding the utilization of the ML8500 system to investigate light-activated indocyanine green based liposomes which have been previously demonstrated to have great potential as advanced drug delivery systems.

AB - Efficient site-specific delivery of systemic therapeutic drugs is crucial especially in oncology but has proved to be challenging. Drugs can be encapsulated into liposomes that offer improved therapeutic index and distribution of the drug. The release of the drug can be efficiently achieved by integrating light-sensitive component into liposomes and applying near-infrared light in a time- and site-specific manner. Modulight has designed a cloud-connected ML8500 automated biomedical illumination system to specifically study in vitro drug release. The design is flexible, allowing up to eight Modulight semiconductor lasers of different wavelengths to be installed in one system, as well as the capability to be configured for different well plates, depending on the application requirements. The system includes an enhanced environmental control unit to ensure that the samples are investigated in physiologically relevant conditions. This enables also mimicking pathological conditions since drug release by light can have very different efficacy in these special conditions. Here we present an important case study regarding the utilization of the ML8500 system to investigate light-activated indocyanine green based liposomes which have been previously demonstrated to have great potential as advanced drug delivery systems.

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KW - indocyanine green

KW - lasers

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KW - ML8500

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M3 - Conference contribution

AN - SCOPUS:85128886751

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Methods for Tumor Treatment and Detection

A2 - Kessel, David H.

A2 - Hasan, Tayyaba

PB - SPIE

T2 - Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy

Y2 - 20 February 2022 through 24 February 2022

ER -

Vesala L, Perttilä R, Kokko E, Orsila L, Uusimaa P. Light-activated drug release using an automated well plate illuminator. In Kessel DH, Hasan T, editors, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX. SPIE. 2022. 1194003. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2608745

Light-activated drug release using an automated well plate illuminator

Abstract

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Conference

Keywords

Publication forum classification

ASJC Scopus subject areas

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Cite this