Longitudinal assessment of clinically isolated syndrome with diffusion tensor imaging and volumetric MRI

Marcin Kolasa, Ullamari Hakulinen, Mika Helminen, Sanna Hagman, Minna Raunio, Maija Rossi, Antti Brander, Prasun Dastidar, Irina Elovaara

    Research output: Contribution to journalArticleScientificpeer-review

    6 Citations (Scopus)

    Abstract

    The potential of diffusion tensor imaging (DTI) indices and volumes of focal lesions on conventional magnetic resonance imaging to predict conversion to multiple sclerosis (MS) was analyzed in subjects with clinically isolated syndrome (CIS) over 4 years. Twenty patients with CIS and 10 healthy controls were included in the study. The data showed an association between the volumes of T1 and fluid-attenuated inversion recovery (FLAIR) lesions and conversion to MS (T1: P= .02: FLAIR: P= .02). The worsening of DTI indices (mean diffusivity and fractional anisotropy) was primarily seen in patients progressing to MS, but clear-cut association with conversion could not be detected.

    Original languageEnglish
    Pages (from-to)207-212
    Number of pages6
    JournalClinical Imaging
    Volume39
    Issue number2
    DOIs
    Publication statusPublished - 2015
    Publication typeA1 Journal article-refereed

    Keywords

    • Clinically isolated syndrome
    • Diffusion tensor
    • Normal-appearing gray matter
    • Normal-appearing white matter
    • Volume measurements
    • clinically isolated syndrome
    • diffusion tensor
    • normal-appearing gray matter
    • normal-appearing white matter
    • volume measurements

    Publication forum classification

    • Publication forum level 1

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