Maternal energy-adjusted fatty acid intake during pregnancy and the development of cow's milk allergy in the offspring

Anni Lamminsalo, Johanna Metsälä, Hanna Mari Takkinen, Heli Tapanainen, Mari Åkerlund, Sari Niinistö, Jorma Toppari, Jorma Ilonen, Riitta Veijola, Mikael Knip, Minna Kaila, Suvi M. Virtanen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Cow's milk allergy (CMA) is one of the earliest manifestations of allergic diseases. Early dietary factors, like maternal diet during pregnancy, may play a role in the development of allergic diseases in the offspring. We aimed to investigate the association between maternal intake of fatty acids during pregnancy and the risk of CMA in the offspring. Our study was conducted in a population-based cohort, the Finnish Type 1 Diabetes Prediction and Prevention study. We collected the maternal dietary data by a validated food frequency questionnaire. We obtained the information on CMA in the study participants (n=448) from registers and from the parents. Dietary data and information on CMA were available for 4921 children. We used logistic regression in the analyses and fatty acid intakes were energy adjusted. The maternal intake of saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids (PUFA), n-3 PUFA, n-6 PUFA, trans fatty acids, ratio of n-3 PUFA to n-6 PUFA or ratio of linoleic acid to alpha-linolenic acid were not associated with the risk of CMA in the offspring when adjusted for perinatal factors, background factors, parental history of asthma or allergic rhinitis and infant animal contacts. The intake of alpha-linolenic acid was associated with a decreased risk (OR 0.72; 95%CI 0.56-0.93) of CMA in the offspring of mothers without a history of allergic rhinitis or asthma. In conclusion the maternal intake of fatty acids during pregnancy is not associated with the risk of CMA in the offspring.

Original languageEnglish
JournalBRITISH JOURNAL OF NUTRITION
Volume128
Issue number8
Early online date12 Nov 2021
DOIs
Publication statusPublished - 2022
Publication typeA1 Journal article-refereed

Keywords

  • diet
  • fatty acid
  • Milk hypersensitivity
  • pregnancy

Publication forum classification

  • Publication forum level 2

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint

Dive into the research topics of 'Maternal energy-adjusted fatty acid intake during pregnancy and the development of cow's milk allergy in the offspring'. Together they form a unique fingerprint.

Cite this