Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study

Katri Korpela, Otto Helve, Kaija-Leena Kolho, Terhi Saisto, Kirsi Skogberg, Evgenia Dikareva, Vedran Stefanovic, Anne Salonen, Sture Andersson, Willem M. de Vos

    Research output: Contribution to journalArticleScientificpeer-review

    205 Citations (Scopus)

    Abstract

    A proof-of-concept safety study shows that oral fecal transplantation can shift the microbiome composition of infants who are born via cesarean section to a profile that is more similar to those born via vaginal delivery.

    Original languageEnglish
    Pages (from-to)324-334.e5
    JournalCell
    Volume183
    Issue number2
    DOIs
    Publication statusPublished - 2020
    Publication typeA1 Journal article-refereed

    Keywords

    • cesarean section
    • clinical trial
    • colonization
    • early-life health
    • fecal microbiota transplantation
    • maternal seeding
    • microbiota development
    • newborn
    • selective outgrowth
    • vertical transmission

    Publication forum classification

    • Publication forum level 3

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