Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

E. Porcu; S. Rüeger; K. Lepik; M. Agbessi; H. Ahsan; I. Alves; A. Andiappan; W. Arindrarto; P. Awadalla; A. Battle; F. Beutner; Jan M. Bonder; D. Boomsma; M. Christiansen; A. Claringbould; P. Deelen; T. Esko; M.-J. Favé; L. Franke; T. Frayling; S.A. Gharib; G. Gibson; B.T. Heijmans; G. Hemani; R. Jansen; M. Kähönen; A. Kalnapenkis; S. Kasela; J. Kettunen; Y. Kim; P. Kovacs; K. Krohn; J. Kronberg-Guzman; V. Kukushkina; B. Lee; T. Lehtimäki; M. Loeffler; U.M. Marigorta; H. Mei; L. Milani; G.W. Montgomery; M. Müller-Nurasyid; M. Nauck

doi:10.1038/s41467-019-10936-0

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

E. Porcu, S. Rüeger, K. Lepik, M. Agbessi, H. Ahsan, I. Alves, A. Andiappan, W. Arindrarto, P. Awadalla, A. Battle, F. Beutner, Jan M. Bonder, D. Boomsma, M. Christiansen, A. Claringbould, P. Deelen, T. Esko, M.-J. Favé, L. Franke, T. FraylingS.A. Gharib, G. Gibson, B.T. Heijmans, G. Hemani, R. Jansen, M. Kähönen, A. Kalnapenkis, S. Kasela, J. Kettunen, Y. Kim, P. Kovacs, K. Krohn, J. Kronberg-Guzman, V. Kukushkina, B. Lee, T. Lehtimäki, M. Loeffler, U.M. Marigorta, H. Mei, L. Milani, G.W. Montgomery, M. Müller-Nurasyid, M. Nauck

Research output: Contribution to journal › Article › Scientific › peer-review

36 Citations (Scopus)

Original language	English
Article number	3300
Pages (from-to)	3300
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-10936-0
Publication status	Published - 2019
Publication type	A1 Journal article-refereed

Publication forum classification

Publication forum level 3

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10.1038/s41467-019-10936-0

http://urn.fi/urn:nbn:fi:tuni-201910113822

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Porcu, E., Rüeger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, J. M., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Favé, M-J., Franke, L., ... Nauck, M. (2019). Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nature Communications, 10(1), 3300. [3300]. https://doi.org/10.1038/s41467-019-10936-0

Porcu, E. ; Rüeger, S. ; Lepik, K. ; Agbessi, M. ; Ahsan, H. ; Alves, I. ; Andiappan, A. ; Arindrarto, W. ; Awadalla, P. ; Battle, A. ; Beutner, F. ; Bonder, Jan M. ; Boomsma, D. ; Christiansen, M. ; Claringbould, A. ; Deelen, P. ; Esko, T. ; Favé, M.-J. ; Franke, L. ; Frayling, T. ; Gharib, S.A. ; Gibson, G. ; Heijmans, B.T. ; Hemani, G. ; Jansen, R. ; Kähönen, M. ; Kalnapenkis, A. ; Kasela, S. ; Kettunen, J. ; Kim, Y. ; Kovacs, P. ; Krohn, K. ; Kronberg-Guzman, J. ; Kukushkina, V. ; Lee, B. ; Lehtimäki, T. ; Loeffler, M. ; Marigorta, U.M. ; Mei, H. ; Milani, L. ; Montgomery, G.W. ; Müller-Nurasyid, M. ; Nauck, M. / Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. In: Nature Communications. 2019 ; Vol. 10, No. 1. pp. 3300.

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title = "Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits",

author = "E. Porcu and S. R{\"u}eger and K. Lepik and M. Agbessi and H. Ahsan and I. Alves and A. Andiappan and W. Arindrarto and P. Awadalla and A. Battle and F. Beutner and Bonder, {Jan M.} and D. Boomsma and M. Christiansen and A. Claringbould and P. Deelen and T. Esko and M.-J. Fav{\'e} and L. Franke and T. Frayling and S.A. Gharib and G. Gibson and B.T. Heijmans and G. Hemani and R. Jansen and M. K{\"a}h{\"o}nen and A. Kalnapenkis and S. Kasela and J. Kettunen and Y. Kim and P. Kovacs and K. Krohn and J. Kronberg-Guzman and V. Kukushkina and B. Lee and T. Lehtim{\"a}ki and M. Loeffler and U.M. Marigorta and H. Mei and L. Milani and G.W. Montgomery and M. M{\"u}ller-Nurasyid and M. Nauck",

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Porcu, E, Rüeger, S, Lepik, K, Agbessi, M, Ahsan, H, Alves, I, Andiappan, A, Arindrarto, W, Awadalla, P, Battle, A, Beutner, F, Bonder, JM, Boomsma, D, Christiansen, M, Claringbould, A, Deelen, P, Esko, T, Favé, M-J, Franke, L, Frayling, T, Gharib, SA, Gibson, G, Heijmans, BT, Hemani, G, Jansen, R, Kähönen, M, Kalnapenkis, A, Kasela, S, Kettunen, J, Kim, Y, Kovacs, P, Krohn, K, Kronberg-Guzman, J, Kukushkina, V, Lee, B, Lehtimäki, T, Loeffler, M, Marigorta, UM, Mei, H, Milani, L, Montgomery, GW, Müller-Nurasyid, M & Nauck, M 2019, 'Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits', Nature Communications, vol. 10, no. 1, 3300, pp. 3300. https://doi.org/10.1038/s41467-019-10936-0

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. / Porcu, E.; Rüeger, S.; Lepik, K.; Agbessi, M.; Ahsan, H.; Alves, I.; Andiappan, A.; Arindrarto, W.; Awadalla, P.; Battle, A.; Beutner, F.; Bonder, Jan M.; Boomsma, D.; Christiansen, M.; Claringbould, A.; Deelen, P.; Esko, T.; Favé, M.-J.; Franke, L.; Frayling, T.; Gharib, S.A.; Gibson, G.; Heijmans, B.T.; Hemani, G.; Jansen, R.; Kähönen, M.; Kalnapenkis, A.; Kasela, S.; Kettunen, J.; Kim, Y.; Kovacs, P.; Krohn, K.; Kronberg-Guzman, J.; Kukushkina, V.; Lee, B.; Lehtimäki, T.; Loeffler, M.; Marigorta, U.M.; Mei, H.; Milani, L.; Montgomery, G.W.; Müller-Nurasyid, M.; Nauck, M.

In: Nature Communications, Vol. 10, No. 1, 3300, 2019, p. 3300.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

AU - Porcu, E.

AU - Rüeger, S.

AU - Lepik, K.

AU - Agbessi, M.

AU - Ahsan, H.

AU - Alves, I.

AU - Andiappan, A.

AU - Arindrarto, W.

AU - Awadalla, P.

AU - Battle, A.

AU - Beutner, F.

AU - Bonder, Jan M.

AU - Boomsma, D.

AU - Christiansen, M.

AU - Claringbould, A.

AU - Deelen, P.

AU - Esko, T.

AU - Favé, M.-J.

AU - Franke, L.

AU - Frayling, T.

AU - Gharib, S.A.

AU - Gibson, G.

AU - Heijmans, B.T.

AU - Hemani, G.

AU - Jansen, R.

AU - Kähönen, M.

AU - Kalnapenkis, A.

AU - Kasela, S.

AU - Kettunen, J.

AU - Kim, Y.

AU - Kovacs, P.

AU - Krohn, K.

AU - Kronberg-Guzman, J.

AU - Kukushkina, V.

AU - Lee, B.

AU - Lehtimäki, T.

AU - Loeffler, M.

AU - Marigorta, U.M.

AU - Mei, H.

AU - Milani, L.

AU - Montgomery, G.W.

AU - Müller-Nurasyid, M.

AU - Nauck, M.

PY - 2019

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U2 - 10.1038/s41467-019-10936-0

DO - 10.1038/s41467-019-10936-0

M3 - Article

VL - 10

SP - 3300

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 3300

ER -