Microscopic fractures shown inside tablets after impact

Craig S. Carlson; Michiel Postema; Nicole Anderton; Markus Hannula; Joona Sorjonen; Hu Xinyue; Naoyuki Otake; Nobuki Kudo; Jari Hyttinen; Jarkko Ketolainen

doi:10.35848/1347-4065/ad21be

Microscopic fractures shown inside tablets after impact

Craig S. Carlson, Michiel Postema, Nicole Anderton, Markus Hannula, Joona Sorjonen, Hu Xinyue, Naoyuki Otake, Nobuki Kudo, Jari Hyttinen, Jarkko Ketolainen

Biomedical Technology

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

In prior work, rough handling of oral tablets had been observed to drastically speed up their disintegration in water. The purpose of this study was to confirm or refute that the formation of internal microscopic fractures during rough handling is the underlying mechanism. Impacted and control tablets were subjected to micro-computed tomography and to brightness-mode ultrasound. The former revealed fracturing with a maximum crack width of 14 𝜇m. The latter revealed strong acoustic response from the internal structure of the impacted tablets. These results confirm the hypothesis. Disintegration speed is used as a quality control mechanism after tablet manufacturing and transportation.

Original language	English
Article number	028005
Journal	Japanese Journal of Applied Physics
Volume	63
Issue number	2
DOIs	https://doi.org/10.35848/1347-4065/ad21be
Publication status	Published - 6 Feb 2024
Publication type	A1 Journal article-refereed

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https://urn.fi/URN:NBN:fi:tuni-202405025176Licence: CC BY-NC-ND

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title = "Microscopic fractures shown inside tablets after impact",

abstract = "In prior work, rough handling of oral tablets had been observed to drastically speed up their disintegration in water. The purpose of this study was to confirm or refute that the formation of internal microscopic fractures during rough handling is the underlying mechanism. Impacted and control tablets were subjected to micro-computed tomography and to brightness-mode ultrasound. The former revealed fracturing with a maximum crack width of 14 𝜇m. The latter revealed strong acoustic response from the internal structure of the impacted tablets. These results confirm the hypothesis. Disintegration speed is used as a quality control mechanism after tablet manufacturing and transportation.",

author = "Carlson, {Craig S.} and Michiel Postema and Nicole Anderton and Markus Hannula and Joona Sorjonen and Hu Xinyue and Naoyuki Otake and Nobuki Kudo and Jari Hyttinen and Jarkko Ketolainen",

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T1 - Microscopic fractures shown inside tablets after impact

AU - Carlson, Craig S.

AU - Postema, Michiel

AU - Anderton, Nicole

AU - Hannula, Markus

AU - Sorjonen, Joona

AU - Xinyue, Hu

AU - Otake, Naoyuki

AU - Kudo, Nobuki

AU - Hyttinen, Jari

AU - Ketolainen, Jarkko

PY - 2024/2/6

Y1 - 2024/2/6

N2 - In prior work, rough handling of oral tablets had been observed to drastically speed up their disintegration in water. The purpose of this study was to confirm or refute that the formation of internal microscopic fractures during rough handling is the underlying mechanism. Impacted and control tablets were subjected to micro-computed tomography and to brightness-mode ultrasound. The former revealed fracturing with a maximum crack width of 14 𝜇m. The latter revealed strong acoustic response from the internal structure of the impacted tablets. These results confirm the hypothesis. Disintegration speed is used as a quality control mechanism after tablet manufacturing and transportation.

AB - In prior work, rough handling of oral tablets had been observed to drastically speed up their disintegration in water. The purpose of this study was to confirm or refute that the formation of internal microscopic fractures during rough handling is the underlying mechanism. Impacted and control tablets were subjected to micro-computed tomography and to brightness-mode ultrasound. The former revealed fracturing with a maximum crack width of 14 𝜇m. The latter revealed strong acoustic response from the internal structure of the impacted tablets. These results confirm the hypothesis. Disintegration speed is used as a quality control mechanism after tablet manufacturing and transportation.

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DO - 10.35848/1347-4065/ad21be

M3 - Article

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VL - 63

JO - Japanese Journal of Applied Physics

JF - Japanese Journal of Applied Physics

IS - 2

M1 - 028005

ER -

Microscopic fractures shown inside tablets after impact

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