Morbid obesity influences the nocturnal electrocardiogram wave and interval durations among suspected sleep apnea patients

Samu Kainulainen, Aaron Suni, Jukka A. Lipponen, Antti Kulkas, Brett Duce, Henri Korkalainen, Sami Nikkonen, Saara Sillanmäki

    Research output: Contribution to journalArticleScientificpeer-review

    2 Downloads (Pure)

    Abstract

    Background: Obesity is a global issue with a major impact on cardiovascular health. This study explores how obesity influences nocturnal cardiac electrophysiology in suspected obstructive sleep apnea (OSA) patients. Methods: We randomly selected 12 patients from each of the five World Health Organization body mass index (BMI) classifications groups (ntotal = 60) while keeping the group's age and sex matched. We evaluated 1965 nocturnal electrocardiography (ECG) samples (10 s) using modified lead II recorded during normal saturation conditions. R-wave peaks were detected and confirmed using dedicated software, with the exclusion of ventricular extrasystoles and artifacts. The duration of waves and intervals was manually marked. The average electric potential graphs were computed for each segment. Thresholds for abnormal ECG waveforms were P-wave > 120 ms, PQ interval > 200 ms, QRS complex > 120 ms for, and QTc > 440 ms. Results: Obesity was significantly (p <.05) associated with prolonged conduction times. Compared to the normal weight (18.5 ≤ BMI < 25) group, the morbidly obese patients (BMI ≥ 40) had a significantly longer P-wave duration (101.7 vs. 117.2 ms), PQ interval (175.8 vs. 198.0 ms), QRS interval (89.9 vs. 97.7 ms), and QTc interval (402.8 vs. 421.2 ms). We further examined ECG waveform prolongations related to BMI. Compared to other patient groups, the morbidly obese patients had the highest number of ECG segments with PQ interval (44% of the ECG samples), QRS duration (14%), and QTc duration (20%) above the normal limits. Conclusions: Morbid obesity predisposes patients to prolongation of cardiac conduction times. This might increase the risk of arrhythmias, stroke, and even sudden cardiac death.

    Original languageEnglish
    Article numbere13101
    JournalANNALS OF NONINVASIVE ELECTROCARDIOLOGY
    Volume29
    Issue number1
    Early online date2023
    DOIs
    Publication statusPublished - Jan 2024
    Publication typeA1 Journal article-refereed

    Keywords

    • body mass index
    • electrocardiogram
    • interval duration
    • obesity
    • obstructive sleep apnea
    • wave duration

    Publication forum classification

    • Publication forum level 1

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

    Fingerprint

    Dive into the research topics of 'Morbid obesity influences the nocturnal electrocardiogram wave and interval durations among suspected sleep apnea patients'. Together they form a unique fingerprint.

    Cite this