Multicomponent Petasis-borono Mannich Preparation of Alkylaminophenols and Antimicrobial Activity Studies

Íris Neto, Joana Andrade, Catarina Pinto Reis, Jagadish K. Salunke, Arri Priimagi, Nuno R. Candeias, Patricia Rijo

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    32 Citations (Scopus)
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    Abstract

    In this work we report the antibacterial activity of alkylaminophenols. A series of such compounds was prepared by a multicomponent Petasis-borono Mannich reaction starting from salicylaldehyde and its derivatives. The obtained compounds were tested against a large panel of microorganisms, Gram-positive and Gram-negative bacteria, and a yeast. Among the several tertiary amine derivatives tested, indoline-derived aminophenols containing a nitro group at the para-phenol position showed considerable activity against bacteria tested with minimal inhibitory concentrations as low as 1.36 μm against Staphyloccocus aureus and Mycobacterium smegmatis. Cytotoxicity of the new para-nitrophenol derivatives was observed only at concentrations much higher than those required for antibacterial activity.
    Original languageEnglish
    Pages (from-to)2015-2023
    JournalCHEMMEDCHEM
    Volume11
    Issue number18
    Early online date2016
    DOIs
    Publication statusPublished - Sept 2016
    Publication typeA1 Journal article-refereed

    Publication forum classification

    • Publication forum level 1

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