Abstract
In this work we report the antibacterial activity of alkylaminophenols. A series of such compounds was prepared by a multicomponent Petasis-borono Mannich reaction starting from salicylaldehyde and its derivatives. The obtained compounds were tested against a large panel of microorganisms, Gram-positive and Gram-negative bacteria, and a yeast. Among the several tertiary amine derivatives tested, indoline-derived aminophenols containing a nitro group at the para-phenol position showed considerable activity against bacteria tested with minimal inhibitory concentrations as low as 1.36 μm against Staphyloccocus aureus and Mycobacterium smegmatis. Cytotoxicity of the new para-nitrophenol derivatives was observed only at concentrations much higher than those required for antibacterial activity.
Original language | English |
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Pages (from-to) | 2015-2023 |
Journal | CHEMMEDCHEM |
Volume | 11 |
Issue number | 18 |
Early online date | 2016 |
DOIs | |
Publication status | Published - Sept 2016 |
Publication type | A1 Journal article-refereed |
Publication forum classification
- Publication forum level 1