Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI

Denise Bechet, Florent Auger, Pierre Couleaud, Eric Marty, Laura Ravasi, Nicolas Durieux, Corinne Bonnet, François Plénat, Céline Frochot, Serge Mordon, Olivier Tillement, Régis Vanderesse, François Lux, Pascal Perriat, François Guillemin, Muriel Barberi-Heyob

    Research output: Contribution to journalArticleScientificpeer-review

    52 Citations (Scopus)

    Abstract

    Photodynamic therapy (PDT) for brain tumors appears to be complementary to conventional treatments. A number of studies show the major role of the vascular effect in the tumor eradication by PDT. For interstitial PDT (iPDT) of brain tumors guided by real-time imaging, multifunctional nanoparticles consisting of a surface-localized tumor vasculature targeting neuropilin-1 (NRP-1) peptide and encapsulated photosensitizer and magnetic resonance imaging (MRI) contrast agents, have been designed. Nanoplatforms confer photosensitivity to cells and demonstrate a molecular affinity to NRP-1. Intravenous injection into rats bearing intracranial glioma exhibited a dynamic contrast-enhanced MRI for angiogenic endothelial cells lining the neovessels mainly located in the peripheral tumor. By using MRI completed by NRP-1 protein expression of the tumor and brain adjacent to tumor tissues, we checked the selectivity of the nanoparticles. This study represents the first in vivo proof of concept of closed-head iPDT guided by real-time MRI using targeted ultrasmall nanoplatforms.

    Original languageEnglish
    Pages (from-to)657-670
    Number of pages14
    JournalNANOMEDICINE: NANOTECHNOLOGY BIOLOGY AND MEDICINE
    Volume11
    Issue number3
    DOIs
    Publication statusPublished - 2015
    Publication typeA1 Journal article-refereed

    Keywords

    • Brain tumor
    • iPDT
    • Multifunctional nanoplatforms
    • Real-time MRI
    • Targeting

    ASJC Scopus subject areas

    • Molecular Medicine
    • Bioengineering
    • Biomedical Engineering
    • General Materials Science
    • Medicine (miscellaneous)
    • Pharmaceutical Science
    • General Medicine

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