Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy

A.P. Nath; S.C. Ritchie; N.F. Grinberg; H.H.-F. Tang; Q.Q. Huang; S.M. Teo; A.V. Ahola-Olli; P. Würtz; A.S. Havulinna; K. Santalahti; N. Pitkänen; T. Lehtimäki; M. Kähönen; L.-P. Lyytikäinen; E. Raitoharju; I. Seppälä; A.-P. Sarin; S. Ripatti; A. Palotie; M. Perola; J.S. Viikari; S. Jalkanen; M. Maksimow; M. Salmi; C. Wallace; O.T. Raitakari; V. Salomaa; G. Abraham; J. Kettunen; M. Inouye

doi:10.1016/j.ajhg.2019.10.001

Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy

A.P. Nath, S.C. Ritchie, N.F. Grinberg, H.H.-F. Tang, Q.Q. Huang, S.M. Teo, A.V. Ahola-Olli, P. Würtz, A.S. Havulinna, K. Santalahti, N. Pitkänen, T. Lehtimäki, M. Kähönen, L.-P. Lyytikäinen, E. Raitoharju, I. Seppälä, A.-P. Sarin, S. Ripatti, A. Palotie, M. PerolaJ.S. Viikari, S. Jalkanen, M. Maksimow, M. Salmi, C. Wallace, O.T. Raitakari, V. Salomaa, G. Abraham, J. Kettunen, M. Inouye

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

Original language	English
Pages (from-to)	1076-1090
Journal	AMERICAN JOURNAL OF HUMAN GENETICS
Volume	105
Issue number	6
DOIs	https://doi.org/10.1016/j.ajhg.2019.10.001
Publication status	Published - 2019
Publication type	A1 Journal article-refereed

Keywords

GWAS
blood cell traits
cardiometabolic diseases
colocalisation analysis
cytokines
eQTLs
metabolites
multivariate analysis
protein QTLs

Publication forum classification

Publication forum level 3

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10.1016/j.ajhg.2019.10.001

Cite this

Nath, A. P., Ritchie, S. C., Grinberg, N. F., Tang, HH-F., Huang, Q. Q., Teo, S. M., Ahola-Olli, A. V., Würtz, P., Havulinna, A. S., Santalahti, K., Pitkänen, N., Lehtimäki, T., Kähönen, M., Lyytikäinen, L-P., Raitoharju, E., Seppälä, I., Sarin, A-P., Ripatti, S., Palotie, A., ... Inouye, M. (2019). Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy. AMERICAN JOURNAL OF HUMAN GENETICS, 105(6), 1076-1090. https://doi.org/10.1016/j.ajhg.2019.10.001

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title = "Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy",

keywords = "GWAS, blood cell traits, cardiometabolic diseases, colocalisation analysis, cytokines, eQTLs, metabolites, multivariate analysis, protein QTLs, GWAS, blood cell traits, cardiometabolic diseases, colocalisation analysis, cytokines, eQTLs, metabolites, multivariate analysis, protein QTLs",

author = "A.P. Nath and S.C. Ritchie and N.F. Grinberg and H.H.-F. Tang and Q.Q. Huang and S.M. Teo and A.V. Ahola-Olli and P. W{\"u}rtz and A.S. Havulinna and K. Santalahti and N. Pitk{\"a}nen and T. Lehtim{\"a}ki and M. K{\"a}h{\"o}nen and L.-P. Lyytik{\"a}inen and E. Raitoharju and I. Sepp{\"a}l{\"a} and A.-P. Sarin and S. Ripatti and A. Palotie and M. Perola and J.S. Viikari and S. Jalkanen and M. Maksimow and M. Salmi and C. Wallace and O.T. Raitakari and V. Salomaa and G. Abraham and J. Kettunen and M. Inouye",

year = "2019",

doi = "10.1016/j.ajhg.2019.10.001",

language = "English",

volume = "105",

pages = "1076--1090",

journal = "AMERICAN JOURNAL OF HUMAN GENETICS",

issn = "0002-9297",

publisher = "Elsevier",

number = "6",

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Nath, AP, Ritchie, SC, Grinberg, NF, Tang, HH-F, Huang, QQ, Teo, SM, Ahola-Olli, AV, Würtz, P, Havulinna, AS, Santalahti, K, Pitkänen, N, Lehtimäki, T , Kähönen, M , Lyytikäinen, L-P , Raitoharju, E, Seppälä, I, Sarin, A-P, Ripatti, S, Palotie, A, Perola, M, Viikari, JS, Jalkanen, S, Maksimow, M, Salmi, M, Wallace, C, Raitakari, OT, Salomaa, V, Abraham, G, Kettunen, J & Inouye, M 2019, 'Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy', AMERICAN JOURNAL OF HUMAN GENETICS, vol. 105, no. 6, pp. 1076-1090. https://doi.org/10.1016/j.ajhg.2019.10.001

TY - JOUR

T1 - Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy

AU - Nath, A.P.

AU - Ritchie, S.C.

AU - Grinberg, N.F.

AU - Tang, H.H.-F.

AU - Huang, Q.Q.

AU - Teo, S.M.

AU - Ahola-Olli, A.V.

AU - Würtz, P.

AU - Havulinna, A.S.

AU - Santalahti, K.

AU - Pitkänen, N.

AU - Lehtimäki, T.

AU - Kähönen, M.

AU - Lyytikäinen, L.-P.

AU - Raitoharju, E.

AU - Seppälä, I.

AU - Sarin, A.-P.

AU - Ripatti, S.

AU - Palotie, A.

AU - Perola, M.

AU - Viikari, J.S.

AU - Jalkanen, S.

AU - Maksimow, M.

AU - Salmi, M.

AU - Wallace, C.

AU - Raitakari, O.T.

AU - Salomaa, V.

AU - Abraham, G.

AU - Kettunen, J.

AU - Inouye, M.

PY - 2019

Y1 - 2019

KW - GWAS

KW - blood cell traits

KW - cardiometabolic diseases

KW - colocalisation analysis

KW - cytokines

KW - eQTLs

KW - metabolites

KW - multivariate analysis

KW - protein QTLs

KW - GWAS

KW - blood cell traits

KW - cardiometabolic diseases

KW - colocalisation analysis

KW - cytokines

KW - eQTLs

KW - metabolites

KW - multivariate analysis

KW - protein QTLs

U2 - 10.1016/j.ajhg.2019.10.001

DO - 10.1016/j.ajhg.2019.10.001

M3 - Article

SN - 0002-9297

VL - 105

SP - 1076

EP - 1090

JO - AMERICAN JOURNAL OF HUMAN GENETICS

JF - AMERICAN JOURNAL OF HUMAN GENETICS

IS - 6

ER -