Nature-derived microbiota exposure as a novel immunomodulatory approach

N Nurminen; J Lin; M Grönroos; R Puhakka; L Kramna; HK Vari; H Viskari; S Oikarinen; M Roslund; A Parajuli; I Tyni; O Cinek; O Laitinen; H Hyöty; A Sinkkonen

doi:10.2217/fmb-2017-0286

Nature-derived microbiota exposure as a novel immunomodulatory approach

N Nurminen, J Lin, M Grönroos, R Puhakka, L Kramna, HK Vari, H Viskari, S Oikarinen, M Roslund, A Parajuli, I Tyni, O Cinek, O Laitinen, H Hyöty, A Sinkkonen

Department of Clinical Microbiology

Research output: Contribution to journal › Article › Scientific › peer-review

62 Citations (Scopus)

Abstract

Aim: Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material. Materials & methods: We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material. Results: The method was safe and feasible; exposure was associated with an increase in gut microbial diversity. Conclusion: If these findings are reproduced in larger studies nature-derived microbial exposure strategies could be further developed for testing their efficacy in the treatment and prevention of immune-mediated diseases.

Original language	English
Pages (from-to)	737-744
Journal	Future microbiology
Volume	13
Issue number	7
DOIs	https://doi.org/10.2217/fmb-2017-0286
Publication status	Published - 2018
Publication type	A1 Journal article-refereed

Keywords

Immune-mediated diseases
Microbial diversity
microbiome
16S rRNA gene sequencing
immune system
biodiversity hypothesis
gut microbiota
skin microbiota

Publication forum classification

Publication forum level 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fmb-2017-0286

http://urn.fi/urn:nbn:fi:uta-201807062273Licence: Other

Cite this

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title = "Nature-derived microbiota exposure as a novel immunomodulatory approach",

abstract = "Aim: Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material. Materials & methods: We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material. Results: The method was safe and feasible; exposure was associated with an increase in gut microbial diversity. Conclusion: If these findings are reproduced in larger studies nature-derived microbial exposure strategies could be further developed for testing their efficacy in the treatment and prevention of immune-mediated diseases.",

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T1 - Nature-derived microbiota exposure as a novel immunomodulatory approach

AU - Nurminen, N

AU - Lin, J

AU - Grönroos, M

AU - Puhakka, R

AU - Kramna, L

AU - Vari, HK

AU - Viskari, H

AU - Oikarinen, S

AU - Roslund, M

AU - Parajuli, A

AU - Tyni, I

AU - Cinek, O

AU - Laitinen, O

AU - Hyöty, H

AU - Sinkkonen, A

PY - 2018

Y1 - 2018

N2 - Aim: Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material. Materials & methods: We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material. Results: The method was safe and feasible; exposure was associated with an increase in gut microbial diversity. Conclusion: If these findings are reproduced in larger studies nature-derived microbial exposure strategies could be further developed for testing their efficacy in the treatment and prevention of immune-mediated diseases.

AB - Aim: Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material. Materials & methods: We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material. Results: The method was safe and feasible; exposure was associated with an increase in gut microbial diversity. Conclusion: If these findings are reproduced in larger studies nature-derived microbial exposure strategies could be further developed for testing their efficacy in the treatment and prevention of immune-mediated diseases.

KW - Immune-mediated diseases

KW - Microbial diversity

KW - microbiome

KW - 16S rRNA gene sequencing

KW - immune system

KW - biodiversity hypothesis

KW - gut microbiota

KW - skin microbiota

U2 - 10.2217/fmb-2017-0286

DO - 10.2217/fmb-2017-0286

M3 - Article

SN - 1746-0913

VL - 13

SP - 737

EP - 744

JO - Future microbiology

JF - Future microbiology

IS - 7

ER -

Nature-derived microbiota exposure as a novel immunomodulatory approach

Abstract

Keywords

Publication forum classification

UN SDGs

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