TY - JOUR
T1 - Neurocognitive outcome in young adults born late-preterm
AU - Heinonen, Kati
AU - Lahti, Jari
AU - Sammallahti, Sara
AU - Wolke, Dieter
AU - Lano, Aulikki
AU - Andersson, Sture
AU - Pesonen, Anu Katriina
AU - Eriksson, Johan G.
AU - Kajantie, Eero
AU - Raikkonen, Katri
N1 - Funding Information:
Childhood follow-up was financially supported by the Bundesministerium für Forschung und Technik (Federal Government of Germany, Ministry of Science and Technology) program grants PKE 4 and JUG 14 (FKZs 0706224, 0706564, and 01EP9504) to Klaus Riegel, DW, and Barbara Ohrt; adulthood follow-up was financially supported by program grants from the Academy of Finland (to JGE, KR, and EK); Horizon 2020 Award SC1-2016-RTD-733280 RECAP (to DW, EK and KR); the work of AL was supported by the Foundation for Pediatric Research; the work of KH and JL was supported by the Academy of Finland postdoctoral grant; the work of SS was supported by the Doctoral School of Clinical Research; JGE was also supported by a grant from Samfundet Folkhälsan; SA from the Päivikki and Sakari Sohlberg Foundation and Finska Läkaresällskapet; EK by the Foundation for Pediatric Research, Juho Vainio Foundation, and Novo Nordisk Foundation, and Sigrid Juselius Foundation; and KR and EK by Signe and Ane Gyllenberg Foundation. Funders did not have any role in study design, data collection, data analysis, manuscript preparation, and/or publication decisions. Special thanks to Juha Peltola, Timo Vartia, and the numerous other people who collected the data and kept the sample intact in childhood and adulthood follow-ups. The authors have stated that they had no interests that might be perceived as posing a conflict or bias.
Funding Information:
Childhood follow-up was financially supported by the Bun-desministerium fu€r Forschung und Technik (Federal Government of Germany, Ministry of Science and Technology) program grants PKE 4 and JUG 14 (FKZs 0706224, 0706564, and 01EP9504) to Klaus Riegel, DW, and Barbara Ohrt; adulthood follow-up was financially supported by program grants from the Academy of Finland (to JGE, KR, and EK); Horizon 2020 Award SC1-2016-RTD-733280 RECAP (to DW, EK and KR); the work of AL was supported by the Foundation for Pediatric Research; the work of KH and JL was supported by the Academy of Finland postdoctoral grant; the work of SS was supported by the Doctoral School of Clinical Research; JGE was also supported by a grant from Samfundet Folkh€alsan; SA from the P€aivikki and Sakari Sohlberg Foundation and Finska L€akares€allskapet; EK by the Foundation for Pediatric Research, Juho Vainio Foundation, and Novo Nordisk Foundation, and Sigrid Juselius Foundation; and KR and EK by Signe and Ane Gyllenberg Foundation. Funders did not have any role in study design, data collection, data analysis, manuscript preparation, and/or publication decisions. Special thanks to Juha Peltola, Timo Vartia, and the numerous other people who collected the data and kept the sample intact in childhood and adulthood follow-ups. The authors have stated that they had no interests that might be perceived as posing a conflict or bias.
Publisher Copyright:
© 2017 Mac Keith Press
PY - 2018/3
Y1 - 2018/3
N2 - Aim: This study examined whether late-preterm birth (34+0 to 36+6wks+d gestational age) was associated with neurocognitive deficit in young adulthood, and whether small for gestational age (SGA) birth amplified any adversity. Method: Participants derived from the prospective regional cohort study, the Arvo Ylppö Longitudinal Study (n=786; 398 females, 388 males) (mean age 25y 4mo, SD 8mo), born 1985 to 1986 late-preterm (n=119; 21 SGA, <−2 SD) and at term (37+0 to 41+6wks+d; n=667; 28 SGA) underwent tests of intelligence, executive functioning, attention, and memory, and reported their education. Results: Those born late-preterm scored −3.71 (95% confidence interval [CI] −6.71 to −0.72) and −3.11 (95% CI −6.01 to −0.22) points lower on Full-scale and Verbal IQ than peers born at term. Compared with those born at term and appropriate for gestational age (≥−2 to <2 SD) Full-scale, Verbal, and Performance IQ scores of those born late-preterm and SGA were −9.45 to −11.84 points lower. After adjustments, differences were rendered non-significant, except that scores in Full-scale and Performance IQ remained lower among those born late-preterm and SGA. Interpretation: Late-preterm birth, per se, may not increase the risk of poorer neurocognitive functioning in adulthood. But the double burden of being born late-preterm and SGA seems to increase this risk. What this paper adds: Late-preterm birth did not increase the risk of poorer neurocognitive functioning in adulthood. But the double burden of being born late-preterm and being small for gestational age did increase this risk.
AB - Aim: This study examined whether late-preterm birth (34+0 to 36+6wks+d gestational age) was associated with neurocognitive deficit in young adulthood, and whether small for gestational age (SGA) birth amplified any adversity. Method: Participants derived from the prospective regional cohort study, the Arvo Ylppö Longitudinal Study (n=786; 398 females, 388 males) (mean age 25y 4mo, SD 8mo), born 1985 to 1986 late-preterm (n=119; 21 SGA, <−2 SD) and at term (37+0 to 41+6wks+d; n=667; 28 SGA) underwent tests of intelligence, executive functioning, attention, and memory, and reported their education. Results: Those born late-preterm scored −3.71 (95% confidence interval [CI] −6.71 to −0.72) and −3.11 (95% CI −6.01 to −0.22) points lower on Full-scale and Verbal IQ than peers born at term. Compared with those born at term and appropriate for gestational age (≥−2 to <2 SD) Full-scale, Verbal, and Performance IQ scores of those born late-preterm and SGA were −9.45 to −11.84 points lower. After adjustments, differences were rendered non-significant, except that scores in Full-scale and Performance IQ remained lower among those born late-preterm and SGA. Interpretation: Late-preterm birth, per se, may not increase the risk of poorer neurocognitive functioning in adulthood. But the double burden of being born late-preterm and SGA seems to increase this risk. What this paper adds: Late-preterm birth did not increase the risk of poorer neurocognitive functioning in adulthood. But the double burden of being born late-preterm and being small for gestational age did increase this risk.
U2 - 10.1111/dmcn.13616
DO - 10.1111/dmcn.13616
M3 - Article
C2 - 29178266
AN - SCOPUS:85042228714
VL - 60
SP - 267
EP - 274
IS - 3
ER -