Neuromuscular pathology in mice lacking alpha-synuclein

Anssi Pelkonen, Leonid Yavich

    Research output: Contribution to journalArticleScientificpeer-review

    15 Citations (Scopus)

    Abstract

    This work was undertaken in order to study the possible role of alpha-synuclein in the function of the neuro-muscular junction in skeletal muscles. Repeated stimulation of skeletal muscle motor neurons revealed signs of neuromuscular pathology in alpha-synuclein null mutated (C57Bl/6JOlaHsd) and knockout (B6:129X1-Sncatm1Rosl/J) mice. This stimulation produced repetitive compound muscle action potentials in both lines of alpha-synuclein deficient mice. Muscle strength and muscle coordination during ambulation were unaffected, though motor learning was slower in alpha-synuclein deficient mice in the Rotarod test. We conclude that alpha-synuclein may play a role in acetylcholine compartmentalization at the neuromuscular junction, and in the fine control of activity of skeletal muscles.

    Original languageEnglish
    Pages (from-to)350-353
    Number of pages4
    JournalNeuroscience Letters
    Volume487
    Issue number3
    DOIs
    Publication statusPublished - 2011
    Publication typeA1 Journal article-refereed

    Keywords

    • Alpha-synuclein
    • Electromyography
    • Knockout mice
    • Neuromuscular junction
    • Skeletal muscles

    Publication forum classification

    • No publication forum level

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