Abstract
This work was undertaken in order to study the possible role of alpha-synuclein in the function of the neuro-muscular junction in skeletal muscles. Repeated stimulation of skeletal muscle motor neurons revealed signs of neuromuscular pathology in alpha-synuclein null mutated (C57Bl/6JOlaHsd) and knockout (B6:129X1-Sncatm1Rosl/J) mice. This stimulation produced repetitive compound muscle action potentials in both lines of alpha-synuclein deficient mice. Muscle strength and muscle coordination during ambulation were unaffected, though motor learning was slower in alpha-synuclein deficient mice in the Rotarod test. We conclude that alpha-synuclein may play a role in acetylcholine compartmentalization at the neuromuscular junction, and in the fine control of activity of skeletal muscles.
| Original language | English |
|---|---|
| Pages (from-to) | 350-353 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 487 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2011 |
| Publication type | A1 Journal article-refereed |
Keywords
- Alpha-synuclein
- Electromyography
- Knockout mice
- Neuromuscular junction
- Skeletal muscles
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