Neuron–Glia Interactions and Brain Circuits

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    Abstract

    Recent evidence suggests that glial cells take an active role in a number of brain functions that were previously attributed solely to neurons. For example, astrocytes, one type of glial cells, have been shown to promote coordinated activation of neuronal networks, modulate sensory-evoked neuronal network activity, and influence brain state transitions during development. This reinforces the idea that astrocytes not only provide the “housekeeping” for the neurons, but that they also play a vital role in supporting and expanding the functions of brain circuits and networks. Despite this accumulated knowledge, the field of computational neuroscience has mostly focused on modeling neuronal functions, ignoring the glial cells and the interactions they have with the neurons. In this chapter, we introduce the biology of neuron–glia interactions, summarize the existing computational models and tools, and emphasize the glial properties that may be important in modeling brain functions in the future.
    Original languageEnglish
    Title of host publicationComputational Modelling of the Brain
    Subtitle of host publicationModelling Approaches to Cells, Circuits and Networks
    EditorsMichele Giugliano, Mario Negrello, Daniele Linaro
    PublisherSpringer
    Pages87-103
    Number of pages17
    ISBN (Electronic)978-3-030-89439-9
    ISBN (Print)978-3-030-89438-2
    DOIs
    Publication statusPublished - 27 Apr 2022
    Publication typeA3 Book chapter

    Publication series

    NameAdvances in Experimental Medicine and Biology
    Volume1359
    ISSN (Print)0065-2598
    ISSN (Electronic)0065-2598

    Publication forum classification

    • Publication forum level 1

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