New dirhodium complex with activity towards colorectal cancer

Raquel F. M. Frade, Nuno R. Candeias, Catarina M. M. Duarte, Vania Andre, M. Teresa Duarte, Pedro M. P. Gois, Carlos A. M. Afonso

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)

Abstract

A novel dirhodium complex (Rh(2)(L-PheAla)(2)(OAc)(2) is reported with strong activity towards human colon adenocarcinoma cells. Its effect was not accompanied by generation of reactive oxygen species (ROS) neither by activation of caspase-3. (C) 2010 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)3413-3415
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number11
DOIs
Publication statusPublished - 1 Jun 2010
Externally publishedYes
Publication typeA1 Journal article-refereed

Keywords

  • Dirhodium complex
  • Human colon adenocarcinoma cells
  • ANTITUMOR-ACTIVITY
  • IN-VITRO
  • RHODIUM(II) CARBOXYLATES
  • CELL-DEATH
  • BIOLOGICAL-ACTIVITY
  • STRUCTURAL EVIDENCE
  • CRYSTAL-STRUCTURES
  • GUANINE BASES
  • METAL-BINDING
  • CISPLATIN

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