No association in maternal serum levels of TMAO and its precursors in pre-eclampsia and in non-complicated pregnancies

Tiina Jääskeläinen; Olli Kärkkäinen; Seppo Heinonen; Kati Hanhineva; Hannele Laivuori

doi:10.1016/j.preghy.2022.02.008

No association in maternal serum levels of TMAO and its precursors in pre-eclampsia and in non-complicated pregnancies

Tiina Jääskeläinen, Olli Kärkkäinen, Seppo Heinonen, Kati Hanhineva, Hannele Laivuori

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Abstract

Only a few studies have explored the role of microbiota-dependent metabolite trimethylamine N-oxide (TMAO) in non-complicated pregnancy and in pre-eclampsia (PE). We enrolled 139 PE and 29 healthy pregnant women in a nested case control study. We hypothesized that elevated levels of circulating TMAO and its precursors choline and glycine betaine in the late second or in third trimester might contribute to the PE and are associated with the onset of the disease and clinical features such as elevated blood pressure. The association with a few available lifestyle factors (use of fish and physical activity) was also evaluated. In contrast with the previous findings, there was no difference in TMAO concentration between PE and healthy women. In addition, TMAO concentration was not associated with any of the PE related clinical features, angiogenic or inflammatory markers. In future, it is crucial to obtain longitudinal data on TMAO in both non-complicated and in PE pregnancies before we could have more detailed understanding of TMAO.

Original language	English
Pages (from-to)	74-80
Number of pages	7
Journal	PREGNANCY HYPERTENSION
Volume	28
DOIs	https://doi.org/10.1016/j.preghy.2022.02.008
Publication status	Published - Jun 2022
Publication type	A1 Journal article-refereed

Funding

Funding was received from the Competitive State Research Financing of the Expert Responsibility are of Helsinki University Hospital (TYH2018305 and TYH2021308), Juho Vainio Foundation, Jane and Aatos Erkko Foundation, Päivikki and Sakari Sohlberg Foundation, Academy of Finland (grants no 121196, 134957, 278941, 277986, 321716), Research Funds of the University of Helsinki, Finnish Medical Foundation, Finska Läkaresällskapet, Emil Aaltonen Foundation, Sigrid Jusélius Foundation and ERA-NET NEURON Grant no 334814. We appreciate the expert technical assistance of Eija Kortelainen and late Susanna Meht?l? and contribution of the members and assisting personnel of the FINNPEC Study Group. Swedish Metabolomics Centre, Ume?, Sweden (www.swedishmetabolomicscentre.se) is acknowledged for the measurement of TMAO panels by LC?MS.

Keywords

LC–MS
Preeclampsia
Pregnancy
TMAO

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Internal Medicine
Obstetrics and Gynaecology

Access to Document

10.1016/j.preghy.2022.02.008Licence: CC BY

1-s2.0-S2210778922000290-mainFinal published version, 511 KBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202205185054Licence: CC BY

Cite this

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title = "No association in maternal serum levels of TMAO and its precursors in pre-eclampsia and in non-complicated pregnancies",

abstract = "Only a few studies have explored the role of microbiota-dependent metabolite trimethylamine N-oxide (TMAO) in non-complicated pregnancy and in pre-eclampsia (PE). We enrolled 139 PE and 29 healthy pregnant women in a nested case control study. We hypothesized that elevated levels of circulating TMAO and its precursors choline and glycine betaine in the late second or in third trimester might contribute to the PE and are associated with the onset of the disease and clinical features such as elevated blood pressure. The association with a few available lifestyle factors (use of fish and physical activity) was also evaluated. In contrast with the previous findings, there was no difference in TMAO concentration between PE and healthy women. In addition, TMAO concentration was not associated with any of the PE related clinical features, angiogenic or inflammatory markers. In future, it is crucial to obtain longitudinal data on TMAO in both non-complicated and in PE pregnancies before we could have more detailed understanding of TMAO.",

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note = "Funding Information: Funding was received from the Competitive State Research Financing of the Expert Responsibility are of Helsinki University Hospital (TYH2018305 and TYH2021308), Juho Vainio Foundation, Jane and Aatos Erkko Foundation, P{\"a}ivikki and Sakari Sohlberg Foundation, Academy of Finland (grants no 121196, 134957, 278941, 277986, 321716), Research Funds of the University of Helsinki, Finnish Medical Foundation, Finska L{\"a}kares{\"a}llskapet, Emil Aaltonen Foundation, Sigrid Jus{\'e}lius Foundation and ERA-NET NEURON Grant no 334814. Funding Information: We appreciate the expert technical assistance of Eija Kortelainen and late Susanna Meht?l? and contribution of the members and assisting personnel of the FINNPEC Study Group. Swedish Metabolomics Centre, Ume?, Sweden (www.swedishmetabolomicscentre.se) is acknowledged for the measurement of TMAO panels by LC?MS. Publisher Copyright: {\textcopyright} 2022",

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AU - Kärkkäinen, Olli

AU - Heinonen, Seppo

AU - Hanhineva, Kati

AU - Laivuori, Hannele

N1 - Funding Information: Funding was received from the Competitive State Research Financing of the Expert Responsibility are of Helsinki University Hospital (TYH2018305 and TYH2021308), Juho Vainio Foundation, Jane and Aatos Erkko Foundation, Päivikki and Sakari Sohlberg Foundation, Academy of Finland (grants no 121196, 134957, 278941, 277986, 321716), Research Funds of the University of Helsinki, Finnish Medical Foundation, Finska Läkaresällskapet, Emil Aaltonen Foundation, Sigrid Jusélius Foundation and ERA-NET NEURON Grant no 334814. Funding Information: We appreciate the expert technical assistance of Eija Kortelainen and late Susanna Meht?l? and contribution of the members and assisting personnel of the FINNPEC Study Group. Swedish Metabolomics Centre, Ume?, Sweden (www.swedishmetabolomicscentre.se) is acknowledged for the measurement of TMAO panels by LC?MS. Publisher Copyright: © 2022

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N2 - Only a few studies have explored the role of microbiota-dependent metabolite trimethylamine N-oxide (TMAO) in non-complicated pregnancy and in pre-eclampsia (PE). We enrolled 139 PE and 29 healthy pregnant women in a nested case control study. We hypothesized that elevated levels of circulating TMAO and its precursors choline and glycine betaine in the late second or in third trimester might contribute to the PE and are associated with the onset of the disease and clinical features such as elevated blood pressure. The association with a few available lifestyle factors (use of fish and physical activity) was also evaluated. In contrast with the previous findings, there was no difference in TMAO concentration between PE and healthy women. In addition, TMAO concentration was not associated with any of the PE related clinical features, angiogenic or inflammatory markers. In future, it is crucial to obtain longitudinal data on TMAO in both non-complicated and in PE pregnancies before we could have more detailed understanding of TMAO.

AB - Only a few studies have explored the role of microbiota-dependent metabolite trimethylamine N-oxide (TMAO) in non-complicated pregnancy and in pre-eclampsia (PE). We enrolled 139 PE and 29 healthy pregnant women in a nested case control study. We hypothesized that elevated levels of circulating TMAO and its precursors choline and glycine betaine in the late second or in third trimester might contribute to the PE and are associated with the onset of the disease and clinical features such as elevated blood pressure. The association with a few available lifestyle factors (use of fish and physical activity) was also evaluated. In contrast with the previous findings, there was no difference in TMAO concentration between PE and healthy women. In addition, TMAO concentration was not associated with any of the PE related clinical features, angiogenic or inflammatory markers. In future, it is crucial to obtain longitudinal data on TMAO in both non-complicated and in PE pregnancies before we could have more detailed understanding of TMAO.

KW - LC–MS

KW - Preeclampsia

KW - Pregnancy

KW - TMAO

U2 - 10.1016/j.preghy.2022.02.008

DO - 10.1016/j.preghy.2022.02.008

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SN - 2210-7789

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JO - PREGNANCY HYPERTENSION

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ER -

No association in maternal serum levels of TMAO and its precursors in pre-eclampsia and in non-complicated pregnancies

Abstract

Funding

Keywords

Publication forum classification

ASJC Scopus subject areas

Access to Document

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Cite this