Non-coding RNAs in DNA damage and repair

Vivek Sharma; Tom Misteli

doi:10.1016/j.febslet.2013.05.006

Non-coding RNAs in DNA damage and repair

Vivek Sharma, Tom Misteli

Research output: Contribution to journal › Review Article › peer-review

71 Citations (Scopus)

Abstract

Non-coding RNAs (ncRNAs) are increasingly recognized as central players in diverse biological processes. Upon DNA damage, the DNA damage response (DDR) elicits a complex signaling cascade, which includes the induction of multiple ncRNA species. Recent studies indicate that DNA-damage induced ncRNAs contribute to regulation of cell cycle, apoptosis and DNA repair, and thus play a key role in maintaining genome stability. This review summarizes the emerging role of ncRNAs in DNA damage and repair.

Original language	English
Pages (from-to)	1832-1839
Number of pages	8
Journal	FEBS Letters
Volume	587
Issue number	13
DOIs	https://doi.org/10.1016/j.febslet.2013.05.006
Publication status	Published - 27 Jun 2013
Publication type	A2 Review article in a scientific journal

Keywords

Non-coding RNA DNA damage Repair miRNA Long non-coding RNA Genome integrity

ASJC Scopus subject areas

Biochemistry
Biophysics
Cell Biology
Genetics
Molecular Biology
Structural Biology

Access to Document

10.1016/j.febslet.2013.05.006

Cite this

@article{77fd7273c37141c093b61abf8e68212b,

title = "Non-coding RNAs in DNA damage and repair",

abstract = "Non-coding RNAs (ncRNAs) are increasingly recognized as central players in diverse biological processes. Upon DNA damage, the DNA damage response (DDR) elicits a complex signaling cascade, which includes the induction of multiple ncRNA species. Recent studies indicate that DNA-damage induced ncRNAs contribute to regulation of cell cycle, apoptosis and DNA repair, and thus play a key role in maintaining genome stability. This review summarizes the emerging role of ncRNAs in DNA damage and repair.",

keywords = "Non-coding RNA DNA damage Repair miRNA Long non-coding RNA Genome integrity",

author = "Vivek Sharma and Tom Misteli",

year = "2013",

month = jun,

day = "27",

doi = "10.1016/j.febslet.2013.05.006",

language = "English",

volume = "587",

pages = "1832--1839",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "13",

}

TY - JOUR

T1 - Non-coding RNAs in DNA damage and repair

AU - Sharma, Vivek

AU - Misteli, Tom

PY - 2013/6/27

Y1 - 2013/6/27

N2 - Non-coding RNAs (ncRNAs) are increasingly recognized as central players in diverse biological processes. Upon DNA damage, the DNA damage response (DDR) elicits a complex signaling cascade, which includes the induction of multiple ncRNA species. Recent studies indicate that DNA-damage induced ncRNAs contribute to regulation of cell cycle, apoptosis and DNA repair, and thus play a key role in maintaining genome stability. This review summarizes the emerging role of ncRNAs in DNA damage and repair.

AB - Non-coding RNAs (ncRNAs) are increasingly recognized as central players in diverse biological processes. Upon DNA damage, the DNA damage response (DDR) elicits a complex signaling cascade, which includes the induction of multiple ncRNA species. Recent studies indicate that DNA-damage induced ncRNAs contribute to regulation of cell cycle, apoptosis and DNA repair, and thus play a key role in maintaining genome stability. This review summarizes the emerging role of ncRNAs in DNA damage and repair.

KW - Non-coding RNA DNA damage Repair miRNA Long non-coding RNA Genome integrity

UR - http://www.scopus.com/inward/record.url?scp=84878919248&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2013.05.006

DO - 10.1016/j.febslet.2013.05.006

M3 - Review Article

C2 - 23684639

AN - SCOPUS:84878919248

SN - 0014-5793

VL - 587

SP - 1832

EP - 1839

JO - FEBS Letters

JF - FEBS Letters

IS - 13

ER -

Non-coding RNAs in DNA damage and repair

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this