Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile

Ivana Kholová; Elina Haaga; Jaroslav Ludvik; David Kalfert; Marie Ludvikova

doi:10.3390/diagnostics12020250

Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile

Ivana Kholová, Elina Haaga, Jaroslav Ludvik, David Kalfert, Marie Ludvikova

Department of Pathology

Research output: Contribution to journal › Review Article › peer-review

13 Citations (Scopus)

52 Downloads (Pure)

Abstract

Since Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) was introduced as a new thyroid tumour entity, many studies, and meta-analyses on diag-nosing NIFTP have been published. NIFTP-revised histopathological criteria emerged in 2018. NIFTP is defined as a histological entity and its diagnosis requires a careful histological examination. Its molecular profile is similar to follicular-like tumours. Ultrasound features are unable to differentiate NIFTP. NIFTP is not a cytological diagnosis, but it influences the risk of malignancy in several categories of The Bethesda System for Reporting Thyroid Cytopathology terminology.

Original language	English
Article number	250
Number of pages	14
Journal	Diagnostics
Volume	12
Issue number	2
DOIs	https://doi.org/10.3390/diagnostics12020250
Publication status	Published - Jan 2022
Publication type	A2 Review article in a scientific journal

Funding

Funding: This project was funded by VTR grant from Pirkanmaa Hospital District and Pirkanmaa Cancer Foundation (both to I.K.), the Charles University Research Fund (Progres Q28/LF1 [UNCE 204013]) and Operational Programme Research, Development and Education project “Center for Tumor Ecology–Research of the Cancer Microenvironment Supporting Cancer Growth and Spread” (reg. No. CZ.02.1.01./0.0/0.0/16_019/0000785 (both to D.K.), Ministry of Health, Czech Republic– Conceptual development of research organization (Faculty Hospital in Pilsen—FNPI, 00669806) (to J.L.) and by the Charles University Research Fund (Progres Q39) (to M.L.). This project was funded by VTR grant from Pirkanmaa Hospital District and Pirkanmaa Cancer Foundation (both to I.K.), the Charles University Research Fund (Progres Q28/LF1 [UNCE 204013]) and Operational Programme Research, Development and Education project ?Center for Tumor Ecology?Research of the Cancer Microenvironment Supporting Cancer Growth and Spread? (reg. No. CZ.02.1.01./0.0/0.0/16_019/0000785 (both to D.K.), Ministry of Health, Czech Republic? Conceptual development of research organization (Faculty Hospital in Pilsen?FNPI, 00669806) (to J.L.) and by the Charles University Research Fund (Progres Q39) (to M.L.).

Keywords

Cytology
Histopathology
Molecular diagnosis
Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP)
The Bethesda System for Reporting Thyroid Cytopathology
Thyroid gland
Thyroid papillary carcinoma
Ultrasound

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Clinical Biochemistry

Access to Document

10.3390/diagnostics12020250Licence: CC BY

diagnostics-12-00250Final published version, 785 KBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202204294121Licence: CC BY

Cite this

@article{14f791a37ba84b8a8cb20dc6067cf640,

title = "Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile",

abstract = "Since Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) was introduced as a new thyroid tumour entity, many studies, and meta-analyses on diag-nosing NIFTP have been published. NIFTP-revised histopathological criteria emerged in 2018. NIFTP is defined as a histological entity and its diagnosis requires a careful histological examination. Its molecular profile is similar to follicular-like tumours. Ultrasound features are unable to differentiate NIFTP. NIFTP is not a cytological diagnosis, but it influences the risk of malignancy in several categories of The Bethesda System for Reporting Thyroid Cytopathology terminology.",

keywords = "Cytology, Histopathology, Molecular diagnosis, Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP), The Bethesda System for Reporting Thyroid Cytopathology, Thyroid gland, Thyroid papillary carcinoma, Ultrasound",

author = "Ivana Kholov{\'a} and Elina Haaga and Jaroslav Ludvik and David Kalfert and Marie Ludvikova",

note = "Funding Information: Funding: This project was funded by VTR grant from Pirkanmaa Hospital District and Pirkanmaa Cancer Foundation (both to I.K.), the Charles University Research Fund (Progres Q28/LF1 [UNCE 204013]) and Operational Programme Research, Development and Education project “Center for Tumor Ecology–Research of the Cancer Microenvironment Supporting Cancer Growth and Spread” (reg. No. CZ.02.1.01./0.0/0.0/16_019/0000785 (both to D.K.), Ministry of Health, Czech Republic– Conceptual development of research organization (Faculty Hospital in Pilsen—FNPI, 00669806) (to J.L.) and by the Charles University Research Fund (Progres Q39) (to M.L.). Funding Information: This project was funded by VTR grant from Pirkanmaa Hospital District and Pirkanmaa Cancer Foundation (both to I.K.), the Charles University Research Fund (Progres Q28/LF1 [UNCE 204013]) and Operational Programme Research, Development and Education project ?Center for Tumor Ecology?Research of the Cancer Microenvironment Supporting Cancer Growth and Spread? (reg. No. CZ.02.1.01./0.0/0.0/16_019/0000785 (both to D.K.), Ministry of Health, Czech Republic? Conceptual development of research organization (Faculty Hospital in Pilsen?FNPI, 00669806) (to J.L.) and by the Charles University Research Fund (Progres Q39) (to M.L.). Publisher Copyright: Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jan,

doi = "10.3390/diagnostics12020250",

language = "English",

volume = "12",

number = "2",

}

Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile. / Kholová, Ivana; Haaga, Elina; Ludvik, Jaroslav et al.
In: Diagnostics, Vol. 12, No. 2, 250, 01.2022.

Research output: Contribution to journal › Review Article › peer-review

TY - JOUR

T1 - Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP)

T2 - Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile

AU - Kholová, Ivana

AU - Haaga, Elina

AU - Ludvik, Jaroslav

AU - Kalfert, David

AU - Ludvikova, Marie

N1 - Funding Information: Funding: This project was funded by VTR grant from Pirkanmaa Hospital District and Pirkanmaa Cancer Foundation (both to I.K.), the Charles University Research Fund (Progres Q28/LF1 [UNCE 204013]) and Operational Programme Research, Development and Education project “Center for Tumor Ecology–Research of the Cancer Microenvironment Supporting Cancer Growth and Spread” (reg. No. CZ.02.1.01./0.0/0.0/16_019/0000785 (both to D.K.), Ministry of Health, Czech Republic– Conceptual development of research organization (Faculty Hospital in Pilsen—FNPI, 00669806) (to J.L.) and by the Charles University Research Fund (Progres Q39) (to M.L.). Funding Information: This project was funded by VTR grant from Pirkanmaa Hospital District and Pirkanmaa Cancer Foundation (both to I.K.), the Charles University Research Fund (Progres Q28/LF1 [UNCE 204013]) and Operational Programme Research, Development and Education project ?Center for Tumor Ecology?Research of the Cancer Microenvironment Supporting Cancer Growth and Spread? (reg. No. CZ.02.1.01./0.0/0.0/16_019/0000785 (both to D.K.), Ministry of Health, Czech Republic? Conceptual development of research organization (Faculty Hospital in Pilsen?FNPI, 00669806) (to J.L.) and by the Charles University Research Fund (Progres Q39) (to M.L.). Publisher Copyright: Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/1

Y1 - 2022/1

N2 - Since Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) was introduced as a new thyroid tumour entity, many studies, and meta-analyses on diag-nosing NIFTP have been published. NIFTP-revised histopathological criteria emerged in 2018. NIFTP is defined as a histological entity and its diagnosis requires a careful histological examination. Its molecular profile is similar to follicular-like tumours. Ultrasound features are unable to differentiate NIFTP. NIFTP is not a cytological diagnosis, but it influences the risk of malignancy in several categories of The Bethesda System for Reporting Thyroid Cytopathology terminology.

AB - Since Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) was introduced as a new thyroid tumour entity, many studies, and meta-analyses on diag-nosing NIFTP have been published. NIFTP-revised histopathological criteria emerged in 2018. NIFTP is defined as a histological entity and its diagnosis requires a careful histological examination. Its molecular profile is similar to follicular-like tumours. Ultrasound features are unable to differentiate NIFTP. NIFTP is not a cytological diagnosis, but it influences the risk of malignancy in several categories of The Bethesda System for Reporting Thyroid Cytopathology terminology.

KW - Cytology

KW - Histopathology

KW - Molecular diagnosis

KW - Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP)

KW - The Bethesda System for Reporting Thyroid Cytopathology

KW - Thyroid gland

KW - Thyroid papillary carcinoma

KW - Ultrasound

U2 - 10.3390/diagnostics12020250

DO - 10.3390/diagnostics12020250

M3 - Review Article

AN - SCOPUS:85123127693

SN - 2075-4418

VL - 12

JO - Diagnostics

JF - Diagnostics

IS - 2

M1 - 250

ER -

Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile

Abstract

Funding

Keywords

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