TY - JOUR
T1 - Nonrespiratory Diseases in Adults Without and With Asthma by Age at Asthma Diagnosis
AU - Honkamäki, Jasmin
AU - Ilmarinen, Pinja
AU - Hisinger-Mölkänen, Hanna
AU - Tuomisto, Leena E.
AU - Andersén, Heidi
AU - Huhtala, Heini
AU - Sovijärvi, Anssi
AU - Lindqvist, Ari
AU - Backman, Helena
AU - Nwaru, Bright I.
AU - Rönmark, Eva
AU - Lehtimäki, Lauri
AU - Pallasaho, Paula
AU - Piirilä, Päivi
AU - Kankaanranta, Hannu
N1 - Funding Information:
This research is supported by The Foundation of Ida Montin (Kerava, Finland), Allergy Research Foundation (Helsinki, Finland), The Foundation of Väinö and Laina Kivi (Helsinki, Finland), Tampere Tuberculosis Foundation (Tampere, Finland), The Finnish Anti-Tuberculosis Association Foundation (Helsinki, Finland), The Research Foundation of the Pulmonary Diseases (Helsinki, Finland), Finnish Cultural Foundation (Pirkanmaa, Finland), The Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital (Tampere, Finland), The Medical Research Fund of Seinäjoki Central Hospital (Seinäjoki, Finland), NordForsk (Oslo, Norway), and Nummela Sanatorium Foundation (Helsinki, Finland). None of the sponsors had any involvement in the planning, execution, drafting, or write-up of this study.
Publisher Copyright:
© 2022 The Authors
PY - 2023
Y1 - 2023
N2 - Background: Chronic nonrespiratory diseases are seemingly more prevalent in subjects with than without asthma, and asthma seems to differentiate by age of onset. However, studies with comparison of nonrespiratory diseases in subjects with and without asthma, considering asthma age of onset, are scarce. Objective: To compare the quantity and type of chronic nonrespiratory diseases in adults with and without asthma considering age at asthma diagnosis. Methods: In 2016, a FinEsS questionnaire was sent to 16,000 20- to 69-year-old adults randomly selected in Helsinki and Western Finland populations. Physician-diagnosed asthma was categorized to early (0-11), intermediate (12-39), and late-diagnosed (40-69 years). Results: A total of 8199 (51.5%) responded, and 842 (10.3%) reported asthma and age at diagnosis. In age and sex-adjusted binary logistic regression model, the most represented nonrespiratory disease was treated gastroesophageal reflux disease in early-diagnosed (odds ratio, 1.93; 95% CI, 1.17-3.19; P =.011) and osteoporosis in both intermediate-diagnosed (odds ratio, 3.45; 95% CI, 2.01-5.91; P <.001) and late-diagnosed asthma (odds ratio, 2.91; 95% CI, 1.77-4.79; P <.001), compared with subjects without asthma. In addition, gastroesophageal reflux disease, depression, sleep apnea, painful condition, and obesity were significantly more common in intermediate- and late-diagnosed asthma compared with without asthma, and similarly anxiety or panic disorder in intermediate-diagnosed and hypertension, severe cardiovascular disease, arrhythmia, and diabetes in late-diagnosed asthma. In age-adjusted analyses, having 3 or more nonrespiratory diseases was more common in intermediate (12.1%) and late-diagnosed asthma (36.2%) versus without asthma (10.4%) (both P <.001). Conclusions: Nonrespiratory diseases were more common in adults with asthma than in adults without asthma. The type of nonrespiratory diseases differed, and their frequency increased by increasing age at asthma diagnosis.
AB - Background: Chronic nonrespiratory diseases are seemingly more prevalent in subjects with than without asthma, and asthma seems to differentiate by age of onset. However, studies with comparison of nonrespiratory diseases in subjects with and without asthma, considering asthma age of onset, are scarce. Objective: To compare the quantity and type of chronic nonrespiratory diseases in adults with and without asthma considering age at asthma diagnosis. Methods: In 2016, a FinEsS questionnaire was sent to 16,000 20- to 69-year-old adults randomly selected in Helsinki and Western Finland populations. Physician-diagnosed asthma was categorized to early (0-11), intermediate (12-39), and late-diagnosed (40-69 years). Results: A total of 8199 (51.5%) responded, and 842 (10.3%) reported asthma and age at diagnosis. In age and sex-adjusted binary logistic regression model, the most represented nonrespiratory disease was treated gastroesophageal reflux disease in early-diagnosed (odds ratio, 1.93; 95% CI, 1.17-3.19; P =.011) and osteoporosis in both intermediate-diagnosed (odds ratio, 3.45; 95% CI, 2.01-5.91; P <.001) and late-diagnosed asthma (odds ratio, 2.91; 95% CI, 1.77-4.79; P <.001), compared with subjects without asthma. In addition, gastroesophageal reflux disease, depression, sleep apnea, painful condition, and obesity were significantly more common in intermediate- and late-diagnosed asthma compared with without asthma, and similarly anxiety or panic disorder in intermediate-diagnosed and hypertension, severe cardiovascular disease, arrhythmia, and diabetes in late-diagnosed asthma. In age-adjusted analyses, having 3 or more nonrespiratory diseases was more common in intermediate (12.1%) and late-diagnosed asthma (36.2%) versus without asthma (10.4%) (both P <.001). Conclusions: Nonrespiratory diseases were more common in adults with asthma than in adults without asthma. The type of nonrespiratory diseases differed, and their frequency increased by increasing age at asthma diagnosis.
KW - Age of onset
KW - Asthma
KW - Chronic diseases
KW - Comorbidity
KW - Diabetes
KW - Hypertension
KW - Obesity
KW - Osteoporosis
KW - Population Study
KW - Sleep apnea
U2 - 10.1016/j.jaip.2022.10.024
DO - 10.1016/j.jaip.2022.10.024
M3 - Article
AN - SCOPUS:85142670904
SN - 2213-2198
VL - 11
SP - 555-563.e4
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
IS - 2
ER -
