Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium

Joel Nuotio; Tomi T. Laitinen; Alan R. Sinaiko; Jessica G. Woo; Elaine M. Urbina; David R. Jacobs; Julia Steinberger; Ronald J. Prineas; Matthew A. Sabin; David P. Burgner; Heikki Minn; Trudy L. Burns; Lydia A. Bazzano; Alison J. Venn; Jorma S.A. Viikari; Nina Hutri-Kähönen; Stephen R. Daniels; Olli T. Raitakari; Costan G. Magnussen; Markus Juonala; Terence Dwyer

doi:10.1038/s41366-021-01000-3

Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium

Joel Nuotio^*
, Tomi T. Laitinen
, Alan R. Sinaiko
, Jessica G. Woo
, Elaine M. Urbina
, David R. Jacobs
, Julia Steinberger
, Ronald J. Prineas
, Matthew A. Sabin
, David P. Burgner
, Heikki Minn
, Trudy L. Burns
, Lydia A. Bazzano
, Alison J. Venn
, Jorma S.A. Viikari
, Nina Hutri-Kähönen
, Stephen R. Daniels
, Olli T. Raitakari
, Costan G. Magnussen
, Markus Juonala

Terence Dwyer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

24 Citations (Scopus)

13 Downloads (Pure)

Abstract

Background: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce. Methods: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3–19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries. Results: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03–1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01–1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03–1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12–1.63). Conclusions: Higher childhood BMI was independently associated with increased overall cancer mortality.

Original language	English
Pages (from-to)	393-399
Journal	International Journal of Obesity
Volume	46
Early online date	2 Nov 2021
DOIs	https://doi.org/10.1038/s41366-021-01000-3
Publication status	Published - 2022
Publication type	A1 Journal article-refereed

Funding

This work was supported by the National Institutes of Health (NIH; Grant No.: R01 HL121230). Harmonization and other data work before obtaining NIH funding were supported by the Australian National Health and Medical Research Council Project (Grant Nos.: APP1098369, APP211316), the Academy of Finland (Grant No.: 126925, 121584, 124282, 129378, 117787, and 41071), the Social Insurance Institution of Finland; Kuopio, Tampere, and Turku University Hospital Medical Funds, Juho Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research, Finnish Cultural Foundation, Sigrid Juselius Foundation, and Yrjö Jahnsson Foundation. The funders of this study had no role in the design and conduct of the study. Open Access funding provided by University of Turku (UTU) including Turku University Central Hospital.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Publication forum classification

Publication forum level 3

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

Access to Document

10.1038/s41366-021-01000-3

s41366-021-01000-3Final published version, 789 KBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202111158418Licence: CC BY

Cite this

Nuotio, J., Laitinen, T. T., Sinaiko, A. R., Woo, J. G., Urbina, E. M., Jacobs, D. R., Steinberger, J., Prineas, R. J., Sabin, M. A., Burgner, D. P., Minn, H., Burns, T. L., Bazzano, L. A., Venn, A. J., Viikari, J. S. A., Hutri-Kähönen, N., Daniels, S. R., Raitakari, O. T., Magnussen, C. G., ... Dwyer, T. (2022). Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium. International Journal of Obesity, 46, 393-399. https://doi.org/10.1038/s41366-021-01000-3

@article{b425a3f4c3eb4df091bf4f44bd03acb3,

title = "Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium",

abstract = "Background: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce. Methods: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3–19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries. Results: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95\% confidence interval [CI] 1.03–1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95\%CI 1.01–1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95\%CI, 1.03–1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95\%CI 1.12–1.63). Conclusions: Higher childhood BMI was independently associated with increased overall cancer mortality.",

author = "Joel Nuotio and Laitinen, \{Tomi T.\} and Sinaiko, \{Alan R.\} and Woo, \{Jessica G.\} and Urbina, \{Elaine M.\} and Jacobs, \{David R.\} and Julia Steinberger and Prineas, \{Ronald J.\} and Sabin, \{Matthew A.\} and Burgner, \{David P.\} and Heikki Minn and Burns, \{Trudy L.\} and Bazzano, \{Lydia A.\} and Venn, \{Alison J.\} and Viikari, \{Jorma S.A.\} and Nina Hutri-K{\"a}h{\"o}nen and Daniels, \{Stephen R.\} and Raitakari, \{Olli T.\} and Magnussen, \{Costan G.\} and Markus Juonala and Terence Dwyer",

note = "Funding Information: This work was supported by the National Institutes of Health (NIH; Grant No.: R01 HL121230). Harmonization and other data work before obtaining NIH funding were supported by the Australian National Health and Medical Research Council Project (Grant Nos.: APP1098369, APP211316), the Academy of Finland (Grant No.: 126925, 121584, 124282, 129378, 117787, and 41071), the Social Insurance Institution of Finland; Kuopio, Tampere, and Turku University Hospital Medical Funds, Juho Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research, Finnish Cultural Foundation, Sigrid Juselius Foundation, and Yrj{\"o} Jahnsson Foundation. The funders of this study had no role in the design and conduct of the study. Open Access funding provided by University of Turku (UTU) including Turku University Central Hospital. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2022",

doi = "10.1038/s41366-021-01000-3",

language = "English",

volume = "46",

pages = "393--399",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "Springer Nature",

}

Nuotio, J, Laitinen, TT, Sinaiko, AR, Woo, JG, Urbina, EM, Jacobs, DR, Steinberger, J, Prineas, RJ, Sabin, MA, Burgner, DP, Minn, H, Burns, TL, Bazzano, LA, Venn, AJ, Viikari, JSA, Hutri-Kähönen, N, Daniels, SR, Raitakari, OT, Magnussen, CG, Juonala, M & Dwyer, T 2022, 'Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium', International Journal of Obesity, vol. 46, pp. 393-399. https://doi.org/10.1038/s41366-021-01000-3

TY - JOUR

T1 - Obesity during childhood is associated with higher cancer mortality rate during adulthood

T2 - the i3C Consortium

AU - Nuotio, Joel

AU - Laitinen, Tomi T.

AU - Sinaiko, Alan R.

AU - Woo, Jessica G.

AU - Urbina, Elaine M.

AU - Jacobs, David R.

AU - Steinberger, Julia

AU - Prineas, Ronald J.

AU - Sabin, Matthew A.

AU - Burgner, David P.

AU - Minn, Heikki

AU - Burns, Trudy L.

AU - Bazzano, Lydia A.

AU - Venn, Alison J.

AU - Viikari, Jorma S.A.

AU - Hutri-Kähönen, Nina

AU - Daniels, Stephen R.

AU - Raitakari, Olli T.

AU - Magnussen, Costan G.

AU - Juonala, Markus

AU - Dwyer, Terence

N1 - Funding Information: This work was supported by the National Institutes of Health (NIH; Grant No.: R01 HL121230). Harmonization and other data work before obtaining NIH funding were supported by the Australian National Health and Medical Research Council Project (Grant Nos.: APP1098369, APP211316), the Academy of Finland (Grant No.: 126925, 121584, 124282, 129378, 117787, and 41071), the Social Insurance Institution of Finland; Kuopio, Tampere, and Turku University Hospital Medical Funds, Juho Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research, Finnish Cultural Foundation, Sigrid Juselius Foundation, and Yrjö Jahnsson Foundation. The funders of this study had no role in the design and conduct of the study. Open Access funding provided by University of Turku (UTU) including Turku University Central Hospital. Publisher Copyright: © 2021, The Author(s).

PY - 2022

Y1 - 2022

N2 - Background: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce. Methods: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3–19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries. Results: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03–1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01–1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03–1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12–1.63). Conclusions: Higher childhood BMI was independently associated with increased overall cancer mortality.

AB - Background: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce. Methods: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3–19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries. Results: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03–1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01–1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03–1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12–1.63). Conclusions: Higher childhood BMI was independently associated with increased overall cancer mortality.

U2 - 10.1038/s41366-021-01000-3

DO - 10.1038/s41366-021-01000-3

M3 - Article

AN - SCOPUS:85118425051

SN - 0307-0565

VL - 46

SP - 393

EP - 399

JO - International Journal of Obesity

JF - International Journal of Obesity

ER -

Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium

Abstract

Funding

UN SDGs

Publication forum classification

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this