TY - JOUR
T1 - Occupational noise exposure and vestibular schwannoma
T2 - A case-control study in Sweden
AU - Aarhus, Lisa
AU - Kjærheim, Kristina
AU - Heikkinen, Sanna
AU - Martinsen, Jan Ivar
AU - Pukkala, Eero
AU - Selander, Jenny
AU - Sjöström, Mattias
AU - Skare, Øivind
AU - Straif, Kurt
AU - Mehlum, Ingrid Sivesind
N1 - Funding Information:
We thank the Nordic Cancer Union for funding of the Nordic Occupational Cancer Study (NOCCA) project. Conflict of interest: none declared.
Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11
Y1 - 2020/11
N2 - It has been suggested that the association between self-reported occupational noise exposure and vestibular schwannoma (VS), found in several studies, represents recall bias. Therefore, we aimed to study the relationship in a large case-control study using occupational noise measurements. We performed a case-control study using data from Sweden for 1,913 VS cases diagnosed in 1961-2009 and 9,566 age- and sex-matched population controls. We defined occupational history by linkage to national censuses from 1960, 1970, 1980, and 1990. We estimated occupational noise exposure for each case and control using a job-exposure matrix. There was no association between occupational noise exposure and VS. Among subjects assessed as ever exposed to occupational noise levels of ≥85 dB (214 cases and 1,142 controls), the odds ratio for VS per 5 years of exposure was 1.02 (95% confidence interval: 0.90, 1.17). Workers with noise levels of ≥85 dB for at least 15 years (5-year latency period), showed no increased risk of VS (odds ratio = 0.98, 95% confidence interval: 0.73, 1.31) compared with those who had never been exposed to noise levels of 75 dB or higher. In summary, our large study does not support an association between occupational noise exposure and VS.
AB - It has been suggested that the association between self-reported occupational noise exposure and vestibular schwannoma (VS), found in several studies, represents recall bias. Therefore, we aimed to study the relationship in a large case-control study using occupational noise measurements. We performed a case-control study using data from Sweden for 1,913 VS cases diagnosed in 1961-2009 and 9,566 age- and sex-matched population controls. We defined occupational history by linkage to national censuses from 1960, 1970, 1980, and 1990. We estimated occupational noise exposure for each case and control using a job-exposure matrix. There was no association between occupational noise exposure and VS. Among subjects assessed as ever exposed to occupational noise levels of ≥85 dB (214 cases and 1,142 controls), the odds ratio for VS per 5 years of exposure was 1.02 (95% confidence interval: 0.90, 1.17). Workers with noise levels of ≥85 dB for at least 15 years (5-year latency period), showed no increased risk of VS (odds ratio = 0.98, 95% confidence interval: 0.73, 1.31) compared with those who had never been exposed to noise levels of 75 dB or higher. In summary, our large study does not support an association between occupational noise exposure and VS.
KW - Case-control study
KW - Job-exposure matrix
KW - NOCCA
KW - Occupational noise
KW - Vestibular schwannoma
U2 - 10.1093/aje/kwaa091
DO - 10.1093/aje/kwaa091
M3 - Article
C2 - 32440685
AN - SCOPUS:85094983111
VL - 189
SP - 1342
EP - 1347
IS - 11
ER -
