Opium use and risk of lung cancer: A multicenter case-control study in Iran

Hamideh Rashidian; Maryam Hadji; Mahin Gholipour; Ahmad Naghibzadeh-Tahami; Maryam Marzban; Elham Mohebbi; Roya Safari-Faramani; Mahdieh Bakhshi; Monireh Sadat Seyyedsalehi; Bayan Hosseini; Reza Alizadeh-Navaei; Habib Emami; Ali Akbar Haghdoost; Abbas Rezaianzadeh; Abdolvahab Moradi; Alireza Ansari-Moghaddam; Azim Nejatizadeh; Soodabeh ShahidSales; Alireza Rezvani; Mohammad Hasan Larizadeh; Farid Najafi; Hossein Poustchi; Mohammad Ali Mohagheghi; Paul Brennan; Elisabete Weiderpass; Joachim Schüz; Eero Pukkala; Neal D. Freedman; Paolo Boffetta; Reza Malekzadeh; Arash Etemadi; Afarin Rahimi-Movaghar; Farin Kamangar; Kazem Zendehdel

doi:10.1002/ijc.34244

Opium use and risk of lung cancer: A multicenter case-control study in Iran

Hamideh Rashidian
, Maryam Hadji
, Mahin Gholipour
, Ahmad Naghibzadeh-Tahami
, Maryam Marzban
, Elham Mohebbi
, Roya Safari-Faramani
, Mahdieh Bakhshi
, Monireh Sadat Seyyedsalehi
, Bayan Hosseini
, Reza Alizadeh-Navaei
, Habib Emami
, Ali Akbar Haghdoost
, Abbas Rezaianzadeh
, Abdolvahab Moradi
, Alireza Ansari-Moghaddam
, Azim Nejatizadeh
, Soodabeh ShahidSales
, Alireza Rezvani
, Mohammad Hasan Larizadeh

Farid Najafi, Hossein Poustchi, Mohammad Ali Mohagheghi, Paul Brennan, Elisabete Weiderpass, Joachim Schüz, Eero Pukkala, Neal D. Freedman, Paolo Boffetta, Reza Malekzadeh, Arash Etemadi, Afarin Rahimi-Movaghar, Farin Kamangar, Kazem Zendehdel^*

^*Corresponding author for this work

Health Sciences

Research output: Contribution to journal › Article › Scientific › peer-review

11 Citations (Scopus)

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Abstract

Opium use was recently classified as a human carcinogen for lung cancer by the International Agency for Research on Cancer. We conducted a large, multicenter case-control study evaluating the association between opium use and the risk of lung cancer. We recruited 627 cases and 3477 controls from May 2017 to July 2020. We used unconditional logistic regression analyses to estimate the odds ratios (OR) and 95% confidence intervals (CI) and measured the association between opium use and the risk of lung cancer. The ORs were adjusted for the residential place, age, gender, socioeconomic status, cigarettes, and water pipe smoking. We found a 3.6-fold risk of lung cancer for regular opium users compared to never users (95% CI: 2.9, 4.6). There was a strong dose-response association between a cumulative count of opium use and lung cancer risk. The OR for regular opium use was higher for small cell carcinoma than in other histology (8.3, 95% CI: 4.8, 14.4). The OR of developing lung cancer among opium users was higher in females (7.4, 95% CI: 3.8, 14.5) than in males (3.3, 95% CI: 2.6, 4.2). The OR for users of both opium and tobacco was 13.4 (95% CI: 10.2, 17.7) compared to nonusers of anything. The risk of developing lung cancer is higher in regular opium users, and these results strengthen the conclusions on the carcinogenicity of opium. The association is stronger for small cell carcinoma cases than in other histology.

Original language	English
Pages (from-to)	203-213
Number of pages	11
Journal	International Journal of Cancer
Volume	152
Issue number	2
Early online date	13 Aug 2022
DOIs	https://doi.org/10.1002/ijc.34244
Publication status	Published - 15 Jan 2023
Publication type	A1 Journal article-refereed

Funding

Our study was funded by the National Institute for Medical Research Development (NIMAD), Iran (Grant number: 940045) and partially supported by Investigator Grant No. 24706 of Fondazione AIRC, Italy. We thank our collaborators, especially the interviewers from all 10 study centers that performed data collection carefully and provided us with high‐quality information. We thank Mrs. Vahideh Peyghambari and Elmira Ebrahimi for the biobank management.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adenocarcinoma
Iran
lung cancer
opiate
opium
small cell
squamous cell

Publication forum classification

Publication forum level 2

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/ijc.34244

Opium Use and Risk of Lung Cancer
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Rashidian, H., Hadji, M., Gholipour, M., Naghibzadeh-Tahami, A., Marzban, M., Mohebbi, E., Safari-Faramani, R., Bakhshi, M., Sadat Seyyedsalehi, M., Hosseini, B., Alizadeh-Navaei, R., Emami, H., Haghdoost, A. A., Rezaianzadeh, A., Moradi, A., Ansari-Moghaddam, A., Nejatizadeh, A., ShahidSales, S., Rezvani, A., ... Zendehdel, K. (2023). Opium use and risk of lung cancer: A multicenter case-control study in Iran. International Journal of Cancer, 152(2), 203-213. https://doi.org/10.1002/ijc.34244

@article{057325f514bb45389c3da569df7db485,

title = "Opium use and risk of lung cancer: A multicenter case-control study in Iran",

abstract = "Opium use was recently classified as a human carcinogen for lung cancer by the International Agency for Research on Cancer. We conducted a large, multicenter case-control study evaluating the association between opium use and the risk of lung cancer. We recruited 627 cases and 3477 controls from May 2017 to July 2020. We used unconditional logistic regression analyses to estimate the odds ratios (OR) and 95\% confidence intervals (CI) and measured the association between opium use and the risk of lung cancer. The ORs were adjusted for the residential place, age, gender, socioeconomic status, cigarettes, and water pipe smoking. We found a 3.6-fold risk of lung cancer for regular opium users compared to never users (95\% CI: 2.9, 4.6). There was a strong dose-response association between a cumulative count of opium use and lung cancer risk. The OR for regular opium use was higher for small cell carcinoma than in other histology (8.3, 95\% CI: 4.8, 14.4). The OR of developing lung cancer among opium users was higher in females (7.4, 95\% CI: 3.8, 14.5) than in males (3.3, 95\% CI: 2.6, 4.2). The OR for users of both opium and tobacco was 13.4 (95\% CI: 10.2, 17.7) compared to nonusers of anything. The risk of developing lung cancer is higher in regular opium users, and these results strengthen the conclusions on the carcinogenicity of opium. The association is stronger for small cell carcinoma cases than in other histology.",

keywords = "adenocarcinoma, Iran, lung cancer, opiate, opium, small cell, squamous cell",

author = "Hamideh Rashidian and Maryam Hadji and Mahin Gholipour and Ahmad Naghibzadeh-Tahami and Maryam Marzban and Elham Mohebbi and Roya Safari-Faramani and Mahdieh Bakhshi and \{Sadat Seyyedsalehi\}, Monireh and Bayan Hosseini and Reza Alizadeh-Navaei and Habib Emami and Haghdoost, \{Ali Akbar\} and Abbas Rezaianzadeh and Abdolvahab Moradi and Alireza Ansari-Moghaddam and Azim Nejatizadeh and Soodabeh ShahidSales and Alireza Rezvani and Larizadeh, \{Mohammad Hasan\} and Farid Najafi and Hossein Poustchi and Mohagheghi, \{Mohammad Ali\} and Paul Brennan and Elisabete Weiderpass and Joachim Sch{\"u}z and Eero Pukkala and Freedman, \{Neal D.\} and Paolo Boffetta and Reza Malekzadeh and Arash Etemadi and Afarin Rahimi-Movaghar and Farin Kamangar and Kazem Zendehdel",

note = "Funding Information: Our study was funded by the National Institute for Medical Research Development (NIMAD), Iran (Grant number: 940045) and partially supported by Investigator Grant No. 24706 of Fondazione AIRC, Italy. We thank our collaborators, especially the interviewers from all 10 study centers that performed data collection carefully and provided us with high‐quality information. We thank Mrs. Vahideh Peyghambari and Elmira Ebrahimi for the biobank management. Publisher Copyright: {\textcopyright} 2022 UICC.",

year = "2023",

month = jan,

day = "15",

doi = "10.1002/ijc.34244",

language = "English",

volume = "152",

pages = "203--213",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley and Sons Inc",

number = "2",

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Rashidian, H, Hadji, M, Gholipour, M, Naghibzadeh-Tahami, A, Marzban, M, Mohebbi, E, Safari-Faramani, R, Bakhshi, M, Sadat Seyyedsalehi, M, Hosseini, B, Alizadeh-Navaei, R, Emami, H, Haghdoost, AA, Rezaianzadeh, A, Moradi, A, Ansari-Moghaddam, A, Nejatizadeh, A, ShahidSales, S, Rezvani, A, Larizadeh, MH, Najafi, F, Poustchi, H, Mohagheghi, MA, Brennan, P, Weiderpass, E, Schüz, J, Pukkala, E, Freedman, ND, Boffetta, P, Malekzadeh, R, Etemadi, A, Rahimi-Movaghar, A, Kamangar, F & Zendehdel, K 2023, 'Opium use and risk of lung cancer: A multicenter case-control study in Iran', International Journal of Cancer, vol. 152, no. 2, pp. 203-213. https://doi.org/10.1002/ijc.34244

TY - JOUR

T1 - Opium use and risk of lung cancer

T2 - A multicenter case-control study in Iran

AU - Rashidian, Hamideh

AU - Hadji, Maryam

AU - Gholipour, Mahin

AU - Naghibzadeh-Tahami, Ahmad

AU - Marzban, Maryam

AU - Mohebbi, Elham

AU - Safari-Faramani, Roya

AU - Bakhshi, Mahdieh

AU - Sadat Seyyedsalehi, Monireh

AU - Hosseini, Bayan

AU - Alizadeh-Navaei, Reza

AU - Emami, Habib

AU - Haghdoost, Ali Akbar

AU - Rezaianzadeh, Abbas

AU - Moradi, Abdolvahab

AU - Ansari-Moghaddam, Alireza

AU - Nejatizadeh, Azim

AU - ShahidSales, Soodabeh

AU - Rezvani, Alireza

AU - Larizadeh, Mohammad Hasan

AU - Najafi, Farid

AU - Poustchi, Hossein

AU - Mohagheghi, Mohammad Ali

AU - Brennan, Paul

AU - Weiderpass, Elisabete

AU - Schüz, Joachim

AU - Pukkala, Eero

AU - Freedman, Neal D.

AU - Boffetta, Paolo

AU - Malekzadeh, Reza

AU - Etemadi, Arash

AU - Rahimi-Movaghar, Afarin

AU - Kamangar, Farin

AU - Zendehdel, Kazem

N1 - Funding Information: Our study was funded by the National Institute for Medical Research Development (NIMAD), Iran (Grant number: 940045) and partially supported by Investigator Grant No. 24706 of Fondazione AIRC, Italy. We thank our collaborators, especially the interviewers from all 10 study centers that performed data collection carefully and provided us with high‐quality information. We thank Mrs. Vahideh Peyghambari and Elmira Ebrahimi for the biobank management. Publisher Copyright: © 2022 UICC.

PY - 2023/1/15

Y1 - 2023/1/15

N2 - Opium use was recently classified as a human carcinogen for lung cancer by the International Agency for Research on Cancer. We conducted a large, multicenter case-control study evaluating the association between opium use and the risk of lung cancer. We recruited 627 cases and 3477 controls from May 2017 to July 2020. We used unconditional logistic regression analyses to estimate the odds ratios (OR) and 95% confidence intervals (CI) and measured the association between opium use and the risk of lung cancer. The ORs were adjusted for the residential place, age, gender, socioeconomic status, cigarettes, and water pipe smoking. We found a 3.6-fold risk of lung cancer for regular opium users compared to never users (95% CI: 2.9, 4.6). There was a strong dose-response association between a cumulative count of opium use and lung cancer risk. The OR for regular opium use was higher for small cell carcinoma than in other histology (8.3, 95% CI: 4.8, 14.4). The OR of developing lung cancer among opium users was higher in females (7.4, 95% CI: 3.8, 14.5) than in males (3.3, 95% CI: 2.6, 4.2). The OR for users of both opium and tobacco was 13.4 (95% CI: 10.2, 17.7) compared to nonusers of anything. The risk of developing lung cancer is higher in regular opium users, and these results strengthen the conclusions on the carcinogenicity of opium. The association is stronger for small cell carcinoma cases than in other histology.

AB - Opium use was recently classified as a human carcinogen for lung cancer by the International Agency for Research on Cancer. We conducted a large, multicenter case-control study evaluating the association between opium use and the risk of lung cancer. We recruited 627 cases and 3477 controls from May 2017 to July 2020. We used unconditional logistic regression analyses to estimate the odds ratios (OR) and 95% confidence intervals (CI) and measured the association between opium use and the risk of lung cancer. The ORs were adjusted for the residential place, age, gender, socioeconomic status, cigarettes, and water pipe smoking. We found a 3.6-fold risk of lung cancer for regular opium users compared to never users (95% CI: 2.9, 4.6). There was a strong dose-response association between a cumulative count of opium use and lung cancer risk. The OR for regular opium use was higher for small cell carcinoma than in other histology (8.3, 95% CI: 4.8, 14.4). The OR of developing lung cancer among opium users was higher in females (7.4, 95% CI: 3.8, 14.5) than in males (3.3, 95% CI: 2.6, 4.2). The OR for users of both opium and tobacco was 13.4 (95% CI: 10.2, 17.7) compared to nonusers of anything. The risk of developing lung cancer is higher in regular opium users, and these results strengthen the conclusions on the carcinogenicity of opium. The association is stronger for small cell carcinoma cases than in other histology.

KW - adenocarcinoma

KW - Iran

KW - lung cancer

KW - opiate

KW - opium

KW - small cell

KW - squamous cell

U2 - 10.1002/ijc.34244

DO - 10.1002/ijc.34244

M3 - Article

C2 - 36043555

AN - SCOPUS:85137325965

SN - 0020-7136

VL - 152

SP - 203

EP - 213

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 2

ER -

Opium use and risk of lung cancer: A multicenter case-control study in Iran

Abstract

Funding

UN SDGs

Keywords

Publication forum classification

ASJC Scopus subject areas

Access to Document

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