Photodynamic self–disinfecting surface using pyridinium phthalocyanine

Lijo George, Alexander Müller, Beate Röder, Ville Santala, Alexander Efimov

    Research output: Contribution to journalArticleScientificpeer-review

    9 Citations (Scopus)

    Abstract

    We have synthesized novel phthalocyanine with four pyridyl substituents connected to α-phthalo-positions via direct C-C bond. The Zn complex and tetracationic derivatives of phthalocyanine were also synthesized and the dyes were impregnated into filter paper to prepare photoactive antimicrobial surface. The photodynamic antimicrobial efficacy of the dyed paper samples was evaluated by a simple and fast setup using bioluminescent microbes. Escherichia coli and Acinetobacter baylyi ADP1 strains carrying bacterial luciferase genes were used in the screening experiment. The most efficient compound, tetracationic zinc derivative 8, was investigated further. The compound was highly water soluble, had high molar absorptivity and exhibited good adhesion to the filter paper without leaching into the solution. The singlet oxygen quantum yield of tetracationic zinc derivative 8 in water was found out to be 30 ± 20%. According to the cell viability assay test performed on E. coli wild type in solution, the molecule had similar or better photo toxicity as the reference photosensitizer, tetrakis (1-methyl-pyridinium-4-yl)porphyrin (TMPyP). Antimicrobial efficacy of the dye 8 on photoactive surface was studied by live cell assessment through colony forming unit (CFU) counting. The colored surface demonstrated 3 log reduction in CFU against E. coli and A. baylyi ADP1 just after 1 h of illumination with the white light of low intensity.

    Original languageEnglish
    Pages (from-to)334-342
    Number of pages9
    JournalDyes and Pigments
    Volume147
    DOIs
    Publication statusPublished - 1 Dec 2017
    Publication typeA1 Journal article-refereed

    Keywords

    • Antimicrobial
    • Photodynamic antimicrobial chemotherapy
    • Pyridinium phthalocyanine
    • Self-disinfecting surface
    • Singlet oxygen

    Publication forum classification

    • Publication forum level 2

    ASJC Scopus subject areas

    • Chemical Engineering(all)
    • Process Chemistry and Technology

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