Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy

Sini Korpelainen; Sari Hämäläinen; Matti Vänskä; Irma Koivula; Kari Pulkki; Esa Jantunen; Auni Juutilainen; Anna Kaisa Purhonen

doi:10.1016/j.cyto.2020.155021

Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy

Sini Korpelainen
, Sari Hämäläinen
, Matti Vänskä
, Irma Koivula
, Kari Pulkki
, Esa Jantunen
, Auni Juutilainen
, Anna Kaisa Purhonen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0–3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN in the subgroup of autologous stem cell transplant recipients with non-Hodgkin lymphoma.

Original language	English
Article number	155021
Journal	Cytokine
Volume	129
DOIs	https://doi.org/10.1016/j.cyto.2020.155021
Publication status	Published - 2020
Publication type	A1 Journal article-refereed

Funding

We are grateful to Ms Raija Isom?ki and Ms Tiina Mets?vainio for technical assistance.

Keywords

Acute myeloid leukemia
Febrile neutropenia
Interleukin-18
Multiple myeloma
Non-Hodgkin lymphoma

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Hematology
Molecular Biology

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10.1016/j.cyto.2020.155021

Cite this

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title = "Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy",

abstract = "In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0–3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN in the subgroup of autologous stem cell transplant recipients with non-Hodgkin lymphoma.",

keywords = "Acute myeloid leukemia, Febrile neutropenia, Interleukin-18, Multiple myeloma, Non-Hodgkin lymphoma",

author = "Sini Korpelainen and Sari H{\"a}m{\"a}l{\"a}inen and Matti V{\"a}nsk{\"a} and Irma Koivula and Kari Pulkki and Esa Jantunen and Auni Juutilainen and Purhonen, \{Anna Kaisa\}",

note = "Funding Information: We are grateful to Ms Raija Isom?ki and Ms Tiina Mets?vainio for technical assistance. Publisher Copyright: {\textcopyright} 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

doi = "10.1016/j.cyto.2020.155021",

language = "English",

volume = "129",

journal = "Cytokine",

issn = "1043-4666",

publisher = "Academic Press",

}

TY - JOUR

T1 - Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy

AU - Korpelainen, Sini

AU - Hämäläinen, Sari

AU - Vänskä, Matti

AU - Koivula, Irma

AU - Pulkki, Kari

AU - Jantunen, Esa

AU - Juutilainen, Auni

AU - Purhonen, Anna Kaisa

N1 - Funding Information: We are grateful to Ms Raija Isom?ki and Ms Tiina Mets?vainio for technical assistance. Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0–3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN in the subgroup of autologous stem cell transplant recipients with non-Hodgkin lymphoma.

AB - In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0–3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN in the subgroup of autologous stem cell transplant recipients with non-Hodgkin lymphoma.

KW - Acute myeloid leukemia

KW - Febrile neutropenia

KW - Interleukin-18

KW - Multiple myeloma

KW - Non-Hodgkin lymphoma

U2 - 10.1016/j.cyto.2020.155021

DO - 10.1016/j.cyto.2020.155021

M3 - Article

C2 - 32087594

AN - SCOPUS:85079527533

SN - 1043-4666

VL - 129

JO - Cytokine

JF - Cytokine

M1 - 155021

ER -

Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy

Abstract

Funding

Keywords

Publication forum classification

ASJC Scopus subject areas

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