Platelet count is not associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as defined by the 2010 consensus definition

Essi Raatikainen, Heikki Kiiski, Anne Kuitunen, Eija Junttila, Heini Huhtala, Antti Ronkainen, Liisa Pyysalo, Annukka Vahtera

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Abstract

Background: Although delayed cerebral ischemia (DCI) commonly complicates recovery in survivors of aneurysmal subarachnoid hemorrhage (aSAH), its pathophysiology is incompletely understood. Previous studies examining the association of DCI and platelet count have demonstrated contradictory results. This study aimed to investigate this association in a cohort of aSAH patients using the 2010 consensus definition of DCI. Methods: We conducted a retrospective single-center observational study of consecutive adult aSAH patients admitted to the intensive care unit from January 2010 to December 2014. Platelet count and DCI evaluations were performed daily in the first 14 days after admission. DCI was defined according to the 2010 consensus criteria. Results: A total of 340 patients were included for analysis. DCI incidence was 37.1%. Platelet count was not significantly associated with occurrence of DCI on any day. Mean platelet count was lowest on day 3 after aSAH and then increased to exceed the count at admission on day 6. Treatment modality and use of dual antiplatelet therapy were not associated with DCI. Conclusions: Platelet count was not associated with DCI as defined by the 2010 consensus criteria. Future studies adhering to the 2010 consensus definition of DCI are needed to clarify the role of platelets and platelet function in DCI pathophysiology.

Original languageEnglish
Article number120227
Number of pages6
JournalJournal of the Neurological Sciences
Volume436
DOIs
Publication statusPublished - 15 May 2022
Publication typeA1 Journal article-refereed

Keywords

  • Aneurysmal subarachnoid hemorrhage
  • Delayed cerebral ischemia
  • Intensive care unit
  • Platelet

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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