Poststroke dementia is associated with recurrent ischaemic stroke

Gerli Sibolt; Sami Curtze; Susanna Melkas; Jukka Putaala; Tarja Pohjasvaara; Markku Kaste; Pekka J. Karhunen; Niku K J Oksala; Timo Erkinjuntti

doi:10.1136/jnnp-2012-304084

Poststroke dementia is associated with recurrent ischaemic stroke

Gerli Sibolt
, Sami Curtze
, Susanna Melkas
, Jukka Putaala
, Tarja Pohjasvaara
, Markku Kaste
, Pekka J. Karhunen
, Niku K J Oksala
, Timo Erkinjuntti

Department of Clinical Chemistry

Research output: Contribution to journal › Article › Scientific › peer-review

47 Citations (Scopus)

Abstract

Objective: To investigate whether poststroke dementia (PSD) diagnosed after ischaemic stroke predicts recurrent ischaemic stroke in long-term follow-up. Methods: We included 486 consecutive patients with ischaemic stroke (388 with first-ever stroke) admitted to Helsinki University Central Hospital who were followed-up for 12 years. Dementia was diagnosed in 115 patients using the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III) criteria. The effects of risk factors and PSD on survival free of recurrent stroke were estimated using Kaplan-Meier log-rank analyses, and the HRs for stroke recurrence were calculated using Cox proportional hazards models. Results: In the entire cohort, patients with PSD had a shorter mean time to recurrent stroke (7.13 years, 95% CI 6.20 to 8.06) than patients without dementia (9.41 years, 8.89 to 9.92: log rank p

Original language	English
Pages (from-to)	722-726
Number of pages	5
Journal	JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Volume	84
Issue number	7
DOIs	https://doi.org/10.1136/jnnp-2012-304084
Publication status	Published - 2013
Publication type	A1 Journal article-refereed

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10.1136/jnnp-2012-304084

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title = "Poststroke dementia is associated with recurrent ischaemic stroke",

abstract = "Objective: To investigate whether poststroke dementia (PSD) diagnosed after ischaemic stroke predicts recurrent ischaemic stroke in long-term follow-up. Methods: We included 486 consecutive patients with ischaemic stroke (388 with first-ever stroke) admitted to Helsinki University Central Hospital who were followed-up for 12 years. Dementia was diagnosed in 115 patients using the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III) criteria. The effects of risk factors and PSD on survival free of recurrent stroke were estimated using Kaplan-Meier log-rank analyses, and the HRs for stroke recurrence were calculated using Cox proportional hazards models. Results: In the entire cohort, patients with PSD had a shorter mean time to recurrent stroke (7.13 years, 95\% CI 6.20 to 8.06) than patients without dementia (9.41 years, 8.89 to 9.92: log rank p",

author = "Gerli Sibolt and Sami Curtze and Susanna Melkas and Jukka Putaala and Tarja Pohjasvaara and Markku Kaste and Karhunen, \{Pekka J.\} and Oksala, \{Niku K J\} and Timo Erkinjuntti",

year = "2013",

doi = "10.1136/jnnp-2012-304084",

language = "English",

volume = "84",

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T1 - Poststroke dementia is associated with recurrent ischaemic stroke

AU - Sibolt, Gerli

AU - Curtze, Sami

AU - Melkas, Susanna

AU - Putaala, Jukka

AU - Pohjasvaara, Tarja

AU - Kaste, Markku

AU - Karhunen, Pekka J.

AU - Oksala, Niku K J

AU - Erkinjuntti, Timo

PY - 2013

Y1 - 2013

N2 - Objective: To investigate whether poststroke dementia (PSD) diagnosed after ischaemic stroke predicts recurrent ischaemic stroke in long-term follow-up. Methods: We included 486 consecutive patients with ischaemic stroke (388 with first-ever stroke) admitted to Helsinki University Central Hospital who were followed-up for 12 years. Dementia was diagnosed in 115 patients using the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III) criteria. The effects of risk factors and PSD on survival free of recurrent stroke were estimated using Kaplan-Meier log-rank analyses, and the HRs for stroke recurrence were calculated using Cox proportional hazards models. Results: In the entire cohort, patients with PSD had a shorter mean time to recurrent stroke (7.13 years, 95% CI 6.20 to 8.06) than patients without dementia (9.41 years, 8.89 to 9.92: log rank p

AB - Objective: To investigate whether poststroke dementia (PSD) diagnosed after ischaemic stroke predicts recurrent ischaemic stroke in long-term follow-up. Methods: We included 486 consecutive patients with ischaemic stroke (388 with first-ever stroke) admitted to Helsinki University Central Hospital who were followed-up for 12 years. Dementia was diagnosed in 115 patients using the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III) criteria. The effects of risk factors and PSD on survival free of recurrent stroke were estimated using Kaplan-Meier log-rank analyses, and the HRs for stroke recurrence were calculated using Cox proportional hazards models. Results: In the entire cohort, patients with PSD had a shorter mean time to recurrent stroke (7.13 years, 95% CI 6.20 to 8.06) than patients without dementia (9.41 years, 8.89 to 9.92: log rank p

U2 - 10.1136/jnnp-2012-304084

DO - 10.1136/jnnp-2012-304084

M3 - Article

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SN - 0022-3050

VL - 84

SP - 722

EP - 726

JO - JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

JF - JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IS - 7

ER -

Poststroke dementia is associated with recurrent ischaemic stroke

Abstract

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