Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

Kate Bramham; Pia M Villa; Jennifer R Joslin; Hannele Laivuori; Esa Hämäläinen; Eero Kajantie; Katri Räikkönen; Anukatriina Pesonen; Paul Seed; R Neil Dalton; Charles Turner; Max Wong; Peter Von Dadelszen; James M Roberts; Lucilla Poston; Lucy C Chappell

doi:10.1080/10641955.2020.1769643

Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

Kate Bramham, Pia M Villa, Jennifer R Joslin, Hannele Laivuori, Esa Hämäläinen, Eero Kajantie, Katri Räikkönen, Anukatriina Pesonen, Paul Seed, R Neil Dalton, Charles Turner, Max Wong, Peter Von Dadelszen, James M Roberts, Lucilla Poston, Lucy C Chappell

Research output: Contribution to journal › Article › Scientific › peer-review

12 Citations (Scopus)

Abstract

OBJECTIVE: To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension.

METHODS: Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls.

RESULTS: Syndecan-1 concentrations were lower at 26-27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumin:creatinine ratio were also associated with development of superimposed preeclampsia.

CONCLUSION: Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.

Original language	English
Pages (from-to)	326-335
Number of pages	10
Journal	HYPERTENSION IN PREGNANCY
Volume	39
Issue number	3
DOIs	https://doi.org/10.1080/10641955.2020.1769643
Publication status	Published - 2020
Publication type	A1 Journal article-refereed

Keywords

Adult
Biomarkers
Cystatin C/blood
Female
Humans
Hypertension/blood
Lipocalin-2/blood
Longitudinal Studies
Placenta
Placenta Growth Factor/blood
Pre-Eclampsia/blood
Pregnancy
Prospective Studies
Vascular Endothelial Growth Factor Receptor-1/blood

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Publication forum level 1

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10.1080/10641955.2020.1769643

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Bramham, K., Villa, P. M., Joslin, J. R., Laivuori, H., Hämäläinen, E., Kajantie, E., Räikkönen, K., Pesonen, A., Seed, P., Dalton, R. N., Turner, C., Wong, M., Von Dadelszen, P., Roberts, J. M., Poston, L., & Chappell, L. C. (2020). Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort. HYPERTENSION IN PREGNANCY, 39(3), 326-335. https://doi.org/10.1080/10641955.2020.1769643

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title = "Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort",

abstract = "OBJECTIVE: To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension.METHODS: Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls.RESULTS: Syndecan-1 concentrations were lower at 26-27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumin:creatinine ratio were also associated with development of superimposed preeclampsia.CONCLUSION: Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.",

keywords = "Adult, Biomarkers, Cystatin C/blood, Female, Humans, Hypertension/blood, Lipocalin-2/blood, Longitudinal Studies, Placenta, Placenta Growth Factor/blood, Pre-Eclampsia/blood, Pregnancy, Prospective Studies, Vascular Endothelial Growth Factor Receptor-1/blood",

author = "Kate Bramham and Villa, {Pia M} and Joslin, {Jennifer R} and Hannele Laivuori and Esa H{\"a}m{\"a}l{\"a}inen and Eero Kajantie and Katri R{\"a}ikk{\"o}nen and Anukatriina Pesonen and Paul Seed and Dalton, {R Neil} and Charles Turner and Max Wong and {Von Dadelszen}, Peter and Roberts, {James M} and Lucilla Poston and Chappell, {Lucy C}",

year = "2020",

doi = "10.1080/10641955.2020.1769643",

language = "English",

volume = "39",

pages = "326--335",

journal = "HYPERTENSION IN PREGNANCY",

issn = "1064-1955",

publisher = "American School of Classical Studies at Athens",

number = "3",

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Bramham, K, Villa, PM, Joslin, JR, Laivuori, H, Hämäläinen, E, Kajantie, E, Räikkönen, K, Pesonen, A, Seed, P, Dalton, RN, Turner, C, Wong, M, Von Dadelszen, P, Roberts, JM, Poston, L & Chappell, LC 2020, 'Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort', HYPERTENSION IN PREGNANCY, vol. 39, no. 3, pp. 326-335. https://doi.org/10.1080/10641955.2020.1769643

Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort. / Bramham, Kate; Villa, Pia M; Joslin, Jennifer R et al.
In: HYPERTENSION IN PREGNANCY, Vol. 39, No. 3, 2020, p. 326-335.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Predisposition to superimposed preeclampsia in women with chronic hypertension

T2 - endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

AU - Bramham, Kate

AU - Villa, Pia M

AU - Joslin, Jennifer R

AU - Laivuori, Hannele

AU - Hämäläinen, Esa

AU - Kajantie, Eero

AU - Räikkönen, Katri

AU - Pesonen, Anukatriina

AU - Seed, Paul

AU - Dalton, R Neil

AU - Turner, Charles

AU - Wong, Max

AU - Von Dadelszen, Peter

AU - Roberts, James M

AU - Poston, Lucilla

AU - Chappell, Lucy C

PY - 2020

Y1 - 2020

N2 - OBJECTIVE: To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension.METHODS: Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls.RESULTS: Syndecan-1 concentrations were lower at 26-27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumin:creatinine ratio were also associated with development of superimposed preeclampsia.CONCLUSION: Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.

AB - OBJECTIVE: To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension.METHODS: Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls.RESULTS: Syndecan-1 concentrations were lower at 26-27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumin:creatinine ratio were also associated with development of superimposed preeclampsia.CONCLUSION: Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.

KW - Adult

KW - Biomarkers

KW - Cystatin C/blood

KW - Female

KW - Humans

KW - Hypertension/blood

KW - Lipocalin-2/blood

KW - Longitudinal Studies

KW - Placenta

KW - Placenta Growth Factor/blood

KW - Pre-Eclampsia/blood

KW - Pregnancy

KW - Prospective Studies

KW - Vascular Endothelial Growth Factor Receptor-1/blood

U2 - 10.1080/10641955.2020.1769643

DO - 10.1080/10641955.2020.1769643

M3 - Article

C2 - 32479208

SN - 1064-1955

VL - 39

SP - 326

EP - 335

JO - HYPERTENSION IN PREGNANCY

JF - HYPERTENSION IN PREGNANCY

IS - 3

ER -

Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

Abstract

Keywords

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