Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

Kate Bramham, Pia M Villa, Jennifer R Joslin, Hannele Laivuori, Esa Hämäläinen, Eero Kajantie, Katri Räikkönen, Anukatriina Pesonen, Paul Seed, R Neil Dalton, Charles Turner, Max Wong, Peter Von Dadelszen, James M Roberts, Lucilla Poston, Lucy C Chappell

Research output: Contribution to journalArticleScientificpeer-review

Abstract

OBJECTIVE: To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension.

METHODS: Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls.

RESULTS: Syndecan-1 concentrations were lower at 26-27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumin:creatinine ratio were also associated with development of superimposed preeclampsia.

CONCLUSION: Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.

Original languageEnglish
Pages (from-to)326-335
Number of pages10
JournalHYPERTENSION IN PREGNANCY
Volume39
Issue number3
DOIs
Publication statusPublished - 2020
Publication typeA1 Journal article-refereed

Keywords

  • Adult
  • Biomarkers
  • Cystatin C/blood
  • Female
  • Humans
  • Hypertension/blood
  • Lipocalin-2/blood
  • Longitudinal Studies
  • Placenta
  • Placenta Growth Factor/blood
  • Pre-Eclampsia/blood
  • Pregnancy
  • Prospective Studies
  • Vascular Endothelial Growth Factor Receptor-1/blood

Publication forum classification

  • Publication forum level 1

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