OBJECTIVE: To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension.
METHODS: Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls.
RESULTS: Syndecan-1 concentrations were lower at 26-27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumin:creatinine ratio were also associated with development of superimposed preeclampsia.
CONCLUSION: Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.
- Cystatin C/blood
- Longitudinal Studies
- Placenta Growth Factor/blood
- Prospective Studies
- Vascular Endothelial Growth Factor Receptor-1/blood
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