Predisposition to superimposed preeclampsia in women with chronic hypertension: endothelial, renal, cardiac, and placental factors in a prospective longitudinal cohort

Kate Bramham, Pia M Villa, Jennifer R Joslin, Hannele Laivuori, Esa Hämäläinen, Eero Kajantie, Katri Räikkönen, Anukatriina Pesonen, Paul Seed, R Neil Dalton, Charles Turner, Max Wong, Peter Von Dadelszen, James M Roberts, Lucilla Poston, Lucy C Chappell

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    OBJECTIVE: To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension.

    METHODS: Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls.

    RESULTS: Syndecan-1 concentrations were lower at 26-27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumin:creatinine ratio were also associated with development of superimposed preeclampsia.

    CONCLUSION: Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.

    Original languageEnglish
    Pages (from-to)326-335
    Number of pages10
    JournalHYPERTENSION IN PREGNANCY
    Volume39
    Issue number3
    DOIs
    Publication statusPublished - 2020
    Publication typeA1 Journal article-refereed

    Keywords

    • Adult
    • Biomarkers
    • Cystatin C/blood
    • Female
    • Humans
    • Hypertension/blood
    • Lipocalin-2/blood
    • Longitudinal Studies
    • Placenta
    • Placenta Growth Factor/blood
    • Pre-Eclampsia/blood
    • Pregnancy
    • Prospective Studies
    • Vascular Endothelial Growth Factor Receptor-1/blood

    Publication forum classification

    • Publication forum level 1

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