Prevention of Travellers Diarrhoea by Lactobacillus GG

P J Oksanen; S Salminen; M Saxelin; P Hämäläinen; A Ihantola-Vormisto; L Muurasniemi-Isoviita; S Nikkari; T Oksanen; I Pörsti; E Salminen; S Siitonen; H Stuckey; A Toppila; H Vapaatalo

doi:10.3109/07853899009147242

Prevention of Travellers Diarrhoea by Lactobacillus GG

P J Oksanen, S Salminen, M Saxelin, P Hämäläinen, A Ihantola-Vormisto, L Muurasniemi-Isoviita, S Nikkari, T Oksanen, I Pörsti, E Salminen, S Siitonen, H Stuckey, A Toppila, H Vapaatalo

Research output: Contribution to journal › Article › Scientific › peer-review

349 Citations (Scopus)

Abstract

A placebo-controlled double-blind study was conducted on the efficacy of Lactobacillus GG in preventing travellers' diarrhoea. Altogether 820 persons travelling on holiday to southern Turkey to two destinations were randomized into two groups receiving either Lactobacillus GG or placebo in identical sachets. On the return flight each participant completed a questionnaire indicating the incidence of diarrhoea and related symptoms during the trip. Of the original group 756 (92%) subjects completed the study acceptably. The overall incidence of diarrhoea was 43.8% (331 cases). The total incidence of diarrhoea in the placebo group was 46.5% and in the Lactobacillus GG 41.0% indicating an overall protection of 11.8%. Protection rates varied between two different destinations with the maximum protection rate reported as 39.5%. Among older age groups there was significantly less diarrhoea when compared to younger travellers. Lactobacillus GG appeared to be effective in reducing the occurrence of travellers' diarrhoea in one of the two destinations with no side effects.

Original language	English
Pages (from-to)	53-56
Number of pages	4
Journal	Annals of Medicine
Volume	22
Issue number	1
DOIs	https://doi.org/10.3109/07853899009147242
Publication status	Published - 1990
Externally published	Yes
Publication type	A1 Journal article-refereed

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Child
Diarrhea/prevention & control
Double-Blind Method
Female
Humans
Lactobacillus/physiology
Male
Middle Aged
Randomized Controlled Trials as Topic
Surveys and Questionnaires
Travel
Turkey

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Prevention of Travellers Diarrhoea by Lactobacillus GG",

abstract = "A placebo-controlled double-blind study was conducted on the efficacy of Lactobacillus GG in preventing travellers' diarrhoea. Altogether 820 persons travelling on holiday to southern Turkey to two destinations were randomized into two groups receiving either Lactobacillus GG or placebo in identical sachets. On the return flight each participant completed a questionnaire indicating the incidence of diarrhoea and related symptoms during the trip. Of the original group 756 (92%) subjects completed the study acceptably. The overall incidence of diarrhoea was 43.8% (331 cases). The total incidence of diarrhoea in the placebo group was 46.5% and in the Lactobacillus GG 41.0% indicating an overall protection of 11.8%. Protection rates varied between two different destinations with the maximum protection rate reported as 39.5%. Among older age groups there was significantly less diarrhoea when compared to younger travellers. Lactobacillus GG appeared to be effective in reducing the occurrence of travellers' diarrhoea in one of the two destinations with no side effects.",

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author = "Oksanen, {P J} and S Salminen and M Saxelin and P H{\"a}m{\"a}l{\"a}inen and A Ihantola-Vormisto and L Muurasniemi-Isoviita and S Nikkari and T Oksanen and I P{\"o}rsti and E Salminen and S Siitonen and H Stuckey and A Toppila and H Vapaatalo",

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language = "English",

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pages = "53--56",

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TY - JOUR

T1 - Prevention of Travellers Diarrhoea by Lactobacillus GG

AU - Oksanen, P J

AU - Salminen, S

AU - Saxelin, M

AU - Hämäläinen, P

AU - Ihantola-Vormisto, A

AU - Muurasniemi-Isoviita, L

AU - Nikkari, S

AU - Oksanen, T

AU - Pörsti, I

AU - Salminen, E

AU - Siitonen, S

AU - Stuckey, H

AU - Toppila, A

AU - Vapaatalo, H

PY - 1990

Y1 - 1990

N2 - A placebo-controlled double-blind study was conducted on the efficacy of Lactobacillus GG in preventing travellers' diarrhoea. Altogether 820 persons travelling on holiday to southern Turkey to two destinations were randomized into two groups receiving either Lactobacillus GG or placebo in identical sachets. On the return flight each participant completed a questionnaire indicating the incidence of diarrhoea and related symptoms during the trip. Of the original group 756 (92%) subjects completed the study acceptably. The overall incidence of diarrhoea was 43.8% (331 cases). The total incidence of diarrhoea in the placebo group was 46.5% and in the Lactobacillus GG 41.0% indicating an overall protection of 11.8%. Protection rates varied between two different destinations with the maximum protection rate reported as 39.5%. Among older age groups there was significantly less diarrhoea when compared to younger travellers. Lactobacillus GG appeared to be effective in reducing the occurrence of travellers' diarrhoea in one of the two destinations with no side effects.

AB - A placebo-controlled double-blind study was conducted on the efficacy of Lactobacillus GG in preventing travellers' diarrhoea. Altogether 820 persons travelling on holiday to southern Turkey to two destinations were randomized into two groups receiving either Lactobacillus GG or placebo in identical sachets. On the return flight each participant completed a questionnaire indicating the incidence of diarrhoea and related symptoms during the trip. Of the original group 756 (92%) subjects completed the study acceptably. The overall incidence of diarrhoea was 43.8% (331 cases). The total incidence of diarrhoea in the placebo group was 46.5% and in the Lactobacillus GG 41.0% indicating an overall protection of 11.8%. Protection rates varied between two different destinations with the maximum protection rate reported as 39.5%. Among older age groups there was significantly less diarrhoea when compared to younger travellers. Lactobacillus GG appeared to be effective in reducing the occurrence of travellers' diarrhoea in one of the two destinations with no side effects.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Diarrhea/prevention & control

KW - Double-Blind Method

KW - Female

KW - Humans

KW - Lactobacillus/physiology

KW - Male

KW - Middle Aged

KW - Randomized Controlled Trials as Topic

KW - Surveys and Questionnaires

KW - Travel

KW - Turkey

U2 - 10.3109/07853899009147242

DO - 10.3109/07853899009147242

M3 - Article

C2 - 2184847

SN - 0785-3890

VL - 22

SP - 53

EP - 56

JO - Annals of Medicine

JF - Annals of Medicine

IS - 1

ER -

Prevention of Travellers Diarrhoea by Lactobacillus GG

Abstract

Keywords

UN SDGs

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