Abstract
The Prospective Lynch Syndrome Database (PLSD) has been developed as an international, multicentre, prospective, observational study that aims to provide age and organ-specific cancer risks according to gene and gender, estimates of survival after cancer and information on the effects of interventions. Recent reports from PLSD provided improved estimates of cancer risks and survival and showed that different time intervals between surveillance colonoscopies did not affect the incidence, stage or prognosis of colorectal cancer. The PLSD reports suggest that current management guidelines for Lynch syndrome should be revised in light of the different gene and gender-specific cancer risks and the good prognosis for the most commonly associated cancers. In this review, we describe the discrepancies between the current management guidelines for Lynch Syndrome and the most recent prospective observational studies, indicating the areas of further research.
Original language | English |
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Pages (from-to) | 35-39 |
Number of pages | 5 |
Journal | FAMILIAL CANCER |
Volume | 20 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2021 |
Externally published | Yes |
Publication type | A2 Review article in a scientific journal |
Funding
Open access funding provided by University of Helsinki including Helsinki University Central Hospital. TTS was supported by the Emil Aaltonen Foundation, the Finnish Medical Foundation and the Sigrid Juselius Foundation. TTS is a co-owner of Healthfund Finland Oy. Open access funding provided by University of Helsinki including Helsinki University Central Hospital. TTS was supported by the Emil Aaltonen Foundation, the Finnish Medical Foundation and the Sigrid Juselius Foundation. TTS is a co-owner of Healthfund Finland Oy.
Keywords
- Cancer incidence
- Colonoscopy
- Colorectal cancer
- Hereditary non-polyposis colorectal cancer
- Lynch syndrome
- PLSD
- Precision medicine
- Prevention
- Surveillance
ASJC Scopus subject areas
- Genetics
- Oncology
- Genetics(clinical)
- Cancer Research