Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valerie Turcot; Yingchang Lu; Heather M. Highland; Claudia Schurmann; Anne E. Justice; Rebecca S. Fine; Jonathan P. Bradfield; Tonu Esko; Ayush Giri; H Puolijoki; Mariaelisa Graff; Xiuqing Guo; Audrey E. Hendricks; Tugce Karaderi; Adelheid Lempradl; Adam E. Locke; Anubha Mahajan; Eirini Marouli; Suthesh Sivapalaratnam; Kristin L. Young; Tamuno Alf; Mary F. Feitosa; Nicholas G. D. Masca; Alisa K. Manning; Carolina Medina-Gomez; Poorva Mudgal; Maggie C. Y. Ng; Alex P. Reiner; Sailaja Vedantam; Sara M. Willems; Thomas W. Winkler; Goncalo Abecasis; Katja K. Aben; Dewan Alam; Jussi Hernesniemi; Mika Kähönen; Terho Lehtimäki; Leo-Pekka Lyytikäinen; Kjell Nikus

doi:10.1038/s41588-017-0011-x

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valerie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tonu Esko, Ayush Giri, H Puolijoki, Mariaelisa Graff, Xiuqing Guo, Audrey E. Hendricks, Tugce Karaderi, Adelheid Lempradl, Adam E. Locke, Anubha Mahajan, Eirini Marouli, Suthesh Sivapalaratnam, Kristin L. YoungTamuno Alf, Mary F. Feitosa, Nicholas G. D. Masca, Alisa K. Manning, Carolina Medina-Gomez, Poorva Mudgal, Maggie C. Y. Ng, Alex P. Reiner, Sailaja Vedantam, Sara M. Willems, Thomas W. Winkler, Goncalo Abecasis, Katja K. Aben, Dewan Alam, Jussi Hernesniemi, Mika Kähönen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Kjell Nikus

Research output: Contribution to journal › Article › Scientific › peer-review

128 Citations (Scopus)

Original language	English
Pages (from-to)	26-41
Journal	Nature Genetics
Volume	50
Issue number	1
DOIs	https://doi.org/10.1038/s41588-017-0011-x
Publication status	Published - 2018
Publication type	A1 Journal article-refereed

Keywords

Genome-wide association studies,Obesity

Publication forum classification

Publication forum level 3

Access to Document

10.1038/s41588-017-0011-x

Cite this

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Puolijoki, H., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., ... Nikus, K. (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics, 50(1), 26-41. https://doi.org/10.1038/s41588-017-0011-x

Turcot, Valerie ; Lu, Yingchang ; Highland, Heather M. ; Schurmann, Claudia ; Justice, Anne E. ; Fine, Rebecca S. ; Bradfield, Jonathan P. ; Esko, Tonu ; Giri, Ayush ; Puolijoki, H ; Graff, Mariaelisa ; Guo, Xiuqing ; Hendricks, Audrey E. ; Karaderi, Tugce ; Lempradl, Adelheid ; Locke, Adam E. ; Mahajan, Anubha ; Marouli, Eirini ; Sivapalaratnam, Suthesh ; Young, Kristin L. ; Alf, Tamuno ; Feitosa, Mary F. ; Masca, Nicholas G. D. ; Manning, Alisa K. ; Medina-Gomez, Carolina ; Mudgal, Poorva ; Ng, Maggie C. Y. ; Reiner, Alex P. ; Vedantam, Sailaja ; Willems, Sara M. ; Winkler, Thomas W. ; Abecasis, Goncalo ; Aben, Katja K. ; Alam, Dewan ; Hernesniemi, Jussi ; Kähönen, Mika ; Lehtimäki, Terho ; Lyytikäinen, Leo-Pekka ; Nikus, Kjell. / Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. In: Nature Genetics. 2018 ; Vol. 50, No. 1. pp. 26-41.

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keywords = "Genome-wide association studies,Obesity, Genome-wide association studies,Obesity",

author = "Valerie Turcot and Yingchang Lu and Highland, {Heather M.} and Claudia Schurmann and Justice, {Anne E.} and Fine, {Rebecca S.} and Bradfield, {Jonathan P.} and Tonu Esko and Ayush Giri and H Puolijoki and Mariaelisa Graff and Xiuqing Guo and Hendricks, {Audrey E.} and Tugce Karaderi and Adelheid Lempradl and Locke, {Adam E.} and Anubha Mahajan and Eirini Marouli and Suthesh Sivapalaratnam and Young, {Kristin L.} and Tamuno Alf and Feitosa, {Mary F.} and Masca, {Nicholas G. D.} and Manning, {Alisa K.} and Carolina Medina-Gomez and Poorva Mudgal and Ng, {Maggie C. Y.} and Reiner, {Alex P.} and Sailaja Vedantam and Willems, {Sara M.} and Winkler, {Thomas W.} and Goncalo Abecasis and Aben, {Katja K.} and Dewan Alam and Jussi Hernesniemi and Mika K{\"a}h{\"o}nen and Terho Lehtim{\"a}ki and Leo-Pekka Lyytik{\"a}inen and Kjell Nikus",

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doi = "10.1038/s41588-017-0011-x",

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Turcot, V, Lu, Y, Highland, HM, Schurmann, C, Justice, AE, Fine, RS, Bradfield, JP, Esko, T, Giri, A, Puolijoki, H, Graff, M, Guo, X, Hendricks, AE, Karaderi, T, Lempradl, A, Locke, AE, Mahajan, A, Marouli, E, Sivapalaratnam, S, Young, KL, Alf, T, Feitosa, MF, Masca, NGD, Manning, AK, Medina-Gomez, C, Mudgal, P, Ng, MCY, Reiner, AP, Vedantam, S, Willems, SM, Winkler, TW, Abecasis, G, Aben, KK, Alam, D, Hernesniemi, J , Kähönen, M , Lehtimäki, T , Lyytikäinen, L-P & Nikus, K 2018, 'Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity', Nature Genetics, vol. 50, no. 1, pp. 26-41. https://doi.org/10.1038/s41588-017-0011-x

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. / Turcot, Valerie; Lu, Yingchang; Highland, Heather M.; Schurmann, Claudia; Justice, Anne E.; Fine, Rebecca S.; Bradfield, Jonathan P.; Esko, Tonu; Giri, Ayush; Puolijoki, H; Graff, Mariaelisa; Guo, Xiuqing; Hendricks, Audrey E.; Karaderi, Tugce; Lempradl, Adelheid; Locke, Adam E.; Mahajan, Anubha; Marouli, Eirini; Sivapalaratnam, Suthesh; Young, Kristin L.; Alf, Tamuno; Feitosa, Mary F.; Masca, Nicholas G. D.; Manning, Alisa K.; Medina-Gomez, Carolina; Mudgal, Poorva; Ng, Maggie C. Y.; Reiner, Alex P.; Vedantam, Sailaja; Willems, Sara M.; Winkler, Thomas W.; Abecasis, Goncalo; Aben, Katja K.; Alam, Dewan; Hernesniemi, Jussi ; Kähönen, Mika ; Lehtimäki, Terho ; Lyytikäinen, Leo-Pekka ; Nikus, Kjell.

In: Nature Genetics, Vol. 50, No. 1, 2018, p. 26-41.

Research output: Contribution to journal › Article › Scientific › peer-review

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T1 - Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

AU - Turcot, Valerie

AU - Lu, Yingchang

AU - Highland, Heather M.

AU - Schurmann, Claudia

AU - Justice, Anne E.

AU - Fine, Rebecca S.

AU - Bradfield, Jonathan P.

AU - Esko, Tonu

AU - Giri, Ayush

AU - Puolijoki, H

AU - Graff, Mariaelisa

AU - Guo, Xiuqing

AU - Hendricks, Audrey E.

AU - Karaderi, Tugce

AU - Lempradl, Adelheid

AU - Locke, Adam E.

AU - Mahajan, Anubha

AU - Marouli, Eirini

AU - Sivapalaratnam, Suthesh

AU - Young, Kristin L.

AU - Alf, Tamuno

AU - Feitosa, Mary F.

AU - Masca, Nicholas G. D.

AU - Manning, Alisa K.

AU - Medina-Gomez, Carolina

AU - Mudgal, Poorva

AU - Ng, Maggie C. Y.

AU - Reiner, Alex P.

AU - Vedantam, Sailaja

AU - Willems, Sara M.

AU - Winkler, Thomas W.

AU - Abecasis, Goncalo

AU - Aben, Katja K.

AU - Alam, Dewan

AU - Hernesniemi, Jussi

AU - Kähönen, Mika

AU - Lehtimäki, Terho

AU - Lyytikäinen, Leo-Pekka

AU - Nikus, Kjell

PY - 2018

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DO - 10.1038/s41588-017-0011-x

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SP - 26

EP - 41

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

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