Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks

Niels Hadrup; Anne T. Saber; Zdenka O. Kyjovska; Nicklas R. Jacobsen; Minnamari Vippola; Essi Sarlin; Yaobo Ding; Otmar Schmid; Håkan Wallin; Keld A. Jensen; Ulla Vogel

doi:10.1016/j.etap.2019.103303

Pulmonary toxicity of Fe₂O₃, ZnFe₂O₄, NiFe₂O₄ and NiZnFe₄O₈ nanomaterials: Inflammation and DNA strand breaks

Niels Hadrup, Anne T. Saber, Zdenka O. Kyjovska, Nicklas R. Jacobsen, Minnamari Vippola, Essi Sarlin, Yaobo Ding, Otmar Schmid, Håkan Wallin, Keld A. Jensen, Ulla Vogel

Materials Science and Environmental Engineering

Research output: Contribution to journal › Article › Scientific › peer-review

47 Citations (Scopus)

24 Downloads (Pure)

Abstract

Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe₂O₃ nanoparticles and nanorods; and three MFe₂O₄ spinels: NiZnFe₄O₈, ZnFe₂O₄, and NiFe₂O₄ nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe₂O₃ rods (1 day), ZnFe₂O₄ (1, 3 days), NiFe₂O₄ (1, 3, 28 days), Fe₂O₃ (28 days) and NiZnFe₄O₈ (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe₂O₃ particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe₃O₄), the first study of the pulmonary toxicity of MFe₂O₄ spinel nanomaterials.

Original language	English
Article number	103303
Number of pages	11
Journal	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume	74
Early online date	2019
DOIs	https://doi.org/10.1016/j.etap.2019.103303
Publication status	Published - Feb 2020
Publication type	A1 Journal article-refereed

Keywords

Iron
Metal oxides
Nanomaterial
Nickel
Pulmonary
Zinc

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Toxicology
Pharmacology
Health, Toxicology and Mutagenesis

Access to Document

10.1016/j.etap.2019.103303

1-s2.0-S1382668919301784-mainFinal published version, 4.22 MBLicence: CC BY-NC-ND

http://urn.fi/URN:NBN:fi:tuni-202001131204Licence: CC BY-NC-ND

Cite this

Hadrup, N., Saber, A. T., Kyjovska, Z. O., Jacobsen, N. R., Vippola, M., Sarlin, E., Ding, Y., Schmid, O., Wallin, H., Jensen, K. A., & Vogel, U. (2020). Pulmonary toxicity of Fe₂O₃, ZnFe₂O₄, NiFe₂O₄ and NiZnFe₄O₈ nanomaterials: Inflammation and DNA strand breaks. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 74, Article 103303. https://doi.org/10.1016/j.etap.2019.103303

@article{9046eb293b9e41279940cd84fecb8a22,

title = "Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials: Inflammation and DNA strand breaks",

abstract = "Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.",

keywords = "Iron, Metal oxides, Nanomaterial, Nickel, Pulmonary, Zinc",

author = "Niels Hadrup and Saber, {Anne T.} and Kyjovska, {Zdenka O.} and Jacobsen, {Nicklas R.} and Minnamari Vippola and Essi Sarlin and Yaobo Ding and Otmar Schmid and H{\aa}kan Wallin and Jensen, {Keld A.} and Ulla Vogel",

year = "2020",

month = feb,

doi = "10.1016/j.etap.2019.103303",

language = "English",

volume = "74",

journal = "ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY",

issn = "1382-6689",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Pulmonary toxicity of Fe2O3, ZnFe2O4, NiFe2O4 and NiZnFe4O8 nanomaterials

T2 - Inflammation and DNA strand breaks

AU - Hadrup, Niels

AU - Saber, Anne T.

AU - Kyjovska, Zdenka O.

AU - Jacobsen, Nicklas R.

AU - Vippola, Minnamari

AU - Sarlin, Essi

AU - Ding, Yaobo

AU - Schmid, Otmar

AU - Wallin, Håkan

AU - Jensen, Keld A.

AU - Vogel, Ulla

PY - 2020/2

Y1 - 2020/2

N2 - Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.

AB - Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: Fe2O3 nanoparticles and nanorods; and three MFe2O4 spinels: NiZnFe4O8, ZnFe2O4, and NiFe2O4 nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation – neutrophil influx into bronchoalveolar lavage (BAL) fluid – occurred for Fe2O3 rods (1 day), ZnFe2O4 (1, 3 days), NiFe2O4 (1, 3, 28 days), Fe2O3 (28 days) and NiZnFe4O8 (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both Fe2O3 particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (Fe3O4), the first study of the pulmonary toxicity of MFe2O4 spinel nanomaterials.

KW - Iron

KW - Metal oxides

KW - Nanomaterial

KW - Nickel

KW - Pulmonary

KW - Zinc

U2 - 10.1016/j.etap.2019.103303

DO - 10.1016/j.etap.2019.103303

M3 - Article

AN - SCOPUS:85076229991

SN - 1382-6689

VL - 74

JO - ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

JF - ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

M1 - 103303

ER -