Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound

Craig S. Carlson; Nicole Anderton; Antje Pohl; Andrew J. Smith; Nobuki Kudo; Michiel Postema

doi:10.35848/1347-4065/ac467f

Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound

Craig S. Carlson, Nicole Anderton, Antje Pohl, Andrew J. Smith, Nobuki Kudo, Michiel Postema

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Controlled tablet disintegration is useful for chemical consistency checks. This study monitored the swelling of 54 analgesia tablets from two different batches, during 13-6-MHz brightness-mode sonication and simultaneous video recording. The tablets were placed on an acoustic reflector inside a container and sonicated from the top. Sonication shortened the displacement half-life by 17%-27%. During tablet swelling, their speed of sound increased linearly, confirming the linearity of this process. Diagnostic ultrasound significantly decreased tablet disintegration times, supporting the ultrasound-microbubble interaction hypothesis.

Original language	English
Article number	SG1030
Journal	Japanese Journal of Applied Physics
Volume	61
Issue number	SG
DOIs	https://doi.org/10.35848/1347-4065/ac467f
Publication status	Published - 2022
Publication type	A1 Journal article-refereed

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Carlson_et_al_2021_Jpn._J._Appl._Phys._10.35848_1347_4065_ac467fAccepted author manuscript, 3.37 MBLicence: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-202204253496Licence: CC BY-NC-ND

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title = "Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound",

abstract = "Controlled tablet disintegration is useful for chemical consistency checks. This study monitored the swelling of 54 analgesia tablets from two different batches, during 13-6-MHz brightness-mode sonication and simultaneous video recording. The tablets were placed on an acoustic reflector inside a container and sonicated from the top. Sonication shortened the displacement half-life by 17%-27%. During tablet swelling, their speed of sound increased linearly, confirming the linearity of this process. Diagnostic ultrasound significantly decreased tablet disintegration times, supporting the ultrasound-microbubble interaction hypothesis.",

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AU - Kudo, Nobuki

AU - Postema, Michiel

PY - 2022

Y1 - 2022

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AB - Controlled tablet disintegration is useful for chemical consistency checks. This study monitored the swelling of 54 analgesia tablets from two different batches, during 13-6-MHz brightness-mode sonication and simultaneous video recording. The tablets were placed on an acoustic reflector inside a container and sonicated from the top. Sonication shortened the displacement half-life by 17%-27%. During tablet swelling, their speed of sound increased linearly, confirming the linearity of this process. Diagnostic ultrasound significantly decreased tablet disintegration times, supporting the ultrasound-microbubble interaction hypothesis.

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Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound

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